Ferromagnetic tunneling junctions at low voltages: elastic versus inelastic scattering at T=0KT=0 K

In this paper we analyze different contributions to the magnetoresistance of magnetic tunneling junctions at low voltages. A substantial fraction of the resistance drop with voltage can be ascribed to variations of the density of states and the barrier transmission with the bias. However, we found that the anomaly observed at zero bias and the magnetoresistance behavior at very small voltages, point to the contribution of inelastic magnon-assisted tunneling. The latter is described by a transfer parameter $T^{J}$, which is one or two orders of magnitude smaller than $T^{d}$, the direct transmission for elastic currents. Our theory is in excellent agreement with experimental data, yielding estimated values of $T^{J}$ which are of the order of $T^{d}$ / $T^{J}$ ~ 40.Comment: 13 pages, 4 figures (in postscript format). PACS numbers: 72.25.-b, 73.23.-b, 72.10.D

Measuring Red Blood Cell Velocity with a Keyhole Tracking Algorithm

A tracking algorithm is proposed to measure the velocity of red blood cells traveling through microvessels of tumors growing in skin flaps implanted on mice. The tracking is based on a keyhole model that describes the probable movement of a segmented cell between contiguous frames in a video sequence. When a history of movements exists, past, present and a predicted landing position define two regions of probability with a keyhole shape. This keyhole is used to de- termine if cells in contiguous frames should be linked to form tracks. Pre-processing segments cells from background and post-processing joins tracks and discards links that could have been formed due to noise or uncertainty. The algorithm pre- sents several advantages over traditional methods such as kymographs or particle image velocimetry: manual interven- tion is restricted to the thresholding, several vessels can be analyzed simultaneously, algorithm is robust to noise and a wealth of statistical measures can be obtained. Two tumors with different geometries were analyzed; average velocities were 211±136 [μm/s] (mean±std) with a range 15.9-797 [μm/s], and 89±62 [μm/s] with a range 5.5-300 [μm/s] respec- tively, which are consistent with previous results in the litera- ture

A scale-space tracing algorithm for analysis of tumour blood vessel morphology from transmitted light optical images

Background Limited contrast in optical images is problematic for analysing tumour vascular morphology. We describe an algorithm for segmenting tumour vasculature in transmitted light optical images, without the need for contrast enhancement. Effects of angiopoietin-1 (Ang-1) and -2 (Ang-2) ± treatment with the vascular disrupting agent combretastatin A4P (CA4P) were investigated. Method SW1222 human colorectal carcinoma cells were transfected with Ang-1 or Ang-2 cDNA, or with empty vector and implanted into ‘window’ chamber-bearing mice. Transmitted light images of tumours (x10 objective) were acquired before and up to 24h after treatment with 30 mg/kg CA4P or saline. Vessel tracing used a scale-space approach, employing differences in intensity of transmitted light between the vessels and surrounding tissues, as well as differences in the chromatic components, hue and saturation. The centreline of vessels was detected as a “ridge” in a topographical analogy and successive levels of filtering provided different scales to detect sharp to diffuse ridges. Morphological parameters were measured from the traced images - average vessel length (AL) width (AW), and relative vascular area (RA). Results The algorithm successfully identified the majority of tumour microvessels. CA4P-treated tumours showed a decrease in RA and increase in saturation balance up to 1-3h, with recovery by 24h. Saline had no effect. Ang-2 over-expressing tumours had lower values of AL, AW and RA than Ang-1 and wild-type (WT) tumours. Ang-1 tumours were similar to the WT except that AL was longer

Segmentation and morphological analysis of microvessels in immunostained histological tumour sections

Segmentation and morphological analysis of microvessels in immunostained histological tumour sectionsA fully automatic segmentation and morphological analysis algorithm for the analy- sis of microvessels from CD31 immunostained histological tumour sections is presented. The algorithm exploited the distinctive hues of stained vascular endothelial cells, cell nuclei and background, which provided the seeds for a region-growing algorithm in the 3D Hue, Saturation, Value (HSV) colour model. The segmented objects, identified as microvessels by CD31 immunostaining, were post-processed with three morphological tasks: joining separate objects that were likely to belong to a single vessel, closing ob- jects that had a narrow gap around their periphery, and splitting objects with multiple lumina into individual vessels

High-fidelity state detection and tomography of a single ion Zeeman qubit

We demonstrate high-fidelity Zeeman qubit state detection in a single trapped 88 Sr+ ion. Qubit readout is performed by shelving one of the qubit states to a metastable level using a narrow linewidth diode laser at 674 nm followed by state-selective fluorescence detection. The average fidelity reached for the readout of the qubit state is 0.9989(1). We then measure the fidelity of state tomography, averaged over all possible single-qubit states, which is 0.9979(2). We also fully characterize the detection process using quantum process tomography. This readout fidelity is compatible with recent estimates of the detection error-threshold required for fault-tolerant computation, whereas high-fidelity state tomography opens the way for high-precision quantum process tomography

Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to VEGF-R tyrosine kinase inhibition

