Types and indices of the extensible database management system, MODUS

Thesis (Ph.D. in Engineering)--University of Tsukuba, (A), no. 1115, 1993.3.2

Totally normal cellular stratified spaces and applications to the configuration space of graphs

The notion of regular cell complexes plays a central role in topological combinatorics because of its close relationship with posets. A generalization, called totally normal cellular stratified spaces, was introduced by the third author by relaxing two conditions; face posets are replaced by acyclic categories and cells with incomplete boundaries are allowed. The aim of this article is to demonstrate the usefulness of totally normal cellular stratified spaces by constructing a combinatorial model for the configuration space of graphs. As an application, we obtain a simpler proof of Ghrist's theorem on the homotopy dimension of the configuration space of graphs. We also make sample calculations of the fundamental group of ordered and unordered configuration spaces of two points for small graphs.Comment: 44 pages. v2. Typos fixed. Accepted for publication by Topological Methods in Nonlinear Analysi

Fluvoxamine for blonanserin-associated akathisia in patients with schizophrenia: report of five cases

BACKGROUND: Atypical antipsychotic drugs have been reported to cause fewer incidences of extrapyramidal side effects (EPS) than typical antipsychotic drugs, but adverse events such as akathisia have been observed even with atypical antipsychotic drugs. Although understanding of the pathophysiology of akathisia remains limited, it seems that a complex interaction of several neurotransmitter systems plays a role in its pathophysiology. The endoplasmic reticulum protein sigma-1 receptors have been shown to regulate a number of neurotransmitter systems in the brain. METHODS: We report on five cases in which monotherapy of the selective serotonin reuptake inhibitor and sigma-1 receptor agonist fluvoxamine was effective in ameliorating the akathisia of patients with schizophrenia treated with the new atypical antipsychotic drug blonanserin. RESULTS: The global score on the Barnes Akathisia Scale in five patients with schizophrenia treated with blonanserin rapidly decreased after fluvoxamine treatment. CONCLUSION: Doctors should consider that fluvoxamine may be an alternative approach in treating akathisia associated with atypical antipsychotic drugs

Use of Chitosan-Siloxane Porous Hybrid Scaffold as Novel Burr Hole Covers

Chitosan-siloxane porous hybrids have high potential as tissue scaffolds. This manuscript focuses on the regeneration of skull bone after a burr hole. This was done using hybrids incorporated with calcium or coated with hydroxyapatite after soaking in a phosohate solution. The specimens fitted the burr hole and the cells migrated into the pores form surrounding bone tissue. After implanation no inflammation was observed and the specimens degraded 12 months later. A coating of hydroxyapatite accelerated bone formation compared

Studies on the ocular hypotensive effect of Diamox

In our studies on the hypotensive effect of Diamox by intravenous injection, we have arrived at the following conclusions. 1. Ocular tension falls and the flow of aqueous humor becomes sluggish. 2. Diamox inhibits the activity of carbonic anhydrase, and the concentrations of HCO3-, K+, Cl- and glucose are markedly altered. 3. Protein increases both in blood and aqueous humor, but no change in protein fraction can be observed in blood. 4. Diamox in no way affects the metabolism. 5. It seems that Diamox brings about the change in the specific gravity of blood, making the latter either more diluted or more concentrated. From these, we conclude that the mechanism of the loweing of ocular tension by Diamox seems to lie in the fact that it inhibits the activity of carbonic anhydrase, and that consequent alteration in the concentrations of HCO3- and other ions accompanied by the change in osmotic pressure as well as a slight decrease of water in tissue all bring about the fall in the ocular tension. However, Diamox seems to have nothing to do with aqueous humor in so far as active transport or permeability are concerned.</p