Lattice QCD calculation of ππ\pi\pi scattering length

We study s-wave pion-pion ($\pi\pi$) scattering length in lattice QCD for pion masses ranging from 330 MeV to 466 MeV. In the "Asqtad" improved staggered fermion formulation, we calculate the $\pi\pi$ four-point functions for isospin I=0 and 2 channels, and use chiral perturbation theory at next-to-leading order to extrapolate our simulation results. Extrapolating to the physical pion mass gives the scattering lengths as $m_\pi a_0^{I=2} = -0.0416(2)$ and $m_\pi a_0^{I=0} = 0.186(2)$ for isospin I=2 and 0 channels, respectively. Our lattice simulation for $\pi\pi$ scattering length in the I=0 channel is an exploratory study, where we include the disconnected contribution, and our preliminary result is near to its experimental value. These simulations are performed with MILC 2+1 flavor gauge configurations at lattice spacing $a \approx 0.15$ fm.Comment: Remove some typo

Multi-aspect, robust, and memory exclusive guest os fingerprinting

Precise fingerprinting of an operating system (OS) is critical to many security and forensics applications in the cloud, such as virtual machine (VM) introspection, penetration testing, guest OS administration, kernel dump analysis, and memory forensics. The existing OS fingerprinting techniques primarily inspect network packets or CPU states, and they all fall short in precision and usability. As the physical memory of a VM always exists in all these applications, in this article, we present OS-Sommelier+, a multi-aspect, memory exclusive approach for precise and robust guest OS fingerprinting in the cloud. It works as follows: given a physical memory dump of a guest OS, OS-Sommelier+ first uses a code hash based approach from kernel code aspect to determine the guest OS version. If code hash approach fails, OS-Sommelier+ then uses a kernel data signature based approach from kernel data aspect to determine the version. We have implemented a prototype system, and tested it with a number of Linux kernels. Our evaluation results show that the code hash approach is faster but can only fingerprint the known kernels, and data signature approach complements the code signature approach and can fingerprint even unknown kernels

Experimental and computational investigation of confined laser-induced breakdown spectroscopy

This paper presents an experimental and computational study on laser-induced breakdown spectroscopy (LIBS) for both unconfined flat surface and confined cavity cases. An integrated LIBS system is employed to acquire the shockwave and plasma plume images. The computational model consists of the mass, momentum, and energy conservation equations, which are necessary to describe shockwave behaviors. The numerical predictions are validated against shadowgraphic images in terms of shockwave expansion and reflection. The three-dimensional (3D) shockwave morphology and velocity fields are displayed and discussed

Beyond relativistic mean-field studies of low-lying states in neutron-deficient krypton isotopes

Neutron-deficient krypton isotopes are of particular interest due to the coexistence of oblate and prolate shapes in low-lying states and the transition of ground-state from one dominate shape to another as a function of neutron number. A detailed interpretation of these phenomena in neutron-deficient Kr isotopes requires the use of a method going beyond a mean-field approach that permits to determine spectra and transition probabilities. The aim of this work is to provide a systematic calculation of low-lying state in the even-even 68-86Kr isotopes and to understand the shape coexistence phenomenon and the onset of large collectivity around N=40 from beyond relativistic mean-field studies. The starting point of our method is a set of relativistic mean-field+BCS wave functions generated with a constraint on triaxial deformations (beta, gamma). The excitation energies and electric multipole transition strengths of low-lying states are calculated by solving a five-dimensional collective Hamiltonian (5DCH) with parameters determined by the mean-field wave functions. To examine the role of triaxiality, a configuration mixing of both particle number (PN) and angular momentum (AM) projected axially deformed states is also carried out within the exact generator coordinate method (GCM) based on the same energy density functional. The energy surfaces, the excitation energies of 0^+_2, 2^+_1, 2^+_2 states, as well as the E0 and E2 transition strengths are compared with the results of similar 5DCH calculations but with parameters determined by the non-relativistic mean-field wave functions, as well as with the available data...Comment: 23 pages, 10 figure

ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells.

