AGN feedback at z~2 and the mutual evolution of active and inactive galaxies

The relationships between galaxies of intermediate stellar mass and moderate luminosity active galactic nuclei (AGNs) at 1<z<3 are investigated with the Galaxy Mass Assembly ultra-deep Spectroscopic Survey (GMASS) sample complemented with public data in the GOODS-South field. Using X-ray data, hidden AGNs are identified in unsuspected star-forming galaxies with no apparent signs of non-stellar activity. In the color-mass plane, two parallel trends emerge during the ~2 Gyr between the average redshifts z~2.2 and z~1.3: while the red sequence becomes significantly more populated by ellipticals, the majority of AGNs with L(2-10 keV)>10^42.3 erg s^-1 disappear from the blue cloud/green valley where they were hosted predominantly by star-forming systems with disk and irregular morphologies. These results are even clearer when the rest-frame colors are corrected for dust reddening. At z~2.2, the ultraviolet spectra of active galaxies (including two Type 1 AGNs) show possible gas outflows with velocities up to about -500 km s^-1 that are not observed neither in inactive systems at the same redshift, nor at lower redshifts. Such outflows indicate the presence of gas that can move faster than the escape velocities of active galaxies. These results suggest that feedback from moderately luminous AGNs (logL_X~2 by contributing to outflows capable of ejecting part of the interstellar medium and leading to a rapid decrease in the star formation in host galaxies with stellar masses 10<logM<11 M_Sun.Comment: Astrophysical Journal Letters, in press (6 pages, 4 figures

Laparotomic vs laparoscopic ovariectomy: comparing the two methods. The ovariectomy in the bitch in laparoscopic era

BACKGROUND: The aim of the present work is to evaluate the effectiveness of the use of ultrasound scalpel during laparoscopic ovariectomy in the bitch. METHODS: Two groups of 10 subjects each, of different races and ages, were compared. In the first group, ovariectomy was performed laparoscopically, using harmonic scalpel to remove ovary. In the second group surgery was performed by means of classical laparotomy. RESULTS: Pre-operative time was similar in both groups. Total operative time, from incision to skin suture, showed significant difference between the two groups, being laparoscopy faster than laparotomy. Partial operative time for bilateral oophorectomy resulted lower using open technique, but, considering each ovary, there was no significant difference in both groups. CONCLUSIONS: The use of harmonic scalpel to perform ovariectomy during laparoscopy is an effective time-sparing surgical approach compared to the already great practicality of laparotomy

The extended epoch of galaxy formation: age dating of ~3600 galaxies with 2<z<6.5 in the VIMOS Ultra-Deep Survey

We aim at improving constraints on the epoch of galaxy formation by measuring the ages of 3597 galaxies with spectroscopic redshifts 2<z<6.5 in the VIMOS Ultra Deep Survey (VUDS). We derive ages and other physical parameters from the simultaneous fitting with the GOSSIP+ software of observed UV rest-frame spectra and photometric data from the u-band up to 4.5 microns using composite stellar population models. We conclude from extensive simulations that at z>2 the joint analysis of spectroscopy and photometry combined with restricted age possibilities when taking into account the age of the Universe substantially reduces systematic uncertainties and degeneracies in the age derivation. We find galaxy ages ranging from very young with a few tens of million years to substantially evolved with ages up to ~1.5-2 Gyr. The formation redshifts z_f derived from the measured ages indicate that galaxies may have started forming stars as early as z_f~15. We produce the formation redshift function (FzF), the number of galaxies per unit volume formed at a redshift z_f, and compare the FzF in increasing redshift bins finding a remarkably constant 'universal' FzF. The FzF is parametrized with (1+z)^\zeta, with \zeta~0.58+/-0.06, indicating a smooth 2 dex increase from z~15 to z~2. Remarkably this observed increase is of the same order as the observed rise in the star formation rate density (SFRD). The ratio of the SFRD with the FzF gives an average SFR per galaxy of ~7-17Msun/yr at z~4-6, in agreement with the measured SFR for galaxies at these redshifts. From the smooth rise in the FzF we infer that the period of galaxy formation extends from the highest possible redshifts that we can probe at z~15 down to redshifts z~2. This indicates that galaxy formation is a continuous process over cosmic time, with a higher number of galaxies forming at the peak in SFRD at z~2 than at earlier epochs. (Abridged)Comment: Submitted to A&A, 24 page

Morphological studies of the Spitzer Wide-Area Infrared Extragalactic survey galaxy population in the UGC 10214 Hubble space telescope/advanced camera for surveys field

