Three-dimensional viscous flow computations of a circular jet in subsonic and supersonic cross flow

Three-dimensional viscous flow computations are presented for 90 deg injection angle jets in subsonic and supersonic cross flow. Comparisons with experimental data include jet centerline and vortex trajectories for the subsonic cross flow, and surface pressure measurement for the supersonic crossflow case. The vortices induced in the jet/freestream interaction are computed and illustrated. The vortices persist in subsonic flow and die out quickly in supersonic flow. The structure of the shocks in the unconfined supersonic flow is illustrated

Light meson form factors at high Q2Q^2 from lattice QCD

Measurements and theoretical calculations of meson form factors are essential for our understanding of internal hadron structure and QCD, the dynamics that bind the quarks in hadrons. The pion electromagnetic form factor has been measured at small space-like momentum transfer $|q^2| < 0.3$~GeV$^2$ by pion scattering from atomic electrons and at values up to $2.5$~GeV$^2$ by scattering electrons from the pion cloud around a proton. On the other hand, in the limit of very large (or infinite) $Q^2=-q^2$, perturbation theory is applicable. This leaves a gap in the intermediate $Q^2$ where the form factors are not known. As a part of their 12 GeV upgrade Jefferson Lab will measure pion and kaon form factors in this intermediate region, up to $Q^2$ of $6$~GeV$^2$. This is then an ideal opportunity for lattice QCD to make an accurate prediction ahead of the experimental results. Lattice QCD provides a from-first-principles approach to calculate form factors, and the challenge here is to control the statistical and systematic uncertainties as errors grow when going to higher $Q^2$ values. Here we report on a calculation that tests the method using an $\eta_s$ meson, a 'heavy pion' made of strange quarks, and also present preliminary results for kaon and pion form factors. We use the $n_f=2+1+1$ ensembles made by the MILC collaboration and Highly Improved Staggered Quarks, which allows us to obtain high statistics. The HISQ action is also designed to have small discretisation errors. Using several light quark masses and lattice spacings allows us to control the chiral and continuum extrapolation and keep systematic errors in check.Comment: Presented at Lattice 2017, the 35th International Symposium on Lattice Field Theory at Granada, Spain (18-24 June 2017

Charmonium properties from lattice QCD + QED: hyperfine splitting, J/ψJ/\psi leptonic width, charm quark mass and aμca_{\mu}^c

We have performed the first $n_f = 2+1+1$ lattice QCD computations of the properties (masses and decay constants) of ground-state charmonium mesons. Our calculation uses the HISQ action to generate quark-line connected two-point correlation functions on MILC gluon field configurations that include $u/d$ quark masses going down to the physical point, tuning the $c$ quark mass from $M_{J/\psi}$ and including the effect of the $c$ quark's electric charge through quenched QED. We obtain $M_{J/\psi}-M_{\eta_c}$ (connected) = 120.3(1.1) MeV and interpret the difference with experiment as the impact on $M_{\eta_c}$ of its decay to gluons, missing from the lattice calculation. This allows us to determine $\Delta M_{\eta_c}^{\mathrm{annihiln}}$ =+7.3(1.2) MeV, giving its value for the first time. Our result of $f_{J/\psi}=$ 0.4104(17) GeV, gives $\Gamma(J/\psi \rightarrow e^+e^-)$=5.637(49) keV, in agreement with, but now more accurate than experiment. At the same time we have improved the determination of the $c$ quark mass, including the impact of quenched QED to give $\overline{m}_c(3\,\mathrm{GeV})$ = 0.9841(51) GeV. We have also used the time-moments of the vector charmonium current-current correlators to improve the lattice QCD result for the $c$ quark HVP contribution to the anomalous magnetic moment of the muon. We obtain $a_{\mu}^c = 14.638(47) \times 10^{-10}$, which is 2.5$\sigma$ higher than the value derived using moments extracted from some sets of experimental data on $R(e^+e^- \rightarrow \mathrm{hadrons})$. This value for $a_{\mu}^c$ includes our determination of the effect of QED on this quantity, $\delta a_{\mu}^c = 0.0313(28) \times 10^{-10}$.Comment: Added extra discussion on QED setup, some new results to study the effects of strong isospin breaking in the sea (including new Fig. 1) and a fit stability plot for the hyperfine splitting (new Fig. 7). Version accepted for publication in PR

The pseudoscalar meson electromagnetic form factor at high Q2 from full lattice QCD

We give an accurate determination of the vector (electromagnetic) form factor, F(Q^2), for a light pseudoscalar meson up to squared momentum transfer Q^2 values of 6 GeV^2 for the first time from full lattice QCD, including u, d, s and c quarks in the sea at multiple values of the lattice spacing. Our results show good control of lattice discretisation and sea quark mass effects. We study a pseudoscalar meson made of valence s quarks but the qualitative picture obtained applies also to the \pi meson, relevant to upcoming experiments at Jefferson Lab. We find that Q^2F(Q^2) becomes flat in the region between Q^2 of 2 GeV^2 and 6 GeV^2, with a value well above that of the asymptotic perturbative QCD expectation, but well below that of the vector-meson dominance pole form appropriate to low Q^2 values. Our calculations show that we can reach higher Q^2 values in future to shed further light on where the perturbative QCD result emerges

