An Extension of Generalized Linear Models to Finite Mixture Outcome Distributions

Finite mixture distributions arise in sampling a heterogeneous population. Data drawn from such a population will exhibit extra variability relative to any single subpopulation. Statistical models based on finite mixtures can assist in the analysis of categorical and count outcomes when standard generalized linear models (GLMs) cannot adequately account for variability observed in the data. We propose an extension of GLM where the response is assumed to follow a finite mixture distribution, while the regression of interest is linked to the mixture's mean. This approach may be preferred over a finite mixture of regressions when the population mean is the quantity of interest; here, only a single regression function must be specified and interpreted in the analysis. A technical challenge is that the mean of a finite mixture is a composite parameter which does not appear explicitly in the density. The proposed model is completely likelihood-based and maintains the link to the regression through a certain random effects structure. We consider typical GLM cases where means are either real-valued, constrained to be positive, or constrained to be on the unit interval. The resulting model is applied to two example datasets through a Bayesian analysis: one with success/failure outcomes and one with count outcomes. Supporting the extra variation is seen to improve residual plots and to appropriately widen prediction intervals

Modification of nuclear transitions in stellar plasma by electronic processes: K-isomers in 176Lu and 180Ta under s-process conditions

The influence of the stellar plasma on the production and destruction of K-isomers is studied for the examples 176Lu and 180Ta. Individual electromagnetic transitions are enhanced predominantly by nuclear excitation by electron capture, whereas the other mechanisms of electron scattering and nuclear excitation by electron transition give only minor contributions. It is found that individual transitions can be enhanced significantly for low transition energies below 100 keV. Transitions with higher energies above 200 keV are practically not affected. Although one low-energy transition in 180Ta is enhanced by up to a factor of 10, the stellar transition rates from low-K to high-K states via so-called intermediate states in 176Lu and 180Ta do not change significantly under s-process conditions. The s-process nucleosynthesis of 176Lu and 180Ta remains essentially unchanged.Comment: 10 pages, 10 figures, Phys. Rev. C, accepte

Light elements in massive single and binary stars

We highlight the role of the light elements (Li, Be, B) in the evolution of massive single and binary stars, which is largely restricted to a diagnostic value, and foremost so for the element boron. However, we show that the boron surface abundance in massive early type stars contains key information about their foregoing evolution which is not obtainable otherwise. In particular, it allows to constrain internal mixing processes and potential previous mass transfer event for binary stars (even if the companion has disappeared). It may also help solving the mystery of the slowly rotating nitrogen-rich massive main sequence stars.Comment: 10 pages, 8 figures, to appear in proc. IAU-Symp. 268. C. Charbonnel et al., eds

Asteroseismology and calibration of alpha Cen binary system

Using the oscillation frequencies of alpha Cen A recently discovered by Bouchy & Carrier, the available astrometric, photometric and spectroscopic data, we tried to improve the calibration of the visual binary system alpha Cen. With the revisited masses of Pourbaix et al. (2002) we do not succeed to obtain a solution satisfying all the seismic observational constraints. Relaxing the constraints on the masses, we have found an age t_alpha Cen=4850+-500 Myr, an initial helium mass fraction Y_i = 0.300+-0.008, and an initial metallicity (Z/X)_i=0.0459+-0.0019, with M_A=1.100+-0.006M_o and M_B=0.907+-0.006M_o for alpha Cen A&B.Comment: accepted for publication as a letter in A&

Evidence for Integrin – Venus Kinase Receptor 1 Alliance in the Ovary of Schistosoma mansoni Females Controlling Cell Survival

Parasites of the genus Schistosoma cause schistosomiasis, a life-threatening infectious disease for humans and animals worldwide. Among the remarkable biological features of schistosomes is the differentiation of the female gonads which is controlled by pairing with the male and a prerequisite for egg production. Eggs, however, are not only important for the maintenance of the life-cycle; they also cause the pathological consequences of schistosomiasis. Part of the eggs gets trapped in host tissues such as liver and spleen and trigger inflammatory processes, finally leading to liver cirrhosis. Research activities of the last decade have indicated that different families of cellular and receptor-type kinases but also integrins contribute to the control of mitogenic activity and differentiation the female goands. In this context an unusual class of receptor tyrosine kinases (RTKs) has been identified, the venus kinase receptors (SmVKRs). By biochemical and molecular approaches we demonstrate that SmVKR1 activation can be achieved by cooperation with a signaling complex consisting of the beta integrin receptor Smß-Int1 and the bridging molecules SmILK, SmPINCH, SmNck2. Besides unravelling a novel way of SmVKR1 activation, we provide evidence that this complex controls the differentiation status of oocytes by regulating cell death-associated processes

Morphogenetic analysis of the phenotypic variability of the architectural unit of Hydrangea macrophylla

Hydrangea macrophylla is a ligneous plant that has attracted the attention of many plant breeders and agronomists for the purpose of enhancing its phenotypic plasticity. However, this plasticity was always exploited empirically.Can this plasticity be assessed by a more scientific approach? In this work, the phenotypic variation is analysed via a description of the different development sequences of the plant and by exposing the plant to different contrasted environments. The architectural unit consists of two morphogenetic units: the Vegetative Unit (VU) and the Vegetative and Floral Unit (VFU). They result in four successive development sequences: an organogenetic phase accompanied by continuous growth (sequence A), floral transformation (sequence B), dormancy (sequence C) and flower bloom (sequence D). Under the effect of environmental factors, the formation of the mixed terminal bud (sequence B) provides a considerable source of spatial variability, whereas the absence or presence of dormancy (sequence C) is responsible for a source of temporal variation. The in-depth description of the architectural unit with its morphological components and the characterisation of the four development sequences provide a necessary scientific basis to identify environmental effects on plant development and for the integrated use of its plasticity

Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats

Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation. Maternal toxicity, evidenced by decreased in body weight gain and food consumption, tended to be greater after simultaneous exposures to the high concentrations of 1000 ppm EB and 3000 ppm MEK, when compared to the treatments with individual compounds. No significant increase in embryo/fetal lethality or incidence of malformations and variations was observed in any of the treatment groups. Fetal body weight was significantly reduced after individual treatment with 1000 ppm EB or 3000 ppm MEK, and in the combined groups. There was no evidence of interaction between EB and MEK in causing developmental toxicity