616 research outputs found
B-meson signatures of a Supersymmetric U(2) flavor model
We discuss B-meson signatures of a Supersymmetric U(2) flavor model, with
relatively light (electroweak scale masses) third generation right-handed
scalars. We impose current B and K meson experimental constraints on such a
theory, and obtain expectations for B->X_s gamma, B->X_s glue, B->X_s l+ l-,
B->phi K_s, B_s-B_sbar mixing, and the dilepton asymmetry in B_s. We show that
such a theory is compatible with all current data, and furthermore, could
reconcile the apparent deviations from Standard Model predictions that have
been found in some experiments.Comment: 37 pages, 21 figures, RevTeX4; v.2 - minor modifications to improve
readability. Published versio
Circulating antigen tests and urine reagent strips for diagnosis of active schistosomiasis in endemic areas
Background:
Point-of-care (POC) tests for diagnosing schistosomiasis include tests based on circulating antigen detection and urine reagent strip tests. If they had sufficient diagnostic accuracy they could replace conventional microscopy as they provide a quicker answer and are easier to use.
Objectives:
To summarise the diagnostic accuracy of: a) urine reagent strip tests in detecting activeSchistosoma haematobium infection, with microscopy as the reference standard; and b) circulating antigen tests for detecting active Schistosoma infection in geographical regions endemic for Schistosoma mansoni or S. haematobium or both, with microscopy as the reference standard.
Search methods:
We searched the electronic databases MEDLINE, EMBASE, BIOSIS, MEDION, and Health Technology Assessment (HTA) without language restriction up to 30 June 2014.
Selection criteria
We included studies that used microscopy as the reference standard: for S. haematobium, microscopy of urine prepared by filtration, centrifugation, or sedimentation methods; and for S. mansoni, microscopy of stool by Kato-Katz thick smear. We included studies on participants residing in endemic areas only.
Data collection and analysis:
Two review authors independently extracted data, assessed quality of the data using QUADAS-2, and performed meta-analysis where appropriate. Using the variability of test thresholds, we used the hierarchical summary receiver operating characteristic (HSROC) model for all eligible tests (except the circulating cathodic antigen (CCA) POC for S. mansoni, where the bivariate random-effects model was more appropriate). We investigated heterogeneity, and carried out indirect comparisons where data were sufficient. Results for sensitivity and specificity are presented as percentages with 95% confidence intervals (CI).
Main results;
We included 90 studies; 88 from field settings in Africa. The median S. haematobiuminfection prevalence was 41% (range 1% to 89%) and 36% for S. mansoni (range 8% to 95%). Study design and conduct were poorly reported against current standards.
Tests for S. haematobium
Urine reagent test strips versus microscopy
Compared to microscopy, the detection of microhaematuria on test strips had the highest sensitivity and specificity (sensitivity 75%, 95% CI 71% to 79%; specificity 87%, 95% CI 84% to 90%; 74 studies, 102,447 participants). For proteinuria, sensitivity was 61% and specificity was 82% (82,113 participants); and for leukocyturia, sensitivity was 58% and specificity 61% (1532 participants). However, the difference in overall test accuracy between the urine reagent strips for microhaematuria and proteinuria was not found to be different when we compared separate populations (P = 0.25), or when direct comparisons within the same individuals were performed (paired studies; P = 0.21).
When tests were evaluated against the higher quality reference standard (when multiple samples were analysed), sensitivity was marginally lower for microhaematuria (71% vs 75%) and for proteinuria (49% vs 61%). The specificity of these tests was comparable.
Antigen assay
Compared to microscopy, the CCA test showed considerable heterogeneity; meta-analytic sensitivity estimate was 39%, 95% CI 6% to 73%; specificity 78%, 95% CI 55% to 100% (four studies, 901 participants).
Tests for S. mansoni
Compared to microscopy, the CCA test meta-analytic estimates for detecting S. mansoni at a single threshold of trace positive were: sensitivity 89% (95% CI 86% to 92%); and specificity 55% (95% CI 46% to 65%; 15 studies, 6091 participants) Against a higher quality reference standard, the sensitivity results were comparable (89% vs 88%) but specificity was higher (66% vs 55%). For the CAA test, sensitivity ranged from 47% to 94%, and specificity from 8% to 100% (four studies, 1583 participants).
Authors' conclusions:
Among the evaluated tests for S. haematobium infection, microhaematuria correctly detected the largest proportions of infections and non-infections identified by microscopy.
