El litoral ¿objeto de consumo o e planificación? Una comparación entre Córcega y Baleares

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Giant peroxisomes in a moss (Physcomitrella patens) peroxisomal biogenesis factor 11 mutant

Peroxisomal biogenesis factor 11 (PEX11) proteins are found in yeasts, mammals and plants, and play a role in peroxisome morphology and regulation of peroxisome division. The moss Physcomitrella patens has six PEX11 isoforms which fall into two subfamilies, similar to those found in monocots and dicots. We carried out targeted gene disruption of the Phypa_PEX11-1 gene and compared the morphological and cellular phenotypes of the wild-type and mutant strains. The mutant grew more slowly and the development of gametophores was retarded. Mutant chloronemal filaments contained large cellular structures which excluded all other cellular organelles. Expression of fluorescent reporter proteins revealed that the mutant strain had greatly enlarged peroxisomes up to 10 μm in diameter. Expression of a vacuolar membrane marker confirmed that the enlarged structures were not vacuoles, or peroxisomes sequestered within vacuoles as a result of pexophagy. Phypa_PEX11 targeted to peroxisome membranes could rescue the knock out phenotype and interacted with Fission1 on the peroxisome membrane. Moss PEX11 functions in peroxisome division similar to PEX11 in other organisms but the mutant phenotype is more extreme and environmentally determined, making P. patens a powerful system in which to address mechanisms of peroxisome proliferation and division

Caracterização dos macrófagos presentes nas lesões cutâneas da hanseníase: estudo por monoclonais

As lesões cutâneas de 16 pacientes com hanseníase foram estudadas por imunofluorescência com anticorpos monoclonais anti-monócitos (OKM1 e anti-MO) e anti-Ia (OKIa). Foi avaliada a atividade de fosfatase ácida utilizando-se naftol AS-B1 fosfato como substrato. Os macrófagos parecem constituir uma população heterogênea em relação aos antigenos estudados neste trabalho e quanto a atividade enzimática. Em todas as formas estudadas um grande número de células eram OKIa positivas

Compte rendu d'ouvrage " Ibiza mon amour : enquête sur l'industrialisation du plaisir "

Compte rendu d'ouvrage " Ibiza mon amour : enquête sur l'industrialisation du plaisir

Ibiza mon amour : enquête sur l’industrialisation du plaisir

Dans l’Art à l’état gazeux (2003), Yves Michaux, philosophe, fondateur de l’université de tous les savoirs, spécialiste de l’esthétique relevait déjà l’impact énorme du tourisme sur de nombreux aspects de la vie et notamment, sa capacité à mettre en valeur tout autant qu’à détruire. L’auteur présentait cette activité comme une expérience esthétique : le touriste étant à la recherche de sensations, hors de tout intérêt utilitaire pour simplement en jouir. Cette recherche d’hédonisme, au traver..