Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats

The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinociception of a high-concentration formulation of buprenorphine (Simbadol™) in cats

The First Detailed X-ray Observations of High-Redshift, Optically-Selected Clusters: XMM-Newton Results for Cl 1324+3011 at z = 0.76 and Cl 1604+4304 at z = 0.90

We present the first detailed X-ray observations of optically-selected clusters at high redshift. Two clusters, Cl 1324+3011 at z = 0.76 and Cl 1604+4304 at z = 0.90, were observed with XMM-Newton. The optical center of each cluster is coincident with an extended X-ray source whose emission is detected out to a radius of 0.5 Mpc. The emission from each cluster appears reasonably circular, with some indication of asymmetries and more complex morphologies. Similarly to other optically-selected clusters at redshifts of z > 0.4, both clusters are modest X-ray emitters with bolometric luminosities of only Lx = 1.4 - 2.0 x 10^(44) erg/s. We measure gas temperatures of T = 2.88 (+0.71/-0.49) keV for Cl 1324+3011 and 2.51 (+1.05/-0.69) keV for Cl 1604+4304. The X-ray properties of both clusters are consistent with the high-redshift Lx-T relation measured from X-ray-selected samples at z > 0.5. However, based on the local relations, their X-ray luminosities and temperatures are low for their measured velocity dispersions (sigma). The clusters are cooler by a factor of 2 - 9 compared to the local sigma-T relation. We briefly discuss the possible explanations for these results.Comment: 14 pages, 4 figures; accepted for publication in Astrophysical Journal Letters; version with full resolution figures available at http://bubba.ucdavis.edu/~lubin/xmm.pd

A Very Hot, High Redshift Cluster of Galaxies: More Trouble for Omega_0 = 1

We have observed the most distant (z=0.829) cluster of galaxies in the Einstein Extended Medium Sensitivity Survey, with the ASCA and ROSAT satellites. We find an X-ray temperature of 12.3 +3.1/-2.2 keV for this cluster, and the ROSAT map reveals significant substructure. The high temperature of MS1054-0321 is consistent with both its approximate velocity dispersion, based on the redshifts of 12 cluster members we have obtained at the Keck and the Canada-France-Hawaii telescopes, and with its weak lensing signature. The X-ray temperature of this cluster implies a virial mass ~ 7.4 x 10^14 h^-1 solar masses, if the mean matter density in the universe equals the critical value, or larger if Omega_0 < 1. Finding such a hot, massive cluster in the EMSS is extremely improbable if clusters grew from Gaussian perturbations in an Omega_0 = 1 universe. Combining the assumptions that Omega_0 = 1 and that the intial perturbations were Gaussian with the observed X-ray temperature function at low redshift, we show that the probability of this cluster occurring in the volume sampled by the EMSS is less than a few times 10^{-5}. Nor is MS1054-0321 the only hot cluster at high redshift; the only two other $z > 0.5$ EMSS clusters already observed with ASCA also have temperatures exceeding 8 keV. Assuming again that the initial perturbations were Gaussian and Omega_0 = 1, we find that each one is improbable at the < 10^{-2} level. These observations, along with the fact that these luminosities and temperatures of the high-$z$ clusters all agree with the low-z L_X-T_X relation, argue strongly that Omega_0 < 1. Otherwise, the initial perturbations must be non-Gaussian, if these clusters' temperatures do indeed reflect their gravitational potentials.Comment: 20 pages, 4 figures, To appear in 1 Aug 1998 ApJ (heavily revised version of original preprint

Weak Lensing Detection of Cl 1604+4304 at z = 0.90

We present a weak lensing analysis of the high-redshift cluster Cl 1604+4304. At z=0.90, this is the highest-redshift cluster yet detected with weak lensing. It is also one of a sample of high-redshift, optically-selected clusters whose X-ray temperatures are lower than expected based on their velocity dispersions. Both the gas temperature and galaxy velocity dispersion are proxies for its mass, which can be determined more directly by a lensing analysis. Modeling the cluster as a singular isothermal sphere, we find that the mass contained within projected radius R is 3.69+-1.47 * (R/500 kpc) 10^14 M_odot. This corresponds to an inferred velocity dispersion of 1004+-199 km/s, which agrees well with the measured velocity dispersion of 989+98-76 km/s (Gal & Lubin 2004). These numbers are higher than the 575+110-85 km/s inferred from Cl 1604+4304 X-ray temperature, however all three velocity dispersion estimates are consistent within ~ 1.9 sigma.Comment: Revised version accepted for publication in AJ (January 2005). 2 added figures (6 figures total

Particle acceleration in cooling flow clusters of galaxies: the case of Abell 2626

