A comparison of the illness beliefs of people with angina and their peers: a questionnaire study

BACKGROUND: What people believe about their illness may affect how they cope with it. It has been suggested that such beliefs stem from those commonly held within society . This study compared the beliefs held by people with angina, regarding causation and coping in angina, with the beliefs of their friends who do not suffer from angina. METHODS: Postal survey using the York Angina Beliefs Questionnaire (version 1), which elicits stress attributions and misconceived beliefs about causation and coping. This was administered to 164 people with angina and their non-cohabiting friends matched for age and sex. 132 people with angina and 94 friends completed the questionnaire. RESULTS: Peers are more likely than people with angina to believe that angina is caused by a worn out heart (p <0.01), angina is a small heart attack (p = 0.02), and that it causes permanent damage to the heart (p <0.001). Peers were also more likely to believe that people with angina should take life easy (p <0.01) and avoid exercise (p = 0.04) and excitement (p <0.01). CONCLUSIONS: The beliefs of the peer group about causation and coping in angina run counter to professional advice. Over time this may contribute to a reduction in patient concordance with risk factor reduction, and may help to create cardiac invalids

Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria

The uptake and metabolism of the disaccharide trehalose by Mycobacterium tuberculosis is essential for the virulence of this pathogen. Here we describe the chemoenzymatic synthesis of new azido-functionalised asymmetric trehalose probes that resist degradation by mycobacterial enzymes and are used to probe trehalose processing pathways in mycobacteria

Deglaciation and ice shelf development at the northeast margin of the Laurentide Ice Sheet during the Younger Dryas chronozone

Core 2011804‐0010 from easternmost Lancaster Sound provides important insights into deglacial timing and style at the marine margin of the NE Laurentide Ice Sheet (LIS). Spanning 13.2–11.0 cal. ka BP and investigated for ice‐rafted debris (IRD), foraminifera, biogenic silica and total organic carbon, the stratigraphy comprises a lithofacies progression from proximal grounding line and sub‐ice shelf environments to open glaciomarine deposition; a sequence similar to deposits from Antarctic ice shelves. These results are the first marine evidence of a former ice shelf in the eastern Northwest Passage and are consistent with a preceding phase of ice streaming in eastern Lancaster Sound. Initial glacial float‐off and retreat occurred >13.2 cal. ka BP, followed by formation of an extensive deglacial ice shelf during the Younger Dryas, which acted to stabilize the retreating margin of the NE LIS until 12.5 cal. ka BP. IRD analyses of sub‐ice shelf facies indicate initial high input from source areas on northern Baffin Island delivered to Lancaster Sound by a tributary ice stream in Admiralty Inlet. After ice shelf break‐up, Bylot Island became the dominant source area. Foraminifera are dominated by characteristic ice‐proximal glaciomarine benthics (Cassidulina reniforme, Elphidium excavatum f. clavata), complemented by advected Atlantic water (Cassidulina neoteretis, Neogloboquadrina pachyderma) and enhanced current indicators (Lobatula lobatula). The biostratigraphy further supports the ice shelf model, with advection of sparse faunas beneath the ice shelf, followed by increased productivity under open water glaciomarine conditions. The absence of Holocene sediments in the core suggests that the uppermost deposits were removed, most likely due to mass transport resulting from the site's proximity to modern tidewater glacier margins. Collectively, this study presents important new constraints on the deglacial behaviour of the NE Laurentide Ice Sheet, with implications for past ice sheet stability, ice‐rafted sediment delivery, and ice−ocean interactions in this complex archipelago setting

A GFP-strategy for efficient recombinant protein overexpression and purification in Mycobacterium smegmatis

One of the major obstacles to obtaining a complete structural and functional understanding of proteins encoded by the Mycobacterium tuberculosis (Mtb) pathogen is due to significant difficulties in producing recombinant mycobacterial proteins. Recent advances that have utilised the closely related Mycobacterium smegmatis species as a native host have been effective. Here we have developed a method for the rapid screening of both protein production and purification strategies of mycobacterial proteins in whole M. smegmatis cells following green fluorescent protein (GFP) fluorescence as an indicator. We have adapted the inducible T7-promoter based pYUB1062 shuttle vector by the addition of a tobacco etch virus (TEV) cleavable C-terminal GFP enabling the target protein to be produced as a GFP-fusion with a poly-histidine tag for affinity purification. We illustrate the advantages of a fluorescent monitoring approach with the production and purification of the mycobacterial N-acetylglucosamine-6-phosphate deacetylase (NagA)-GFP fusion protein. The GFP system described here will accelerate the production of mycobacterial proteins that can be used to understand the molecular mechanisms of Mtb proteins and facilitate drug discovery efforts

Adapting history: applying adaptation theory to historical film and television

This thesis argues that historical films and television programmes help generate new interpretations of the past, even when they depart from a common interpretation of how history is generally understood. In order to do this a variety of films and television programmes are analysed through the lens of adaptations studies. This thesis presents an analysis of current research in adaptation studies, alongside contemporary research into historical film. Four questions concerning historical adaptation are identified through which an original contribution to existing knowledge is made. These questions are: a)To what extent is an adaptation’s presentation of the past aware of the context of the depicted historical events? b) How can the addition of elements which were not present within the surviving sources, for example anachronisms, function within a historical adaptation? c) How can an adaptation promote a new interpretation of the events which are the focus of the adaptation, as well as how those events relate to the present? d) How can an adaptation be used to inform, critique, or aid in an audience’s understanding of history? The ideas that emerge from a literature review are explored over the course of four separate, but interrelated, case studies. These case studies each focusing on a different aspect of historical adaptation. The results are then combined in the conclusion in order to create a cohesive, central argument about the potential benefits of historical adaptation in film and television

Fan phenomena: Harry Potter (Review)

Review of the book "Fan Phenomena: Harry Potter"