Europe's lost forests: a pollen-based synthesis for the last 11,000 years

8000 years ago, prior to Neolithic agriculture, Europe was mostly a wooded continent. Since then, its forest cover has been progressively fragmented, so that today it covers less than half of Europe’s land area, in many cases having been cleared to make way for fields and pasture-land. Establishing the origin of Europe’s current, more open land-cover mosaic requires a long-term perspective, for which pollen analysis offers a key tool. In this study we utilise and compare three numerical approaches to transforming pollen data into past forest cover, drawing on >1000 14C-dated site records. All reconstructions highlight the different histories of the mixed temperate and the northern boreal forests, with the former declining progressively since ~6000 years ago, linked to forest clearance for agriculture in later prehistory (especially in northwest Europe) and early historic times (e.g. in north central Europe). In contrast, extensive human impact on the needle-leaf forests of northern Europe only becomes detectable in the last two millennia and has left a larger area of forest in place. Forest loss has been a dominant feature of Europe’s landscape ecology in the second half of the current interglacial, with consequences for carbon cycling, ecosystem functioning and biodiversity

Twitter: an emerging source for geographical study

In 2004, the term ‘Web 2.0’ was coined to describe the new way in which users were consuming the Internet (Kaplan and Haenlein, 2010). It was on this new platform that the evolution of social media took place and consequently, the production of user generated content on a scale not previously seen (Kaplan and Haenlein, 2010). Twitter is among the array of social media sites and is currently the fastest growing and most popular microblogging site in the world (Atefeh and Khreich, 2015)

The response of the Antarctic Circumpolar Current to recent climate change

Observations show a significant intensification of the Southern Hemisphere westerlies, the prevailing winds between the latitudes of 30° and 60° S, over the past decades. A continuation of this intensification trend is projected by climate scenarios for the twenty-first century. The response of the Antarctic Circumpolar Current and the carbon sink in the Southern Ocean to changes in wind stress and surface buoyancy fluxes is under debate. Here we analyse the Argo network of profiling floats and historical oceanographic data to detect coherent hemispheric-scale warming and freshening trends that extend to depths of more than 1,000 m. The warming and freshening is partly related to changes in the properties of the water masses that make up the Antarctic Circumpolar Current, which are consistent with the anthropogenic changes in heat and freshwater fluxes suggested by climate models. However, we detect no increase in the tilt of the surfaces of equal density across the Antarctic Circumpolar Current, in contrast to coarse-resolution model studies. Our results imply that the transport in the Antarctic Circumpolar Current and meridional overturning in the Southern Ocean are insensitive to decadal changes in wind stress

Role of recent climate change on carbon sequestration in peatland systems.

This paper provides information on the impact of recent climate change on carbon sequestration in peatland systems in South West England. This is important because peatlands have the potential to sequester and hold large quantities of anthropogenically released CO2. This paper investigates whether there has been a reduction in the strength of carbon sinks in a valley mire and blanket bog, which occur on the limits of the biogeographical envelop for peatlands in Britain. Past rates of carbon accumulation were calculated from peat depth and the sequential analysis of peat age, bulk density and carbon content from cores taken from valley mire and blanket bog. At the valley mire site contemporary net ecosystem carbon balance (NECB) was calculated by measuring inputs to the peat body, via net primary productivity (NPP), of Sphagna. Losses of C from the peat body were calculated by measuring CH4, and aquatic carbon, calculated from catchment export of particulate and dissolved organic carbon. The study found similar mean rates of carbon accumulation since 1850 of 11.26 t ± 0.68 t CO2e ha-1 yr-1 (307 g C m-2 yr-1) in valley mire and 11.77 t ± 0.88 t CO2e ha-1 yr-1 (321 g C m-2 yr-1) in blanket bog. The mean present-day CO2 sequestration rate for Sphagna on valley mire was calculated to be 9.13 t ± 0.98 t CO2e ha-1 yr-1 (249 g C m-2 yr-1). Both past and contemporary rates of CO2 sequestration were found to be at the maxima of those reported for temperate peatlands. NPP was found to vary according to microform with higher rates of carbon sequestration found in lawn and hummock microforms compared with pools. Our work suggests that recent changes in the climate appear to have had limited impact on the strength of peatland carbon sinks in South West England