We present the results of a morphological analysis of a small subset of the Spitzer Wide-Area Infrared Extragalactic survey (SWIRE) galaxy population. The analysis is based on public Advanced Camera for Surveys (ACS) data taken inside the SWIRE N1 field, which are the deepest optical high-resolution imaging available within the SWIRE fields as of today. Our reference sample includes 156 galaxies detected by both ACS and SWIRE. Among the various galaxy morphologies, we disentangle two main classes, spheroids (or bulge-dominated galaxies) and disc-dominated ones, for which we compute the number counts as a function of flux. We then limit our sample to objects with Infrared Array Camera (IRAC) fluxes brighter than 10 μJy, estimated ~90 per cent completeness limit of the SWIRE catalogues, and compare the observed counts to model predictions. We find that the observed counts of the spheroidal population agree with the expectations of a hierarchical model while a monolithic scenario predicts steeper counts. Both scenarios, however, underpredict the number of late-type galaxies. These observations show that the large majority (close to 80 per cent) of the 3.6- and 4.5-μm galaxy population, even at these moderately faint fluxes, is dominated by spiral and irregular galaxies or mergers

Electrospun Polyhydroxyethyl-Aspartamide-Polylactic Acid Scaffold for Biliary Duct Repair: A Preliminary In\ua0Vivo Evaluation

Tissue engineering has emerged as a new approach with the potential to overcome the limitations of traditional therapies. The objective of this study was to test whether our polymeric scaffold is able to resist the corrosive action of bile and to support a cell's infiltration and neoangiogenesis with the aim of using it as a biodegradable tissue substitute for serious bile duct injuries. In particular, a resorbable electrospun polyhydroxyethyl-aspartamide-polylactic acid (90 mol% PHEA, 10 mol% PLA)/polycaprolactone (50:50 w/w) plate scaffold was implanted into rabbit gallbladder to assess the in\ua0vivo effects of the lytic action of the bile on the scaffold structure and then as a tubular scaffold to create a biliary-digestive anastomosis as well. For the above evaluation, 5 animals were used and killed after 15 days and 5 animals after 3 months. At 15-day and 3-month follow-ups, the fibrillar structure was not digested by lytic action bile. The fibers of the scaffold were organized despite being in contact with bile action. A new epithelial tissue appeared on the scaffold surface suggesting the suitability of this scaffold for future studies of the repair of biliary tract injuries with the use of resorbable copolymer on biliary injuries

Electrospun PHEA-PLA/PCL Scaffold for Vascular Regeneration: A Preliminary in\ua0Vivo Evaluation

Background. There is increasing interest in the development of vessel substitutes, and many studies are currently focusing on the development of biodegradable scaffolds capable of fostering vascular regeneration. We tested a new biocompatible and biodegradable material with mechanical properties similar to those of blood vessels. Methods. The material used comprises a mixture of a,b-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) and polylactic acid (PLA), combined with polycaprolactone (PCL) by means of electrospinning technique. Low-molecular-weight heparin was also linked to the copolymer. A tubular PHEA-PLA/PCL sample was used to create an arteriovenous fistula in a pig model with the use of the external iliac vessels. The flow was assessed by means of Doppler ultrasound examination weekly, and 1 month after the implantation we removed the scaffold for histopathologic evaluation. Results. The implants showed a perfect leak-proof seal and adequate elastic tension to blood pressure. About w3 weeks after the implantation, Doppler examination revealed thrombosis of the graft, so we proceeded to its removal. Histologic examination showed chronic inflammation, with the presence of foreign body cells and marked neovascularization. The material had been largely absorbed, leaving some isolated spot residues. Conclusions. The biocompatibility of PHEA-PLA/PCL and its physical properties make it suitable for the replacement of vessels. In the future, the possibility of functionalizing the material with a variety of molecules, to modulate the inflammatory and coagulative responses, will allow obtaining devices suitable for the replacement of native vessels

Constraining The Assembly Of Normal And Compact Passively Evolving Galaxies From Redshift z=3 To The Present With CANDELS

We study the evolution of the number density, as a function of the size, of passive early-type galaxies with a wide range of stellar masses 10^10<M*/Msun<10^11.5) from z~3 to z~1, exploiting the unique dataset available in the GOODS-South field, including the recently obtained WFC3 images as a part of the Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey (CANDELS). In particular, we select a sample of 107 massive (M*>10^10 M_sun), passive (SSFR<10^-2 Gyr^-1) and morphologically spheroidal galaxies at 1.2<z<3, taking advantage of the panchromatic dataset available for GOODS, including VLT, CFHT, Spitzer, Chandra and HST ACS+WFC3 data. We find that at 1<z<3 the passively evolving early-type galaxies are the reddest and most massive objects in the Universe, and we prove that a correlation between mass, morphology, color and star-formation activity is already in place at that epoch. We measure a significant evolution in the mass-size relation of passive early-type galaxies (ETGs) from z~3 to z~1, with galaxies growing on average by a factor of 2 in size in a 3 Gyr timescale only. We witness also an increase in the number density of passive ETGs of 50 times over the same time interval. We find that the first ETGs to form at z>2 are all compact or ultra-compact, while normal sized ETGs (meaning ETGs with sizes comparable to those of local counterparts of the same mass) are the most common ETGs only at z<1. The increase of the average size of ETGs at 0<z<1 is primarily driven by the appearance of new large ETGs rather than by the size increase of individual galaxies.Comment: 9 pages, 5 figures, submitted to Ap