The CCA POC test for S. mansoni detects a very large proportion of infections identified by microscopy, but it misclassifies a large proportion of microscopy negatives as positives in endemic areas with a moderate to high prevalence of infection, possibly because the test is potentially more sensitive than microscopy
Throughflow and Quadratic Drag Effects on Thermal Convection in a Rotating Porous Layer
A linear stability analysis is implemented to study thermal convective instability in a horizontal fluid-saturated rotating porous layer with throughflow in the vertical direction. The modified Forchheimer-extended Darcy equation that includes the time-derivative and Coriolis terms is employed as a momentum equation. The criterion for the occurrence of direct and Hopf bifurcations is obtained using the Galerkin method. It is shown that if a Hopf bifurcation is possible it always occurs at a lower value of the Darcy–Rayleigh number than the direct bifurcation. Increase in the throughflow strength and inertia parameter is to decrease the domain of Prandtl number up to which Hopf bifurcation is limited but opposite is the trend with increasing Taylor number. The effect of rotation is found to be stabilizing the system, in general. However, in the presence of both rotation and Forchheimer drag a small amount of vertical throughflow as well as inertia parameter show some destabilizing effect on the onset of direct bifurcation; a result of contrast noticed when they are acting in isolation. The existing results in the literature are obtained as limiting cases from the present study
Experimental Investigation on Mechanical Properties of Hemp/E-Glass Fabric Reinforced Polyester Hybrid Composites
This research work has been focusing on Hemp fibers has an alternative reinforcement for fiber reinforced polymer composites due to its eco-friendly and biodegradable characteristics. This work has been carried out to evaluate the mechanical properties of hemp/E-glass fabrics reinforced polyester hybrid composites. Vacuum bagging method was used for the preparation of six different kinds of hemp/glass fabrics reinforced polyester composite laminates as per layering sequences. The tensile, flexural, impact and water absorption tests of these hybrid composites were carried out experimentally according to ASTM standards. It reveals that an addition of E-glass fabrics with hemp fabrics can increase the mechanical properties of composites and decrease the water absorption of the hybrid composites
Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic
Importance The rapidly expanding novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has challenged the medical community to an unprecedented degree. Physicians and health care workers are at added risk of exposure and infection during the course of patient care. Because of the rapid spread of this disease through respiratory droplets, health care workers who come in close contact with the upper aerodigestive tract during diagnostic and therapeutic procedures, such as otolaryngologists–head and neck surgeons, are particularly at risk. A set of safety recommendations was created based on a review of the literature and communications with physicians with firsthand knowledge of safety procedures during the COVID-19 pandemic.
Observations A high number of health care workers were infected during the first phase of the pandemic in the city of Wuhan, China. Subsequently, by adopting strict safety precautions, other regions were able to achieve high levels of safety for health care workers without jeopardizing the care of patients. The most common procedures related to the examination and treatment of upper aerodigestive tract diseases were reviewed. Each category was reviewed based on the potential risk imposed to health care workers. Specific recommendations were made based on the literature, when available, or consensus best practices. Specific safety recommendations were made for performing tracheostomy in patients with COVID-19.
Conclusions and Relevance Preserving a highly skilled health care workforce is a top priority for any community and health care system. Based on the experience of health care systems in Asia and Europe, by following strict safety guidelines, the risk of exposure and infection of health care workers could be greatly reduced while providing high levels of care. The provided recommendations, which may evolve over time, could be used as broad guidance for all health care workers who are involved in the care of patients with COVID-19
Collider Signature of Bulk Neutrinos in Large Extra Dimensions
We consider the collider signature of right-handed neutrinos propagating in
(large) extra dimensions, and interacting with Standard Model fields
only through a Yukawa coupling to the left-handed neutrino and the Higgs boson.
