Prescribing patterns of low doses of antipsychotic medications in older Asian patients with schizophrenia, 2001-2009

Background: This study examined the use of low doses of antipsychotic medications (300mg/day CPZeq or less) in older Asian patients with schizophrenia and its demographic and clinical correlates. Methods: Information on hospitalized patients with schizophrenia, aged 55 years or older, was extracted from the database of the Research on Asian Psychotropic Prescription Patterns (REAP) study (2001-2009). Data on 1,452 patients in eight Asian countries and territories including China, Hong Kong, Japan, Korea, Singapore, Taiwan, India, and Malaysia were analyzed. Sociodemographic and clinical characteristics and antipsychotic prescriptions were recorded using a standardized protocol and data collection procedure. Results: The prescription frequency for low doses of antipsychotic medications was 40.9% in the pooled sample. Multiple logistic regression analysis of the whole sample showed that patients on low doses of antipsychotic medications were more likely to be female, have an older age, a shorter length of illness, and less positive symptoms. Of patients in the six countries and territories that participated in all the surveys between 2001 and 2009, those in Japan were less likely to receive low doses of antipsychotics. Conclusion: Low doses of antipsychotic medications were only applied in less than half of older Asian patients with schizophreni

The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion.

Aminopeptidase N (CD13) is a widely expressed cell surface metallopeptidase involved in the migration of cancer and endothelial cells. Apart from our demonstration that CD13 modulates the efficacy of tumor necrosis factor-α-induced apoptosis in neutrophils, no other function for CD13 has been ascribed in this cell. We hypothesized that CD13 may be involved in neutrophil migration and/or homotypic aggregation. Using purified human blood neutrophils we confirmed the expression of CD13 on neutrophils and its up-regulation by pro-inflammatory agonists. However, using the anti-CD13 monoclonal antibody WM-15 and the aminopeptidase enzymatic inhibitor bestatin we were unable to demonstrate any direct involvement of CD13 in neutrophil polarisation or chemotaxis. In contrast, IL-8-mediated neutrophil migration in type I collagen gels was significantly impaired by the anti-CD13 monoclonal antibodies WM-15 and MY7. Notably, these antibodies also induced significant homotypic aggregation of neutrophils, which was dependent on CD13 cross-linking and was attenuated by phosphoinositide 3-kinase and extracellular signal-related kinase 1/2 inhibition. Live imaging demonstrated that in WM-15-treated neutrophils, where homotypic aggregation was evident, the number of cells entering IL-8 impregnated collagen I gels was significantly reduced. These data reveal a novel role for CD13 in inducing homotypic aggregation in neutrophils, which results in a transmigration deficiency; this mechanism may be relevant to neutrophil micro-aggregation in vivo.This work was funded by a Medical Research Council Research Training Fellowship to CAF (G0900329), Addenbrooke’s Charitable Trust (ACT), CUHNHSFT, Papworth Hospital NHS Foundation Trust and the NIHR Cambridge Biomedical Research Centre. CAF received a Raymond and Beverly Sackler Studentship.This is the final version of the article. It first appeared from the Public Library of Science via http://dx.doi.org/10.1371/journal.pone.016010

The Economics of Direct Flights

Many tourist industry officials often lobby their local governments to invest heavily airport infrastructure (e.g. longer runways and larger terminals) in order to accommodate direct flights. We evaluate the impact of the recent initiation of direct flights from the U.S. west coast to Hawaii's neighbor islands, bypassing the previous hub, Honolulu, using interrupted time series analysis. We find a significant, though modest, increase in neighbor island travel. Direct flights may not always generate enough additional travel demand to warrant those investments.

Discrimination in Consumer Credit Markets

Using household data from the 1983 Survey of Consumer Finances, the hypothesis that there is no discrimination against protected groups in the provision of credit is tested. Using household data avoids the inherent sample selectivity problem of other research based on analyses of applicant data. The authors find that, after controlling for other factors, nonwhites are more likely to be rejected for credit than whites. Also, nonwhites, single parent families, and female heads are more likely to be discouraged from applying for credit. Taken together these results suggest that race is still a factor in the allocation of consumer credit.Consumer Credit; Credit; Discrimination; Finance

Adjunctive benzodiazepine treatment of hospitalized schizophrenia patients in Asia from 2001 to 2008

10.1017/S146114571000163XThe International Journal of Neuropsychopharmacology146735-74

Colors of a Second Earth II: Effects of Clouds on Photometric Characterization of Earth-like Exoplanets

As a test-bed for future investigations of directly imaged terrestrial exoplanets, we present the recovery of the surface components of the Earth from multi-band diurnal light curves obtained with the EPOXI spacecraft. We find that the presence and longitudinal distribution of ocean, soil and vegetation are reasonably well reproduced by fitting the observed color variations with a simplified model composed of a priori known albedo spectra of ocean, soil, vegetation, snow and clouds. The effect of atmosphere, including clouds, on light scattered from surface components is modeled using a radiative transfer code. The required noise levels for future observations of exoplanets are also determined. Our model-dependent approach allows us to infer the presence of major elements of the planet (in the case of the Earth, clouds and ocean) with observations having S/N $\gtrsim 10$ in most cases and with high confidence if S/N $\gtrsim 20$. In addition, S/N $\gtrsim 100$ enables us to detect the presence of components other than ocean and clouds in a fairly model-independent way. Degradation of our inversion procedure produced by cloud cover is also quantified. While cloud cover significantly dilutes the magnitude of color variations compared to the cloudless case, the pattern of color changes remains. Therefore, the possibility of investigating surface features through light curve fitting remains even for exoplanets with cloud cover similar to the Earth's.Comment: 33 pages, 16 figures, accepted for publication in ApJ (discussion, references, and description of data reduction added, typo fixed