Mathematical modelling of polyamine metabolism in bloodstream-form trypanosoma brucei: An application to drug target identification

© 2013 Gu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedThis article has been made available through the Brunel Open Access Publishing Fund.We present the first computational kinetic model of polyamine metabolism in bloodstream-form Trypanosoma brucei, the causative agent of human African trypanosomiasis. We systematically extracted the polyamine pathway from the complete metabolic network while still maintaining the predictive capability of the pathway. The kinetic model is constructed on the basis of information gleaned from the experimental biology literature and defined as a set of ordinary differential equations. We applied Michaelis-Menten kinetics featuring regulatory factors to describe enzymatic activities that are well defined. Uncharacterised enzyme kinetics were approximated and justified with available physiological properties of the system. Optimisation-based dynamic simulations were performed to train the model with experimental data and inconsistent predictions prompted an iterative procedure of model refinement. Good agreement between simulation results and measured data reported in various experimental conditions shows that the model has good applicability in spite of there being gaps in the required data. With this kinetic model, the relative importance of the individual pathway enzymes was assessed. We observed that, at low-to-moderate levels of inhibition, enzymes catalysing reactions of de novo AdoMet (MAT) and ornithine production (OrnPt) have more efficient inhibitory effect on total trypanothione content in comparison to other enzymes in the pathway. In our model, prozyme and TSHSyn (the production catalyst of total trypanothione) were also found to exhibit potent control on total trypanothione content but only when they were strongly inhibited. Different chemotherapeutic strategies against T. brucei were investigated using this model and interruption of polyamine synthesis via joint inhibition of MAT or OrnPt together with other polyamine enzymes was identified as an optimal therapeutic strategy.The work was carried out under a PhD programme partly funded by Prof. Ray Welland, School of Computing Science, University of Glasgo

Quantified moorland vegetation and assessment of the role of burning over the past five millennia

© 2017 International Association for Vegetation Science. Aims: To apply the Landscape Reconstruction Algorithm (LRA) to pollen count data from multiple sites to estimate local vegetation abundance and compare with charcoal-derived records of burning. Location: Exmoor, southwest England, UK. Methods: Pollen count data from 16 sites were transformed to estimates of distance-weighted vegetation abundance using the LRA (REVEALS and LOVE models), correcting for bias in pollen production and dispersal. Charcoal concentration data from six sites were normalized using Box-Cox transformation to produce z-scores. Moving-window correlation was undertaken to compare pollen percentage values for key taxa (Calluna, Poaceae) and localized burning. Estimates of distance-vegetation abundance (LRA output) and time-averaged charcoal z-scores were compared to assess the role of burning as a driver for upland vegetation cover. Results: Comparison of pollen percentage and normalized charcoal z-scores show little correlation between vegetation cover and burning. Estimates of distance-weighted vegetation abundance and normalized charcoal data show relationships between vegetation change and burning at four of the six sites. The relationships are site-specific: three sites suggest burning promoted grass-dominated vegetation, at one site burning promoted heather-dominated vegetation, and in two sites there is no apparent relationship. Conclusions: The patterning of vegetation within uplands is a crucial part of ecosystem service delivery, and contemporary and future management benefits from understanding of 'long-term' development, i.e. patterns over millennia. The correction of biases within pollen production and dispersal to produce local vegetation estimates has demonstrated spatial heterogeneity in vegetation cover on Exmoor that is not otherwise evident in the pollen percentage data (which retain a strong influence of the regional vegetation cover). The relationship between LRA-derived vegetation cover and burning is not apparent in comparisons between pollen percentage data and charcoal records. This implies that studies that use pollen proportional data alone can misrepresent the relationship between vegetation cover and fire. This study demonstrates that fire has been an important part of the development of this cultural landscape