It has recently been proposed a theoretical model which accounts for the origin of radio mini-halos observed in some cooling flow clusters as related to electron re-acceleration by MHD turbulence (Gitti, Brunetti & Setti 2002). The MHD turbulence is assumed to be frozen into the flow of the thermal ICM and thus amplified in the cooling flow region. Here we present the application of this model to a new mini-halo candidate, the cluster A2626, and compare the results with those obtained for the mini-halo in the Perseus cluster. We present VLA data at 330 MHz and 1.5 GHz of the diffuse radio emission observed in A2626, and we show that its main properties can be explained by the model. We find that the power necessary for the re-acceleration of the relic electron population is only a factor ~ 0.7% of the maximum power that can be extracted by the cooling flow (as estimated on the basis of the standard model). We also discuss the observational properties of known mini-halos in connection with those of host clusters, showing that the radio power of mini--halos increases with the maximum power of cooling flows. This trend is expected in the framework of the model. Possible effects of new Chandra and XMM-Newton estimates of $\dot{M}$ on this trend are considered: we conclude that even if earlier derived cooling rates were overestimated, cooling flow powers are still well above the radio powers emitted by mini-halos.Comment: 12 pages, 11 figures, accepted for publication in Astronomy & Astrophysic

A Collision of Subclusters in Abell 754

We present direct evidence of a collision of subclusters in the galaxy cluster Abell 754. Our comparison of new optical data and archival ROSAT PSPC X-ray data reveal three collision signatures predicted by n-body/hydrodynamical simulations of hierarchical cluster evolution. First, there is strong evidence of a non-hydrostatic process; neither of the two major clumps in the galaxy distribution lies on the off-center peak of the X-ray emission from the intracluster gas. Second, the peak of the X-ray emission is elongated perpendicular to the collision axis defined by the centroids of the two galaxy clumps. Third, there is evidence of compression-heated gas; one of A754's two X-ray temperature components (Henry & Briel 1995) is among the hottest observed in any cluster and hotter than that inferred from the velocity dispersion of the associated galaxy clump. These signatures are consistent with the qualitative features of simulations (Evrard 1990a,b) in which two subclusters have collided in the plane of the sky during roughly the last Gyr. The detection of such collisions is crucial for understanding both the dynamics of individual clusters and the underlying cosmology. First, for systems like A754, estimating the cluster X-ray mass from assumptions of hydrostatic equilibrium and isothermality is incorrect and may produce the discrepancies sometimes found between X-ray masses and those derived from gravitational lens models (Babul & Miralda-Escude 1994). Second, the fraction of nearby clusters in which subclusters have collided in the last Gyr is especially sensitive to the mean mass density parameter Omega_0 (cf. Richstone et al. 1992; Evrard et al. 1993; Lacey & Cole 1993). With a large, well-defined cluster sample, it will be possible to place a new and powerful constraint on cosmological models.Comment: 4 pages + 1 color figure (Postscript). Accepted for Publication in ApJ Letter

Group-cluster merging and the formation of starburst galaxies

A significant fraction of clusters of galaxies are observed to have substructure, which implies that merging between clusters and subclusters is a rather common physical process of cluster formation. It still remains unclear how cluster merging affects the evolution of cluster member galaxies. We report the results of numerical simulations, which show the dynamical evolution of a gas-rich late-type spiral in a merger between a small group of galaxies and a cluster. The simulations demonstrate that time-dependent tidal gravitational field of the merging excites non-axisymmetric structure of the galaxy, subsequently drives efficient transfer of gas to the central region, and finally triggers a secondary starburst. This result provides not only a new mechanism of starbursts but also a close physical relationship between the emergence of starburst galaxies and the formation of substructure in clusters. We accordingly interpret post-starburst galaxies located near substructure of the Coma cluster as one observational example indicating the global tidal effects of group-cluster merging. Our numerical results furthermore suggest a causal link between the observed excess of blue galaxies in distant clusters and cluster virialization process through hierarchical merging of subclusters.Comment: 5 pages 3 color figures, ApJL in pres

A Large Mass of H2 in the Brightest Cluster Galaxy in Zwicky 3146

We present the Spitzer/IRS mid-infrared spectrum of the infrared-luminous (L_{IR}=4e11 L_sun) brightest cluster galaxy (BCG) in the X-ray-luminous cluster Z3146 (z=0.29). The spectrum shows strong aromatic emission features, indicating that the dominant source of the infrared luminosity is star formation. The most striking feature of the spectrum, however, is the exceptionally strong molecular hydrogen (H2) emission lines, which seem to be shock-excited. The line luminosities and inferred warm H2 gas mass (~1e10 M_sun) are 6 times larger than those of NGC 6240, the most H2-luminous galaxy at z <~ 0.1. Together with the large amount of cold H2 detected previously (~1e11 M_sun), this indicates that the Z3146 BCG contains disproportionately large amounts of both warm and cold H2 gas for its infrared luminosity, which may be related to the intracluster gas cooling process in the cluster core.Comment: 13 pages, 3 figures, 1 table; Accepted for publication in ApJ