Mucoepidermoid carcinoma associated with osteosarcoma in a true malignant mixed tumor of the submandibular region

True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements. Frequently carcinosarcoma arises in the background of a preexisting pleomorphic adenoma; however, if no evidence of benign mixed tumor is present, the lesion is known as carcinosarcoma "de novo." We reported the first case of true malignant mixed tumor of the submandibular gland composed of high grade mucoepidermoid carcinoma associated with osteosarcoma. Case Presentation. A 69-year-old Caucasian male came to our department complaining of the appearance of an asymptomatic left submandibular neoformation progressively increasing in size over 3 months. We opted for surgical treatment. Histological examination confirmed the diagnosis of carcinosarcoma with the coexistence of high grade mucoepidermoid carcinoma and osteosarcoma. Conclusion. To the best of our knowledge, in the true malignant mixed tumor of the submandibular gland, mucoepidermoid carcinoma associated with osteosarcoma has never been previously reported

Floor response spectra in RC frame structures designed according to Eurocode 8

© 2015 Springer Science+Business Media Dordrecht Nonstructural components (NSCs) should be subjected to a careful and rational seismic design, in order to reduce the economic loss and to avoid threats to the life safety, as well as what concerns structural elements. The design of NSCs is based on the evaluation of the maximum inertia force, which is related to the floor spectral accelerations. The question arises as to whether Eurocode 8 is able to predict actual floor response spectral accelerations occurring in structures designed according to Eurocode 8. A parametric study is conducted on five RC frame structures in order to evaluate the floor response spectra. The structures, designed according to Eurocode 8, are subjected to a set of earthquakes, compatible with the design response spectrum. Time-history analyses are performed both on elastic and inelastic models of the considered structures. Eurocode formulation for the evaluation of the seismic demand on NSCs does not well fit the numerical results. Some comments on the target spectrum provided by AC 156 for the seismic qualification of NSC are also included

The lesson learnt after Emilia-Romagna earthquakes on precast RC structures: a case-study

During Emilia-Romagna earthquakes (Northern Italy) on May 2012 a huge number of existing precast RC one-story buildings was severely damaged. Most of these structures were reinforced concrete one-story buildings, hosting industrial and commercial activities. The presented paper aims at simulating the structural behavior of an existing precast RC building, damaged during the Emilia-Romagna earthquakes. The direct inspection showed that the most serious damage was related to the connection systems: relative displacements between the beams and the columns; significant dislocations between the roof elements and the beams and some cases of loss of support of the roof elements. Moreover, large rotations were also recorded at the base of the columns. The presented study defines a reliable modeling approach and the dynamic analyses demonstrate the capability of the proposed model in simulating the real response of the structure. The results confirm that the most of the damage was caused by the second seismic event and the numerical evidences agree with the real recorded damage. The numerical outcomes demonstrate the significant influence of the vertical action on the connections behavior/failure

Olfactory evaluation in obstructive sleep apnoea patients

The sense of smell has a high impact on the quality of life. The aim of the present study was to investigate olfactory dysfunction in patients with obstructive sleep apnoea syndrome (OSAS) and correlate the severity of disease with olfactory dysfunction. The relationships between nasal obstruction, nasal mucociliary cleareance and olfactory tests were also evaluated. Sixty patients with a diagnosis of OSAS were enrolled and underwent olfactory function evaluation. In all patients olfactory performance was tested with the Sniffin’ Sticks method. Mucociliary transport times and anterior rhinomanometry were performed to identify eventual nasal obstruction and deficits in nasal mucociliary clearance. Olfactory dysfunction was present in 22 (36.6%) patients of the study group: of these, hyposmia was present in 19 (86.4%) and anosmia in 3 (13.6%). The mean TDI score in the study group was 30. A strong correlation between the olfactory dysfunction and severity of sleep apnoea measured using the AHI was found. Patients with OSA would seem to have a high incidence of olfactory dysfunction. The degree of olfactory dysfunction appears to be related to the severity of disease. However, other co-factors such as nasal obstruction and reduced mucociliary clearance might also play a role in of the aetiology of this condition

Cyclic shear tests on RC precast beam-to-column connections retrofitted with a three-hinged steel device

Recent European earthquakes demonstrated that the seismic response of RC precast structures can be significantly influenced by the connection systems. Moreover, during past seismic events, many failures of the beam-to-column connections occurred due to their inadequate strength under seismic loads. The seismic safety of these connections has a crucial role in the overall seismic capacity of existing precast structures. A new connection system is employed as a retrofitting solution for a damaged beam-to-column connection and its cyclic shear performance is investigated by means of two cyclic shear tests on two different configurations. In both the experimental tests, the results demonstrate an efficient behavior of the retrofitted connections under horizontal cyclic loads. The comparison between the performance of the investigated connection and the response of a typical beam-to-column dowel connection allows to discuss the main critical features of the dowel connection system

