Direct-Immersion Solid-Phase Microextraction (SPME) and GC-ECD of Benzophenones for Detection of Benzodiazepines and Their Derivatives in Urine

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A DEATH CASE IN WHICH THE VICTIM WAS RUN OVER AFTER INTAKE OF PSYCHOPHARMACEUTICAL DRUGS INCLUDING CARBAMAZEPINE

A curious case, in which a 60-year old male was run over and killed after intake of psychopharmaceuticals including carbamazepine, is presented. By forensic autopsy, the cause of his death was judged to be an injury of the pons. The concentrations of carbamazepine in whole blood and urine were found to be 8.55 and 2.76μg/ml, respectively. He seemed to have lain down on the road under drowsy state due to the intake of carbamazepine and flunitrazepam, just before the traffic accident.journal articl

SIMPLE EXTRACTION OF 1-PHENYLETHYLAMINE IN HUMAN URINE BY HEADSPACE SOLID PHASE MICROEXTRACTION (SPME)

A method for simple clean-up of 1-phenylethylamine (1-PEA. α-phenylethylamine. α-methylbenzylamine). a possible abused drug. in human urine by headspace solid phase microextraction (SPME) with a polydimethylsiloxane-divinylbenzene fiber. is presented. Quantitation was made by capillary gas chromatography with nitrogen-phosphorus detection and β-methylphenethylamine was used as internal standard (IS). The recoveries of 1-PEA and IS were 4.75 to 8.93% and 13.4%. respectively. The calibration curve for 1-PEA was linear in the range of 25-500 ng/ml urine. The detection limit was about 20 ng/ml urine.journal articl