These theories are attractive as they can explain the smallness of the neutrino
mass, as has already been shown. We show that if is bigger than two,
it can result in an enhancement in the production rate of the Higgs boson,
decaying either invisibly or to a anti- quark pair, associated with an
isolated high charged lepton and missing transverse energy at future
hadron colliders, such as the LHC. The enhancement is due to the large number
of Kaluza-Klein neutrinos produced in the final state. The observation of the
signal event would provide an opportunity to distinguish between the normal and
inverted neutrino mass hierarchies, and to determine the absolute scale of
neutrino masses by measuring the asymmetry of the observed event numbers in the
electron and muon channels.Comment: 31 pages, 13 figures. v2: Added discussion on PDF uncertainties,
added reference
SmartEx: a case study on user profiling and adaptation in exhibition booths
An investigation into user profiling and adaptation with exhibition booth as a case study is reported. First a review of the field of exhibitions and trade fairs and a summary introduction to adaptation and profiling are given. We then introduce three criteria for the evaluation of exhibition booth: effectiveness, efficiency and affect. Effectiveness is related the amount of information collected, efficiency is a measurement of the time taken to collect the information, and affect is the perception of the experience and the mood booth visitors have during and after their visit. We have selected these criteria to assess adaptive and profiled exhibition booths, we call smart exhibition (SmartEx). The assessment is performed with an experiment with three test conditions (non-profiled/non adaptive, profiled/non-adaptive and profiled adaptive presentations). Results of the experiment are presented along discussion. While there is significant improvements of effectiveness and efficiency between the two-first test conditions, the improvement is not significant for the last test condition, for reasons explained. As for the affect, the results show that it has an under-estimated importance in people minds and that it should be addressed more carefully
Sneutrino cold dark matter, a new analysis: relic abundance and detection rates
We perform a new and updated analysis of sneutrinos as dark matter
candidates, in different classes of supersymmetric models. We extend previous
analyses by studying sneutrino phenomenology for full variations of the
supersymmetric parameters which define the various models. We first revisit the
standard Minimal Supersymmetric Standard Model, concluding that sneutrinos are
marginally compatible with existing experimental bounds, including direct
detection, provided they compose a subdominant component of dark matter. We
then study supersymmetric models with the inclusion of right-handed fields and
lepton-number violating terms. Simple versions of the lepton-number-violating
models do not lead to phenomenology different from the standard case when the
neutrino mass bounds are properly included. On the contrary, models with
right-handed fields are perfectly viable: they predict sneutrinos which are
compatible with the current direct detection sensitivities, both as subdominant
and dominant dark matter components. We also study the indirect detection
signals for such successful models: predictions for antiproton, antideuteron
and gamma-ray fluxes are provided and compared with existing and future
experimental sensitivities. The neutrino flux from the center of the Earth is
also analyzed.Comment: 72 pages, 50 figures. The version on the archive has low-resolution
figures. The paper with high resolution figures may be found through
http://www.to.infn.it/~arina/papers or
http://www.to.infn.it/~fornengo/Research/paperlist.htm
Role of Ayurveda in rehabilitation of Abhighataja Pakshavadha - A Clinical Management
Traumatic cerebral haemorrhage is an increasingly recognized complication of severe blunt head or neck trauma, more common with patient with motor vehicle accidents, which may lead to complete paralysis, paraplegia, hemiplegia or severe conditions end up with coma. In the present case history, a 43 year aged male patient was in coma stage after he met with RTA and he recovered back with right hemiplegia. So, he was brought for Rehabilitation through Ayurvedic lines of management. Hence for the same, assessments were done through CNS examinations and NIH scoring was adopted to compare the effect before and after the treatment. And specific treatment was planned which includes Panchakarma, diet regimen, Physiotherapy, Shamanoushadhis and was successfully treated with Ayurveda interventions with reference to Pakshavadha line of management as a rehabilitative management and significant results were obtained after 3 follow ups (total duration for 112 days)
Efficacy of Vyaghriharitaki Avaleha in the management of Vataja Kasa w.s.r. to Pulmonary Eosinophilia - An Open Label Randomized Controlled Clinical Trial
Background: Vataja Kasa (cough caused by Vata Dosha) occurs due to Pranavaha Srotodushti (causes of deformity in channels of respiratory system) characterized by dry paroxysmal cough that resembles Pulmonary eosinophilia (PE) with an elevated Absolute eosinophilic count (AEC) and eosinophilic lung infiltration. Vyaghriharitaki Avaleha is mentioned in Ayurveda classics under the context of Kasa (cough). The current study was carried out to assess its efficacy based on literary indications and the need for more potent medications to treat Vataja Kasa. Aim: Evaluation of the efficacy of Vyaghriharitaki Avaleha in the management of Vataja Kasa. Materials and Methods: A randomized, open label, parallel group, active controlled pre and post test clinical study was conducted comprising of 30 subjects. They were randomly allocated into 2 groups, subjects of Group A received Vyaghriharitaki Avaleha 5g BD and subjects of Group B received Vidangadi Churna 5g BD for 30 days. AEC and Signs & symptoms of Vataja Kasa were assessed before (0th day) and after treatment (30th day), after follow up (45th day). The data obtained were recorded, tabulated and statistically analyzed using Unpaired t test, Paired t Test, Mann Whitney U Test, Wilcoxon Signed rank test. Results: Analysis of the data within groups showed statistically highly significant (p<0.01) results and between the groups analysis showed statistically non-significant (p>0.05) results in reducing AEC and signs & symptoms of Vataja Kasa suggesting almost similar action of both drugs. Conclusion: It can be inferred that Vyaghriharitaki Avaleha is as efficient as Vidangadi Churna in the management of Vataja Kasa
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