Strange stars with different quark mass scalings

We investigate the stability of strange quark matter and the properties of the corresponding strange stars, within a wide range of quark mass scaling. The calculation shows that the resulting maximum mass always lies between 1.5 solor mass and 1.8 solor mass for all the scalings chosen here. Strange star sequences with a linear scaling would support less gravitational mass, and a change (increase or decrease) of the scaling around the linear scaling would lead to a larger maximum mass. Radii invariably decrease with the mass scaling. Then the larger the scaling, the faster the star might spin. In addition, the variation of the scaling would cause an order of magnitude change of the strong electric field on quark surface, which is essential to support possible crusts of strange stars against gravity and may then have some astrophysical implications.Comment: 5 pages, 6 figures, 1 table. accepted by M

hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation

Sef (similar expression to fgf genes) was identified as an effective antagonist of fibroblast growth factor (FGF) in vertebrates. Previous reports have demonstrated that Sef interacts with FGF receptors (FGFRs) and inhibits FGF signaling, however, its role in regulating epidermal growth factor receptor (EGFR) signaling remains unclear. In this report, we found that hSef localizes to the plasma membrane (PM) and is subjected to rapid internalization and well localizes in early/recycling endosomes while poorly in late endosomes/lysosomes. We observed that hSef interacts and functionally colocalizes with EGFR in early endosomes in response to EGF stimulation. Importantly, we demonstrated that overexpression of hSef attenuates EGFR degradation and potentiates EGF-mediated mitogen-activated protein kinase (MAPK) signaling by interfering EGFR trafficking. Finally, our data showed that, with overexpression of hSef, elevated levels of Erk phosphorylation and differentiation of rat pheochromocytoma (PC12) cells occur in response to EGF stimulation. Taken together, these data suggest that hSef plays a positive role in the EGFR-mediated MAPK signaling pathway. This report, for the first time, reveals opposite roles for Sef in EGF and FGF signalings

Bridgeness: A Local Index on Edge Significance in Maintaining Global Connectivity

Edges in a network can be divided into two kinds according to their different roles: some enhance the locality like the ones inside a cluster while others contribute to the global connectivity like the ones connecting two clusters. A recent study by Onnela et al uncovered the weak ties effects in mobile communication. In this article, we provide complementary results on document networks, that is, the edges connecting less similar nodes in content are more significant in maintaining the global connectivity. We propose an index named bridgeness to quantify the edge significance in maintaining connectivity, which only depends on local information of network topology. We compare the bridgeness with content similarity and some other structural indices according to an edge percolation process. Experimental results on document networks show that the bridgeness outperforms content similarity in characterizing the edge significance. Furthermore, extensive numerical results on disparate networks indicate that the bridgeness is also better than some well-known indices on edge significance, including the Jaccard coefficient, degree product and betweenness centrality.Comment: 10 pages, 4 figures, 1 tabl

A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries)

201

Exploring f(T)f(T) Gravity via strongly lensed fast radio bursts

This study aims to investigate the strong gravitational lensing effects in $f(T)$ gravity. We present the theoretical analytic expressions for the lensing effects in $f(T)$ gravity, including deflection angle, magnification, and time delay. On this basis, we also take the plasma lensing effect into consideration. We compare the lensing effects between the General Relativity in a vacuum environment and the $f(T)$ gravity in a plasma environment. From a strongly lensed fast radio burst, the results indicate that in a plasma environment, General Relativity and $f(T)$ gravity can generate indistinguishable image positions, but the magnification and time delay on these positions are significantly different, which can be distinguished by current facilities in principle. Therefore, the discrepancies between observational results and theoretical expectations can serve as clues for a modified gravity theory and provide constraints on $f(T)$ gravity