BACKGROUND: Many viruses depend on the extensive membranous network of the endoplasmic reticulum (ER) for their translation, replication, and packaging. Certain membrane modifications of the ER can be a trigger for ER stress, as well as the accumulation of viral protein in the ER by viral infection. Then, unfolded protein response (UPR) is activated to alleviate the stress. Zika virus (ZIKV) is a mosquito-borne flavivirus and its infection causes microcephaly in newborns and serious neurological complications in adults. Here, we investigated ER stress and the regulating model of UPR in ZIKV-infected neural cells in vitro and in vivo. METHODS: Mice deficient in type I and II IFN receptors were infected with ZIKV via intraperitoneal injection and the nervous tissues of the mice were assayed at 5 days post-infection. The expression of phospho-IRE1, XBP1, and ATF6 which were the key markers of ER stress were analyzed by immunohistochemistry assay in vivo. Additionally, the nuclear localization of XBP1s and ATF6n were analyzed by immunohistofluorescence. Furthermore, two representative neural cells, neuroblastoma cell line (SK-N-SH) and astrocytoma cell line (CCF-STTG1), were selected to verify the ER stress in vitro. The expression of BIP, phospho-elF2α, phospho-IRE1, and ATF6 were analyzed through western blot and the nuclear localization of XBP1s was performed by confocal immunofluorescence microscopy. RT-qPCR was also used to quantify the mRNA level of the UPR downstream genes in vitro and in vivo. RESULTS: ZIKV infection significantly upregulated the expression of ER stress markers in vitro and in vivo. Phospho-IRE1 and XBP1 expression significantly increased in the cerebellum and mesocephalon, while ATF6 expression significantly increased in the mesocephalon. ATF6n and XBP1s were translocated into the cell nucleus. The levels of BIP, ATF6, phospho-elf2α, and spliced xbp1 also significantly increased in vitro. Furthermore, the downstream genes of UPR were detected to investigate the regulating model of the UPR during ZIKV infection in vitro and in vivo. The transcriptional levels of atf4, gadd34, chop, and edem-1 in vivo and that of gadd34 and chop in vitro significantly increased. CONCLUSION: Findings in this study demonstrated that ZIKV infection activates ER stress in neural cells. The results offer clues to further study the mechanism of neuropathogenesis caused by ZIKV infection

Small angle neutron scattering contrast variation reveals heterogeneities of interactions in protein gels

The structure of model gluten protein gels prepared in ethanol/water is investigated by small angle X-ray (SAXS) and neutrons (SANS) scattering. We show that gluten gels display radically different SAXS and SANS profiles when the solvent is (at least partially) deuterated. The detailed analysis of the SANS signal as a function of the solvent deuteration demonstrates heterogeneities of sample deuteration at different length scales. The progressive exchange between the protons (H) of the proteins and the deuteriums (D) of the solvent is inhomogeneous and 60 nm large zones that are enriched in H are evidenced. In addition, at low protein concentration, in the sol state, solvent deuteration induces a liquid/liquid phase separation. Complementary biochemical and structure analyses show that the denser protein phase is more protonated and specifically enriched in glutenin, the polymeric fraction of gluten proteins. These findings suggest that the presence of H-rich zones in gluten gels would arise from the preferential interaction of glutenin polymers through a tight network of non-exchangeable intermolecular hydrogen bonds.Comment: Soft Matter, Royal Society of Chemistry, 201

Core-Selecting Auctions for Dynamically Allocating Heterogeneous VMs in Cloud Computing

In a cloud market, the cloud provider provisions heterogeneous virtual machine (VM) instances from its resource pool, for allocation to cloud users. Auction-based allocations are efficient in assigning VMs to users who value them the most. Existing auction design often overlooks the heterogeneity of VMs, and does not consider dynamic, demand-driven VM provisioning. Moreover, the classic VCG auction leads to unsatisfactory seller revenues and vulnerability to a strategic bidding behavior known as shill bidding. This work presents a new type of core-selecting VM auctions, which are combinatorial auctions that always select bidder charges from the core of the price vector space, with guaranteed economic efficiency under truthful bidding. These auctions represent a comprehensive three-phase mechanism that instructs the cloud provider to judiciously assemble, allocate, and price VM bundles. They are proof against shills, can improve seller revenue over existing auction mechanisms, and can be tailored to maximize truthfulness.published_or_final_versio