geometrical vision measurement in mechanical engineering

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Integrative analysis of genomic sequencing data reveals higher prevalence of LRP1B mutations in lung adenocarcinoma patients with COPD

AbstractBoth chronic Obstruction Pulmonary Disease (COPD) and lung cancer are leading causes of death globally. Although COPD and lung cancer coexist frequently, it is unknown whether lung cancer patients with COPD harbor distinct genomic characteristics compared to those without COPD. In this study, we retrospectively analyzed genomic sequencing data from 272 patients with lung adenocarcinoma (LUAD) and compared the genetic alterations in LUAD patients with and without COPD. Integrative analysis of whole-genome and exome sequencing data revealed that COPD and non-COPD groups showed high concordance in mutational burden and spectra. Notably, we also found that EGFR mutations were more prevalent in LUAD patients without COPD, whereas mutated LRP1B was more frequently observed in LUAD patients with COPD. In addition, multi-variable analysis with logistic regression demonstrated that mutation of LRP1B was a predictive marker for the presence of COPD in the patients with LUAD. Our analysis demonstrated for the first time the high concordance in genomic alterations between the tumors from LUAD patients with and without COPD. We also identified higher prevalence of LRP1B among the LUAD patients with COPD, which might help understand the underlying mechanisms which link COPD and lung cancer.</jats:p

Observation of Universal Expansion Anisotropy from Cold Atoms to Hot Quark-Gluon Plasma

Azimuthal anisotropy has been ubiquitously observed in high-energy proton-proton, proton-nucleus, and nucleus-nucleus (heavy-ion) collisions, shaking the early belief that those anisotropies must stem from utterly strong interactions. This work reports a study of anisotropic expansion of cold $^{6}$Li Fermi gases, initially trapped in an anisotropic potential, as a function of the interaction strength that can be readily tuned by an external magnetic field. It is found that the expansion anisotropy builds up quickly at small interaction strength, without the need of utterly strong interactions. A universal behavior of the expansion anisotropy is quantitatively observed between cold-atom and heavy-ion systems, despite their vast differences in physics. This universality will potentially unify a variety of disciplines in nature, from the weakly interacting dilute systems of gases to the strongly interacting quark-gluon plasma of the early universe.Comment: 11 pages, 11 figure

Dual topology and versatile Rashba-split surface state configurations in 2M-WS2 and 2M-WSe2

The 2⁢M-phase transition metal dichalcogenides have recently attracted intensive research interest due to their rich topological and superconducting phase diagrams. Apart from the topological surface states of 2⁢M−W⁢S2 near Γ that originated from the strong topological order, using angle-resolved photoemission spectroscopy, we discover additional Rashba-split states on the surfaces of both 2⁢M−W⁢S2 and 2⁢M−WSe2, which extend in large momentum-energy regions. First-principles calculations well reproduce these states and attribute them to the weak topological orders. The calculations further indicate that the surface state connecting configurations are tunable under moderate pressure, suggesting that 2⁢M−W⁢S2 and WSe2 are promising platforms to study topological phase transition and explore topological superconductivity

Bioanalytical assay development and validation for the pharmacokinetic study of gmc1, a novel fkbp52 co-chaperone inhibitor for castration resistant prostate cancer

Background: GMC1 (2-(1H-benzimidazol-2-ylsulfanyl)-N-[(Z)-(4-methoxyphenyl) methylideneamino] acetamide) effectively inhibits androgen receptor function by binding directly to FKBP52. This is a novel mechanism for the treatment of castration resistant prostate cancer (CRPC). Methods: an LC-MS/MS method was developed and validated to quantify GMC1 in plasma and urine from pharmacokinetics studies in rats. An ultra-high-performance liquid chromatography (UHPLC) system equipped with a Waters XTerra MS C18 column was used for chromatographic separation by gradient elution with 0.1% (v/v) formic acid in water and methanol. A Sciex 4000 QTRAP® mass spectrometer was used for analysis by multiple reaction monitoring (MRM) in positive mode; the specific ions [M+H]+ m/z 340.995 → m/z 191.000 and [M+H]+ m/z 266.013 → m/z 234.000 were monitored for GMC1 and internal standard (albendazole), respectively. Results: GMC1 and albendazole had retention times of 1.68 and 1.66 min, respectively. The calibration curves for the determination of GMC1 in rat plasma and urine were linear from 1–1000 ng/mL. The LC-MS/MS method was validated with intra-and inter-day accuracy and precision within the 15% acceptance limit. The extraction recovery values of GMC1 from rat plasma and urine were greater than 95.0 ± 2.1% and 97.6 ± 4.6%, respectively, with no significant interfering matrix effect. GMC1 is stable under expected sample handling, storage, preparation and LC-MS/MS analysis conditions. Conclusions: Pharmacokinetic evaluation of GMC1 revealed that the molecule has a biexponential disposition in rats, is distributed rapidly and extensively, has a long elimination half-life, and appears to be eliminated primarily by first order kinetics