Social Media and Small Entrepreneurial Firms’ Internationalization

AbstractSmall entrepreneurial firms often need to be quite creative when allocating and deploying their limited resources. Especially in grasping international opportunities, social media provides a seemingly affordable and far-reaching medium. However, challenges—such as the controllability of the content and the outcomes of using social media—become apparent as the reach of social media marketing expands beyond certain threshold limits. In this study, we rely on data from multiple case studies to evaluate to what extent and under which conditions social media can support small entrepreneurial firms’ international expansion. Thereby, we contribute to research on SME internationalization and business implications of digitalization. Our findings indicate that small entrepreneurial firms face somewhat different social media–related challenges in the international business environment compared to domestic settings. The controllability of the contents comes with new tones. Furthermore, small firms’ resources, both in terms of social media use and in different functions, play an important role in determining the extent to which the use of social media supports these firms’ internationalization.Abstract Small entrepreneurial firms often need to be quite creative when allocating and deploying their limited resources. Especially in grasping international opportunities, social media provides a seemingly affordable and far-reaching medium. However, challenges—such as the controllability of the content and the outcomes of using social media—become apparent as the reach of social media marketing expands beyond certain threshold limits. In this study, we rely on data from multiple case studies to evaluate to what extent and under which conditions social media can support small entrepreneurial firms’ international expansion. Thereby, we contribute to research on SME internationalization and business implications of digitalization. Our findings indicate that small entrepreneurial firms face somewhat different social media–related challenges in the international business environment compared to domestic settings. The controllability of the contents comes with new tones. Furthermore, small firms’ resources, both in terms of social media use and in different functions, play an important role in determining the extent to which the use of social media supports these firms’ internationalization

The Atypical Calpains: Evolutionary Analyses and Roles in Caenorhabditis elegans Cellular Degeneration

The calpains are physiologically important Ca2+-activated regulatory proteases, which are divided into typical or atypical sub-families based on constituent domains. Both sub-families are present in mammals, but our understanding of calpain function is based primarily on typical sub-family members. Here, we take advantage of the model organism Caenorhabditis elegans, which expresses only atypical calpains, to extend our knowledge of the phylogenetic evolution and function of calpains. We provide evidence that a typical human calpain protein with a penta EF hand, detected using custom profile hidden Markov models, is conserved in ancient metazoans and a divergent clade. These analyses also provide evidence for the lineage-specific loss of typical calpain genes in C. elegans and Ciona, and they reveal that many calpain-like genes lack an intact catalytic triad. Given the association between the dysregulation of typical calpains and human degenerative pathologies, we explored the phenotypes, expression profiles, and consequences of inappropriate reduction or activation of C. elegans atypical calpains. These studies show that the atypical calpain gene, clp-1, contributes to muscle degeneration and reveal that clp-1 activity is sensitive to genetic manipulation of [Ca2+]i. We show that CLP-1 localizes to sarcomeric sub-structures, but is excluded from dense bodies (Z-disks). We find that the muscle degeneration observed in a C. elegans model of dystrophin-based muscular dystrophy can be suppressed by clp-1 inactivation and that nemadipine-A inhibition of the EGL-19 calcium channel reveals that Ca2+ dysfunction underlies the C. elegans MyoD model of myopathy. Taken together, our analyses highlight the roles of calcium dysregulation and CLP-1 in muscle myopathies and suggest that the atypical calpains could retain conserved roles in myofilament turnover

Semantic Indexing Of Multimedia Using Audio, Text And Visual Cues

In this paper we describe methods for automatic labeling of highlevel semantic concepts in documentary style videos. The emphasis of this paper is on audio processing and on fusing information from multiple modalities. The work described represents initial work towards a trainable system that acquires a collection of generic "intermediate" semantic concepts across modalities (such as audio, video, text) and combines information from these modalities for automatic labeling of a "high-level" concept. Initial results suggest that multi-modal fusion achieves a 12.5% relative improvement over the best unimodal model