Long-term subjective outcomes of barbed reposition pharyngoplasty for obstructive sleep apnea syndrome treatment

Background: The purpose of this study was to evaluate long-term subjective outcomes of barbed reposition pharyngoplasty for obstructive sleep apnea syndrome (OSAS) treatment using a specific questionnaire, the Palate Postoperative Problem Score (PPOPS). Methods: 140 patients who underwent barbed reposition pharyngoplasty (BRP) surgery in the Morgagni Pierantoni Hospital of Forlì, Italy were enrolled in the study. Postoperative outcomes were evaluated in a short- and long-term follow-up using the PPOPS questionnaire. The average period of follow-up was 26 months. All patients received the PPOPS questionnaire by telephone in a period between April and August 2019. Results: 51% of patients complained of swallowing problems after surgery. In 91% of cases, the problem cleared up spontaneously. At the time of the interview, only 9% of patients had a residual swallowing difficult. At the time of PPOPS evaluation, rhinolalia was observed in 8% of patients, whereas nose regurgitation was present in 2% of patients. In 20% of patients, the foreign body sensation was present during follow-up. The value of apnea-hypopnea index (AHI) reduced from the preoperative value of 31.5 to the postoperative value of 11.4. Conclusions: BRP surgery proved to be an effective technique, appreciated by the majority of patients. Use of the PPOPS questionnaire has demonstrated that the BRP technique seems to ensure efficacy and lower morbidity, with few complications after surgery

On the seismic design of one-story precast structures for P-Δ effects

P-Δ effects can reduce the seismic safety of structures under seismic actions and they can be vital for one-story precast buildings because of the large flexibility of columns. According to European building code, P-Δ effects can be taken into account by following some design requirements. Such requirements can significantly influence the design of the structures since they may provide the amplification of the seismic demand by means of the stability factor as well as the oversizing of the elements. This study investigates the influence of P-Δ effects on the seismic performance of precast one-story structures. An extensive parametric study is performed on one-story precast structures by varying some geometric features of the structure and the seismicity level of the site. Nonlinear dynamic analyses are performed by using Newmark’s method on all the case studies and the results of the first order and second order analysis are compared and discussed. Moreover, different design approaches are adopted in order to assess the Eurocode provisions for P-Δ effects. The results of the nonlinear dynamic analyses demonstrate that the overstrength, due to seismic detailing of columns and the materials overstrength, induces very low ductility demand for the structures. Indeed, even if P-Δ effects are totally neglected in the design phase, the overstrength due to other code prescriptions (e.g. minimum longitudinal reinforcement ratio) can still induce low ductility demand. Moreover it is demonstrated that the code prescriptions on P-Δ effects do not generally increase the structural safety and an alternative design approach is proposed, which gives both safer and cheaper structures than the ones currently designed according to Eurocodes

Risk factors for obstructive sleep apnea syndrome in children: state of the art

The obstructive sleep apnea syndrome (OSAS) represents only part of a large group of pathologies of variable entity called respiratory sleep disorders (RSD) which include simple snoring and increased upper airway resistance syndrome (UARS). Although the etiopathogenesis of adult OSAS is well known, many aspects of this syndrome in children are still debated. Its prevalence is about 2% in children from 2 to 8 years of age, mostly related to the size of the upper airways adenoid tissue. Several risk factors linked to the development of OSAS are typical of the pediatric age. The object of this paper is to analyze the state of the art on this specific topic, discussing its implications in terms of diagnosis and management

Shake table tests for the seismic fragility evaluation of hospital rooms

© 2014 John Wiley & Sons, Ltd. Health care facilities may undergo severe and widespread damage that impairs the functionality of the system when it is stricken by an earthquake. Such detrimental response is emphasized either for the hospital buildings designed primarily for gravity loads or without employing base isolation/supplemental damping systems. Moreover, these buildings need to warrant operability especially in the aftermath of moderate-to-severe earthquake ground motions. The provisions implemented in the new seismic codes allow obtaining adequate seismic performance for the hospital structural components; nevertheless, they do not provide definite yet reliable rules to design and protect the building contents. To date, very few experimental tests have been carried out on hospital buildings equipped with nonstructural components as well as building contents. The present paper is aimed at establishing the limit states for a typical health care room and deriving empirical fragility curves by considering a systemic approach. Toward this aim, a full scale three-dimensional model of an examination (out patients consultation) room is constructed and tested dynamically by using the shaking table facility of the University of Naples, Italy. The sample room contains a number of typical medical components, which are either directly connected to the panel boards of the perimeter walls or behave as simple freestanding elements. The outcomes of the comprehensive shaking table tests carried out on the examination room have been utilized to derive fragility curves based on a systemic approach