483 research outputs found

    Bose glass behavior in (Yb1x_{1-x}Lux_x)4_4As3_3 representing the randomly diluted quantum spin-1/2 chains

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    The site-diluted compound (Yb1x_{1-x}Lux_x)4_4As3_3 is a scarce realization of the linear Heisenberg antiferromagnet partitioned into finite-size segments and is an ideal model compound for studying field-dependent effects of quenched disorder in the one-dimensional antiferromagnets. It differentiates from the systems studied so far in two aspects - the type of randomness and the nature of the energy gap in the pure sample. We have measured the specific heat of single-crystal (Yb1x_{1-x}Lux_x)4_4As3_3 in magnetic fields up to 19.5 T. The contribution CC_{\perp} arising from the magnetic subsystem in an applied magnetic field perpendicular to the chains is determined. Compared to pure Yb4_4As3_3, for which CC_{\perp} indicates a gap opening, for diluted systems a non-exponential decay is found at low temperatures which is consistent with the thermodynamic scaling of the specific heat established for a Bose-glass phase.Comment: 8 pages, 17 figures, including supplemental material, accepted for PRB rapid communicatio

    Field-dependent specific heat of Yb4As3: agreement between a spin-1/2 model and experiment

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    We report the low-temperature specific-heat measurements on polydomain Yb4As3 at magnetic fields up to 20 T. Taking into account the Bethe ansatz results, the zero-field data have been used for the estimation of the lattice specific heat, resulting in a value of the exchange integral for the Heisenberg model of the antiferromagnetic spin S=1/2 chain of J/k(B)=-28 K. A quantitative agreement has been achieved between the experimental magnetic specific-heat data in magnetic field and the numerical results obtained by the quantum transfer-matrix (QTM) simulation technique. The finite-size QTM approximants have been analyzed and an extrapolation procedure recovering the known density matrix renormalization group (DMRG) results down to very low temperature has been proposed. On the basis of the data in magnetic field and using the earlier DMRG results, the energy-gap size Delta has been analyzed as a function of the applied magnetic field B, leading to an experimental verification of the scaling law Delta alpha B-2/3 following from the sine-Gordon model.Polish Ministry of Science and High Education [N202 309835

    Changes in Employment Uncertainty and the Fertility Intention-Realization Link: An Analysis Based on the Swiss Household Panel.

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    How do changes in employment uncertainty matter for fertility? Empirical studies on the impact of employment uncertainty on reproductive decision-making offer a variety of conclusions, ranging from gender and socio-economic differences in the effect of employment uncertainty on fertility intentions and behaviour, to the effect of employment on changes in fertility intentions. This article analyses the association between a change in subjective employment uncertainty and fertility intentions and behaviour by distinguishing male and female partners' employment uncertainty, and examines the variation in these associations by education. Using a sample of men and women living in a couple from the Swiss Household Panel (SHP 2002-2011), we examine through multinomial analysis how changes in employment uncertainty and selected socio-demographic factors are related to individual childbearing decisions. Our results show strong gendered effects of changes in employment uncertainty on the revision of reproductive decisions among the highly educated population

    Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis

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    Background: Multiple sclerosis is a widespread inflammatory demyelinating disease. Several immunomodulatory therapies are available, including interferon-β, glatiramer acetate, natalizumab, fingolimod, and mitoxantrone. Although useful to delay disease progression, they do not provide a definitive cure and are associated with some undesirable side-effects. Accordingly, the search for new therapeutic methods constitutes an active investigation field. The use of mesenchymal stem cells (MSCs) to modify the disease course is currently the subject of intense interest. Decidua-derived MSCs (DMSCs) are a cell population obtained from human placental extraembryonic membranes able to differentiate into the three germ layers. This study explores the therapeutic potential of DMSCs. Methods: We used the experimental autoimmune encephalomyelitis (EAE) animal model to evaluate the effect of DMSCs on clinical signs of the disease and on the presence of inflammatory infiltrates in the central nervous system. We also compared the inflammatory profile of spleen T cells from DMSC-treated mice with that of EAE control animals, and the influence of DMSCs on the in vitro definition of the Th17 phenotype. Furthermore, we analyzed the effects on the presence of some critical cell types in central nervous system infiltrates. Results: Preventive intraperitoneal injection of DMSCs resulted in a significant delay of external signs of EAE. In addition, treatment of animals already presenting with moderate symptoms resulted in mild EAE with reduced disease scores. Besides decreased inflammatory infiltration, diminished percentages of CD4+IL17+, CD11b+Ly6G+ and CD11b+Ly6C+ cells were found in infiltrates of treated animals. Early immune response was mitigated, with spleen cells of DMSC-treated mice displaying low proliferative response to antigen, decreased production of interleukin (IL)-17, and increased production of the anti-inflammatory cytokines IL-4 and IL-10. Moreover, lower RORγT and higher GATA-3 expression levels were detected in DMSC-treated mice. DMSCs also showed a detrimental influence on the in vitro definition of the Th17 phenotype. Conclusions: DMSCs modulated the clinical course of EAE, modified the frequency and cell composition of the central nervous system infiltrates during the disease, and mediated an impairment of Th17 phenotype establishment in favor of the Th2 subtype. These results suggest that DMSCs might provide a new cell-based therapy for the control of multiple sclerosis.This work was sponsored by grants from Acción Estratégica en Salud (PI13/00297 and PI11/00581), the Neurosciences and Aging Foundation, the Francisco Soria Melguizo Foundation, Octopharma, and Parkinson Madrid (PI2012/0032).S

    The scope of application of incremental rapid prototyping methods in foundry engineering

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    Abstract The article presents the scope of application of selected incremental Rapid Prototyping methods in the process of manufacturing casting models, casting moulds and casts. The Rapid Prototyping methods (SL, SLA, FDM, 3DP, JS) are predominantly used for the production of models and model sets for casting moulds. The Rapid Tooling methods, such as: ZCast-3DP, ProMetalRCT and VoxelJet, enable the fabrication of casting moulds in the incremental process. The application of the RP methods in cast production makes it possible to speed up the prototype preparation process. This is particularly vital to elements of complex shapes. The time required for the manufacture of the model, the mould and the cast proper may vary from a few to several dozen hours
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