The Cosmic Evolution Survey (COSMOS): a large-scale structure at z=0.73 and the relation of galaxy morphologies to local environment

We have identified a large-scale structure at z~0.73 in the COSMOS field, coherently described by the distribution of galaxy photometric redshifts, an ACS weak-lensing convergence map and the distribution of extended X-ray sources in a mosaic of XMM observations. The main peak seen in these maps corresponds to a rich cluster with Tx= 3.51+0.60/-0.46 keV and Lx=(1.56+/-0.04) x 10^{44} erg/s ([0.1-2.4] keV band). We estimate an X-ray mass within $r500$ corresponding to M500~1.6 x 10^{14} Msun and a total lensing mass (extrapolated by fitting a NFW profile) M(NFW)=(6+/-3) x 10^15 Msun. We use an automated morphological classification of all galaxies brighter than I_AB=24 over the structure area to measure the fraction of early-type objects as a function of local projected density Sigma_10, based on photometric redshifts derived from ground-based deep multi-band photometry. We recover a robust morphology-density relation at this redshift, indicating, for comparable local densities, a smaller fraction of early-type galaxies than today. Interestingly, this difference is less strong at the highest densities and becomes more severe in intermediate environments. We also find, however, local "inversions'' of the observed global relation, possibly driven by the large-scale environment. In particular, we find direct correspondence of a large concentration of disk galaxies to (the colder side of) a possible shock region detected in the X-ray temperature map and surface brightness distribution of the dominant cluster. We interpret this as potential evidence of shock-induced star formation in existing galaxy disks, during the ongoing merger between two sub-clusters.Comment: 15 pages (emulateapj style), 16 figs (low res.); to appear in the ApJ Supplement COSMOS Special Issue. Low-resolution figures; full resolution version available at: http://www.astro.caltech.edu/~cosmos/publications/files/guzzo_0701482.pd

Pancreatic islets from non-heart beating donor pig: Two-layer preservation method in an in vitro porcine model

Purpose: Pancreata from non-heart beating donors could represent an unlimited source of islets if their cell viability can be efficiently preserved during the time necessary to process the organs by the use of a better solution of preservation compared to the classic University of Wisconsin solution. The aim of this study was to determine whether it is possible to obtain functioning "alive islets" from non-heart-beating donors by comparing, on a porcine model, the classic "UW ice-store" method with a two-layer cold storage method (TLM) using oxygenated Perfluorocarbons (PFC) and UW.Methods: Whole pancreata were harvested from 20 NHBDs female pigs with similar characteristics and preserved for 4 h in UW solution (n=10) or TLM (UW/PFC) solution (n=10). The isolated islets were then evaluated for number, viability, purity, and insulin secretion, also estimated after 8 weeks of cryopreservation.Results: The total number of islets obtained from isolation, and their function assayed by the insulin stimulation index, before and after cryopreservation, showed a higher value in the TLM group. No significative differences in terms of purity and viability before and after cryopreservation were found when comparing the two groups.Conclusions: TLM solution for NHBDs porcine pancreata with cold ischemia time lower than 4 h offers significant advantages over UW solution storage, thereby increasing the isolation yield and isolation success rate of the pancreatic porcine islet

Histologic effects of university of wisconsin two-layer method preservation of rat pancreas.

Marginal donors represent a poorly utilized source of organs for transplantation despite their availability. The key is to reduce the ischemic damage in the effort to improve organ quality. This study investigated the histologic effects after in situ perfusion of preservation with a two-layer method compared with the classic University of Wisconsin preservation in term of tissue integrity and number of viable exocrine cells in the rat pancreas both after exsanguination and at 8 weeks of cryopreservation. Pancreata harvested from 60 rats were collected using 3 methods: two-layer method following University of Wisconsin perfusion; exsanguination; and classic University of Wisconsin perfusion/storage. In addition to histologic analysis of collected pancreata, we analyzed the number of CK19(+) cells and their viability using chi-square tests with values P < .05 considered to be significant. Rat pancreas histology showed as University of Wisconsin in situ perfusion and preservation by the two-layer method to be more effective to maintain the morphologic integrity of both exocrine and endocrine tissues. There were a larger number of CK19(+) cells with good viability. Moreover, the effects of oxygenation were visible in pancreas biopsies preserved after exsanguination. In situ University of Wisconsin perfusion and preservation for 240 minutes with the two-layer method yielded greater numbers and viability of CK19(+) cells even after 8 weeks of cryopreservation