Early invaders - Farmers, the granary weevil and other uninvited guests in the Neolithic

The Neolithic and the spread of agriculture saw several introductions of insect species associated with the environments and activities of the first farmers. Fossil insect research from the Neolithic lake settlement of Dispilio in Macedonia, northern Greece, provides evidence for the early European introduction of a flightless weevil, the granary weevil, Sitophilus granarius, which has since become cosmopolitan and one of the most important pests of stored cereals. The records of the granary weevil from the Middle Neolithic in northern Greece illuminate the significance of surplus storage for the spread of agriculture. The granary weevil and the house fly, Musca domestica were also introduced in the Neolithic of central Europe, with the expansion of Linear Band Keramik (LBK) culture groups. This paper reviews Neolithic insect introductions in Europe, including storage pests, discusses their distribution during different periods and the reasons behind the trends observed. Storage farming may be differentiated from pastoral farming on the basis of insect introductions arriving with incoming agricultural groups

Mapping upland peat depth using airborne radiometric and lidar survey data

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.A method to estimate peat depth and extent is vital for accurate estimation of carbon stocks and to facilitate appropriate peatland management. Current methods for direct measurement (e.g. ground penetrating radar, probing) are labour intensive making them unfeasible for capturing spatial information at landscape extents. Attempts to model peat depths using remotely sensed data such as elevation and slope have shown promise but assume a functional relationship between current conditions and gradually accrued peat depth. Herein we combine LiDAR-derived metrics known to influence peat accumulation (elevation, slope, topographic wetness index (TWI)) with passive gamma-ray spectrometric survey data, shown to correlate with peat occurrence to develop a novel peat depth model for Dartmoor. Total air absorbed dose rates of Thorium, Uranium and Potassium were calculated, referred to as radiometric dose. Relationships between peat depth, radiometric dose, elevation, slope and TWI were trained using 1334 peat depth measurements, a further 445 measurements were used for testing. All variables showed significant relationships with peat depth. Linear stepwise regression of natural log-transformed variables indicated that a radiometric dose and slope model had an r2 = 0.72/0.73 and RMSE 0.31/0.31 m for training/testing respectively. This model estimated an area of 158 ±101 km2 of peaty soil >0.4 m deep across the study area. Much of this area (60 km2) is overlain by grassland and therefore may have been missed if vegetation cover was used to map peat extent. Using published bulk density and carbon content values we estimated 13.1 Mt C (8.1-21.9 Mt C) are stored in the peaty soils within the study area. This is an increase on previous estimates due to greater modelled peat depth. The combined use of airborne gamma-ray spectrometric survey and LiDAR data provide a novel, practical and repeatable means to estimate peat depth with no a priori knowledge, at an appropriate resolution (10 m) and extent (406 km2) to facilitate management of entire peatland complexes.The authors would like to thank the anonymous reviewers for the thorough reviews, their suggestions improved this paper. This work was supported by South West Water [SK06855], Dartmoor National Park Authority [SK07279] and the South West Partnership for Environmental and Economic Prosperity (SWEEP). SWEEP was funded by the Natural Environment Research Council (NE/P011217/1)

Kualitas Hidup Pasien Diabetes Melitus Tipe 2 di Puskesmas Se Kota Kupang

Diabetes Mellitus is well known as a chronic disease which can lead to a decrease in quality of life in all domains. The study aims to explore the diabetic type 2 patient\u27s quality of life and find out the factors affecting in type 2 diabetic mellitus patients. The cross-sectional study design is used that included 65 patient with type 2 diabetes mellitus, in 11 public health centers of Kupang City. Data were collected by using Short Form Survey (SF-36) that assessed 8-scale health profile. Independent sample t-test is used to analyze the correlation between the factors affecting and the quality of life. the study showed that the QoL of DM patients decreased in all 8- health profile including physical functioning, social functioning, mental health, general health, pain, change in the role due to physical problems and emotional problems. The Study also showed there was a relationship between gender, duration of suffering from Diabetes mellitus, and complications to the quality of life. Male perceived a better quality of life than female