In this work we studied the functional differences between the microcirculation of murine tumours that only express single isoforms of vascular endothelial growth factor-A (VEGF), VEGF120 and VEGF188, and the effect of VEGF receptor tyrosine kinase (VEGF-R TK) inhibition on their functional response to the vascular disrupting agent, combretastatin A-4 phosphate (CA-4-P). We used measurement of fluorescently- labelled red blood cell (RBC) velocities in tumour microvessels to study this functional response. RBC velocity for control VEGF120-expressing tumours was over 50% slower than for control VEGF188- expressing tumours, which may be due to the immature and haemorrhagic vasculature of the VEGF120 tumour. After chronic treatment with a VEGF-R tyrosine kinase inhibitor, SU5416, RBC velocities in VEGF120 tumours were significantly increased compared to control VEGF120 tumours, and similar to velocities in both VEGF188 treatment groups. Control and SU5416 treated VEGF188 tumours were not different from each other. Treatment of VEGF120 tumours with SU5416 reduced their vascular response to CA-4-P to a similar level to the VEGF188 tumours. Differential expression of VEGF isoforms not only affected vascular function in untreated tumours but also impacted on response to a vascular disrupting drug, CA-4-P, alone and in combination with an anti-angiogenic approach involving VEGF-R TK inhibition. Analysis of RBC velocities is a useful tool in measuring functional responses to vascular targeted treatments

Abundance gradients in the Milky Way for alpha elements, Iron peak elements, Barium, Lanthanum and Europium

We model the abundance gradients in the disk of the Milky Way for several chemical elements (O, Mg, Si, S, Ca, Sc, Ti, Co, V, Fe, Ni, Zn, Cu, Mn, Cr, Ba, La and Eu), and compare our results with the most recent and homogeneous observational data. We adopt a chemical evolution model able to well reproduce the main properties of the solar vicinity. We compute, for the first time, the abundance gradients for all the above mentioned elements in the galactocentric distance range 4 - 22 kpc. The comparison with the observed data on Cepheids in the galactocentric distance range 5-17 kpc gives a very good agreement for many of the studied elements. In addition, we fit very well the data for the evolution of Lanthanum in the solar vicinity for which we present results here for the first time. We explore, also for the first time, the behaviour of the abundance gradients at large galactocentric distances by comparing our results with data relative to distant open clusters and red giants and select the best chemical evolution model model on the basis of that. We find a very good fit to the observed abundance gradients, as traced by Cepheids, for most of the elements, thus confirming the validity of the inside-out scenario for the formation of the Milky Way disk as well as the adopted nucleosynthesis prescriptions.Comment: 11 pages, 9 figures, accepted for publication in A&

The nature of localization in graphene under quantum Hall conditions

Particle localization is an essential ingredient in quantum Hall physics [1,2]. In conventional high mobility two-dimensional electron systems Coulomb interactions were shown to compete with disorder and to play a central role in particle localization [3]. Here we address the nature of localization in graphene where the carrier mobility, quantifying the disorder, is two to four orders of magnitude smaller [4,5,6,7,8,9,10]. We image the electronic density of states and the localized state spectrum of a graphene flake in the quantum Hall regime with a scanning single electron transistor [11]. Our microscopic approach provides direct insight into the nature of localization. Surprisingly, despite strong disorder, our findings indicate that localization in graphene is not dominated by single particle physics, but rather by a competition between the underlying disorder potential and the repulsive Coulomb interaction responsible for screening.Comment: 18 pages, including 5 figure

Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging

Silicon nanoparticles are experimentally investigated as a potential hyperpolarized, targetable MRI imaging agent. Nuclear T_1 times at room temperature for a variety of Si nanoparticles are found to be remarkably long (10^2 to 10^4 s) - roughly consistent with predictions of a core-shell diffusion model - allowing them to be transported, administered and imaged on practical time scales without significant loss of polarization. We also report surface functionalization of Si nanoparticles, comparable to approaches used in other biologically targeted nanoparticle systems.Comment: supporting material here: http://marcuslab.harvard.edu/Aptekar_hyper1_sup.pd

The color excess of quasars with intervening DLA systems- Analysis of the SDSS data release five

We analyzed the spectroscopic and photometric database of the 5th data release of the Sloan Digital Sky Survey (SDSS) to search for evidence of the quasar reddening produced by dust embedded in intervening damped Ly alpha (DLA) systems. From a list of 5164 quasars in the interval of emission redshift 2.25 /= 4, we built up an "absorption sample" of 248 QSOs with a single DLA system in the interval of absorption redshift 2.2 < z_a </= 3.5 and a "pool" of 1959 control QSOs without DLA systems or strong metal systems. For each QSO of the absorption sample we extracted from the pool a subset of control QSOs that are closest in redshift and magnitude. The mean color of this subset was used as a zero point to measure the "deviation from the mean color" of individual DLA-QSOs, Delta_i. The colors were measured using "BEST" ugriz SDSS imaging data. The mean color excess of the absorption sample, , was estimated by averaging the individual color deviations Delta_i. We find = 27 +/- 9 x 10**(-3) mag and = 54 +/- 12 x 10**(-3) mag. These values are representative of the reddening of DLA systems at z_a ~ 2.7 in SDSS QSOs with limiting magnitude r =/~ 20.2. The detection of the mean reddening is confirmed by several statistical tests. Analysis of the results suggests an origin of the reddening in dust embedded in the DLA systems, with an SMC-type extinction curve. By converting the reddening into rest-frame extinction, we derive a mean dust-to-gas ratio ~ 2 to 4 x 10**(-23) mag cm^2. This value is ~ -1.25 dex lower than the mean dust-to-gas ratio of the Milky Way, in line with the lower level of metallicity in the present DLA sample.Comment: Accepted for publication on Astronomy & Astrophysics, 17 pages, 10 figure