B-meson decay constants: a more complete picture from full lattice QCD

We extend the picture of $B$-meson decay constants obtained in lattice QCD beyond those of the $B$, $B_s$ and $B_c$ to give the first full lattice QCD results for the $B^*$, $B^*_s$ and $B^*_c$. We use improved NonRelativistic QCD for the valence $b$ quark and the Highly Improved Staggered Quark (HISQ) action for the lighter quarks on gluon field configurations that include the effect of $u/d$, $s$ and $c$ quarks in the sea with $u/d$ quark masses going down to physical values. For the ratio of vector to pseudoscalar decay constants, we find $f_{B^*}/f_B$ = 0.941(26), $f_{B^*_s}/f_{B_s}$ = 0.953(23) (both $2\sigma$ less than 1.0) and $f_{B^*_c}/f_{B_c}$ = 0.988(27). Taking correlated uncertainties into account we see clear indications that the ratio increases as the mass of the lighter quark increases. We compare our results to those using the HISQ formalism for all quarks and find good agreement both on decay constant values when the heaviest quark is a $b$ and on the dependence on the mass of the heaviest quark in the region of the $b$. Finally, we give an overview plot of decay constants for gold-plated mesons, the most complete picture of these hadronic parameters to date.Comment: 20 pages, 9 figures. Minor updates to the discussion in several places and some additional reference

Lymph node but not intradermal injection site macrophages are critical for germinal center formation and antibody responses to rabies vaccination.

UNLABELLED: Replication-deficient rabies virus (RABV)-based vaccines induce rapid and potent antibody responses via T cell-independent and T cell-dependent mechanisms. To further investigate early events in vaccine-induced antibody responses against RABV infections, we studied the role of macrophages as mediators of RABV-based vaccine immunogenicity. In this report, we show that a recombinant matrix gene-deleted RABV-based vaccine (rRABV-ΔM) infects and activates primary murine macrophages in vitro. Immunization of mice with live RABV-based vaccines results in accumulation of macrophages at the site of immunization, which suggests that macrophages in tissues support the development of effective anti-RABV B cell responses. However, we show that draining lymph node macrophages, but not macrophages at the site of immunization, are essential for the generation of germinal center B cells, follicular T helper cells, and RABV-specific antibodies. Our findings have implications for the design of new RABV-based vaccines for which early immunological events are important for the protection against RABV in postexposure settings. IMPORTANCE: More than two-thirds of the world\u27s population live in regions where rabies is endemic. Postexposure prophylaxis is the primary means of treating humans. Identifying immunological principles that guide the development of rapid and potent antibody responses against rabies infections will greatly increase our ability to produce more-effective rabies vaccines. Here we report that macrophages in the draining lymph node, but not in the tissue at the site of immunization are important for vaccine-induced antibody responses to rabies. Information gleaned from this study may help guide the development of a single-dose vaccine against rabies infections

APRIL:TACI axis is dispensable for the immune response to rabies vaccination.

There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings. To accomplish this goal, rabies virus (RABV)-based vaccines must rapidly activate B cells to secrete antibodies which neutralize pathogenic RABV before it enters the CNS. Increased understanding of how B cells effectively respond to RABV-based vaccines may improve efforts to simplify post-exposure prophylaxis (PEP) regimens. Several studies have successfully employed the TNF family cytokine a proliferation-inducing ligand (APRIL) as a vaccine adjuvant. APRIL binds to the receptors TACI and B cell maturation antigen (BCMA)-expressed by B cells in various stages of maturation-with high affinity. We discovered that RABV-infected primary murine B cells upregulate APRIL ex vivo. Cytokines present at the time of antigen exposure affect the outcome of vaccination by influencing T and B cell activation and GC formation. Therefore, we hypothesized that the presence of APRIL at the time of RABV-based vaccine antigen exposure would support the generation of protective antibodies against RABV glycoprotein (G). In an effort to improve the response to RABV vaccination, we constructed and characterized a live recombinant RABV-based vaccine vector which expresses murine APRIL (rRABV-APRIL). Immunogenicity testing in mice demonstrated that expressing APRIL from the RABV genome does not impact the primary antibody response against RABV G compared to RABV alone. In order to evaluate the necessity of APRIL for the response to rabies vaccination, we compared the responses of APRIL-deficient and wild-type mice to immunization with rRABV. APRIL deficiency does not affect the primary antibody response to vaccination. Furthermore, APRIL expression by the vaccine did not improve the generation of long-lived antibody-secreting plasma cells (PCs) as serum antibody levels were equivalent in response to rRABV-APRIL and the vector eight weeks after immunization. Moreover, APRIL is dispensable for the long-lived antibody-secreting PC response to rRABV vaccination as anti-RABV G IgG levels were similar in APRIL-deficient and wild-type mice six months after vaccination. Mice lacking the APRIL receptor TACI demonstrated primary anti-RABV G antibody responses similar to wild-type mice following immunization with the vaccine vector indicating that this response is independent of TACI-mediated signals. Collectively, our findings demonstrate that APRIL and associated TACI signaling is dispensable for the immune response to RABV-based vaccination

About the parabolic relation existing between the skewness and the kurtosis in time series of experimental data

In this work we investigate the origin of the parabolic relation between skewness and kurtosis often encountered in the analysis of experimental time-series. We argue that the numerical values of the coefficients of the curve may provide informations about the specific physics of the system studied, whereas the analytical curve per se is a fairly general consequence of a few constraints expected to hold for most systems.Comment: To appear in Physica Script