Nucleosynthesis in Type I X-ray Bursts

Type I X-ray bursts are thermonuclear explosions that occur in the envelopes of accreting neutron stars. Detailed observations of these phenomena have prompted numerous studies in theoretical astrophysics and experimental nuclear physics since their discovery over 35 years ago. In this review, we begin by discussing key observational features of these phenomena that may be sensitive to the particular patterns of nucleosynthesis from the associated thermonuclear burning. We then summarize efforts to model type I X-ray bursts, with emphasis on determining the nuclear physics processes involved throughout these bursts. We discuss and evaluate limitations in the models, particularly with regard to key uncertainties in the nuclear physics input. Finally, we examine recent, relevant experimental measurements and outline future prospects to improve our understanding of these unique environments from observational, theoretical and experimental perspectives.Comment: Accepted by Prog. Part. Nucl. Phys., 45 pages, 14 figure

Classical novae and type I X-ray bursts: challenges for the 21st century

Classical nova explosions and type I X-ray bursts are the most frequent types of thermonuclear stellar explosions in the Galaxy. Both phenomena arise from thermonuclear ignition in the envelopes of accreting compact objects in close binary star systems. Detailed observations of these events have stimulated numerous studies in theoretical astrophysics and experimental nuclear physics. We discuss observational features of these phenomena and theoretical efforts to better understand the energy production and nucleosynthesis in these explosions. We also examine and summarize studies directed at identifying nuclear physics quantities with uncertainties that significantly affect model predictions.Comment: 40 pages, accepted for AIP Advances: Stardust - Progress and Problems in Nuclear Astrophysic

Dynamic behavior of an unsteady trubulent boundary layer

Experiments on an unsteady turbulent boundary layer are reported in which the upstream portion of the flow is steady (in the mean) and in the downstream region, the boundary layer sees a linearly decreasing free stream velocity. This velocity gradient oscillates in time, at frequencies ranging from zero to approximately the bursting frequency. For the small amplitude, the mean velocity and mean turbulence intensity profiles are unaffected by the oscillations. The amplitude of the periodic velocity component, although as much as 70% greater than that in the free stream for very low frequencies, becomes equal to that in the free stream at higher frequencies. At high frequencies, both the boundary layer thickness and the Reynolds stress distribution across the boundary layer become frozen. The behavior at higher amplitude is quite similar. At sufficiently high frequencies, the boundary layer thickness remains frozen at the mean value over the oscillation cycle, even though flow reverses near the wall during a part of the cycle

Application of laminar flow control to supersonic transport configurations

The feasibility and impact of implementing a laminar flow control system on a supersonic transport configuration were investigated. A hybrid laminar flow control scheme consisting of suction controlled and natural laminar flow was developed for a double-delta type wing planform. The required suction flow rates were determined from boundary layer stability analyses using representative wing pressure distributions. A preliminary design of structural modifications needed to accommodate suction through a perforated titanium skin was carried out together with the ducting and systems needed to collect, compress and discharge the suction air. The benefits of reduced aerodynamic drag were weighed against the weight, volume and power requirement penalties of suction system installation in a mission performance and sizing program to assess the net benefits. The study showed a feasibility of achieving significant laminarization of the wing surface by use of a hybrid scheme, leading to an 8.2 percent reduction in the cruise drag. This resulted in an 8.5 percent reduction in the maximum takeoff weight and a 12 percent reduction in the fuel burn after the inclusion of the LFC system installation penalties. Several research needs were identified for a resolution of aerodynamics, structural and systems issues before these potential benefits could be realized in a practical system

Hawking Radiation as Tunneling

We present a short and direct derivation of Hawking radiation as a tunneling process, based on particles in a dynamical geometry. The imaginary part of the action for the classically forbidden process is related to the Boltzmann factor for emission at the Hawking temperature. Because the derivation respects conservation laws, the exact spectrum is not precisely thermal. We compare and contrast the problem of spontaneous emission of charged particles from a charged conductor.Comment: LaTeX, 10 pages; v2. journal version, added section on relation of black hole radiation to electric charge emission from a charged conducting sphere; v3. restored cut referenc

Particle decay branching ratios for states of astrophysical importance in 19Ne

We have measured proton and alpha-particle branching ratios of excited states in 19Ne formed using the 19F(3He,t) reaction at a beam energy of 25 MeV. These ratios have a large impact on the astrophysical reaction rates of 15O(alpha,gamma), 18F(p,gamma) and 18F(p,alpha), which are of interest in understanding energy generation in x-ray bursts and in interpreting anticipated gamma-ray observations of novae. We detect decay protons and alpha-particles using a silicon detector array in coincidence with tritons measured in the focal plane detector of our Enge split-pole spectrograph. The silicon array consists of five strip detectors of the type used in the Louvain-Edinburgh Detector Array, subtending angles from 130 degrees to 165 degrees with approximately 14% lab efficiency. The correlation angular distributions give additional confidence in some prior spin-parity assignments that were based on gamma branchings. We measure Gamma_p/Gamma=0.387+-0.016 for the 665 keV proton resonance, which agrees well with the direct measurement of Bardayan et al.Comment: 5 pages, 2 figures, 3 tables. Prepared using RevTex 4 and BibTex. Further minor revisions, incl. fig. 1 font size increase, 1 table removal, and minor changes to the tex

Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study.

IntroductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury. In persons with reduced estimated glomerular filtration rate (eGFR) and albuminuria who are at high risk for end-stage renal disease (ESRD) and death, the associations of these urinary markers with incident ESRD or death is an area of active investigation.MethodsAmong 1472 black and white participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study with eGFR ≤60 ml/min per 1.73 m2 (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] cystatin, 2012) and albumin-to-creatinine ratio (ACR) ≥30 mg/g, we evaluated the associations of baseline uNGAL and uKIM-1 with progression to ESRD and all-cause death. Cox models were sequentially adjusted for urinary creatinine, traditional risk factors, C-reactive protein, ACR, and eGFR.ResultsThere were 257 ESRD events and 819 deaths over a median follow-up of 5.7 and 6.5 years, respectively. In demographic adjusted models, higher levels of uNGAL were associated with increased risk of ESRD and death, but these associations were attenuated in fully adjusted models including baseline eGFR for both ESRD (hazard ratio [HR] = 1.06 per doubling, 95% confidence interval [CI] 0.98-1.14) and death (HR = 1.04, 95% CI = 1.00-1.08). Higher levels of uKIM-1 were associated with increased risk of ESRD and death in demographic-adjusted models, and although attenuated in fully adjusted models, remained statistically significant for both ESRD (HR = 1.24 per doubling, 95% CI = 1.08-1.42) and death (HR = 1.10, 95% CI =1.03-1.19).ConclusionIn this cohort of high-risk patients with baseline eGFR ≤60 ml/min per 1.73 m2 and albuminuria, renal tubular injury is associated with higher mortality and progression to ESRD. Further studies are necessary to investigate the mechanism underlying this increased risk

Treatment utilization and outcomes in elderly patients with locally advanced esophageal carcinoma: A review of the National Cancer Database

For elderly patients with locally advanced esophageal cancer, therapeutic approaches and outcomes in a modern cohort are not well characterized. Patients ≥70 years old with clinical stage II and III esophageal cancer diagnosed between 1998 and 2012 were identified from the National Cancer Database and stratified based on treatment type. Variables associated with treatment utilization were evaluated using logistic regression and survival evaluated using Cox proportional hazards analysis. Propensity matching (1:1) was performed to help account for selection bias. A total of 21,593 patients were identified. Median and maximum ages were 77 and 90, respectively. Treatment included palliative therapy (24.3%), chemoradiation (37.1%), trimodality therapy (10.0%), esophagectomy alone (5.6%), or no therapy (12.9%). Age ≥80 (OR 0.73), female gender (OR 0.81), Charlson-Deyo comorbidity score ≥2 (OR 0.82), and high-volume centers (OR 0.83) were associated with a decreased likelihood of palliative therapy versus no treatment. Age ≥80 (OR 0.79) and Clinical Stage III (OR 0.33) were associated with a decreased likelihood, while adenocarcinoma histology (OR 1.33) and nonacademic cancer centers (OR 3.9), an increased likelihood of esophagectomy alone compared to definitive chemoradiation. Age ≥80 (OR 0.15), female gender (OR 0.80), and non-Caucasian race (OR 0.63) were associated with a decreased likelihood, while adenocarcinoma histology (OR 2.10) and high-volume centers (OR 2.34), an increased likelihood of trimodality therapy compared to definitive chemoradiation. Each treatment type demonstrated improved survival compared to no therapy: palliative treatment (HR 0.49) to trimodality therapy (HR 0.25) with significance between all groups. Any therapy, including palliative care, was associated with improved survival; however, subsets of elderly patients with locally advanced esophageal cancer are less likely to receive aggressive therapy. Care should be taken to not unnecessarily deprive these individuals of treatment that may improve survival

PAR1 Agonists Stimulate APC-Like Endothelial Cytoprotection and Confer Resistance to Thromboinflammatory Injury

Stimulation of protease-activated receptor 1 (PAR1) on endothelium by activated protein C (APC) is protective in several animal models of disease, and APC has been used clinically in severe sepsis and wound healing. Clinical use of APC, however, is limited by its immunogenicity and its anticoagulant activity. We show that a class of small molecules termed “parmodulins” that act at the cytosolic face of PAR1 stimulates APC-like cytoprotective signaling in endothelium. Parmodulins block thrombin generation in response to inflammatory mediators and inhibit platelet accumulation on endothelium cultured under flow. Evaluation of the antithrombotic mechanism showed that parmodulins induce cytoprotective signaling through Gβγ, activating a PI3K/Akt pathway and eliciting a genetic program that includes suppression of NF-κB–mediated transcriptional activation and up-regulation of select cytoprotective transcripts. STC1 is among the up-regulated transcripts, and knockdown of stanniocalin-1 blocks the protective effects of both parmodulins and APC. Induction of this signaling pathway in vivo protects against thromboinflammatory injury in blood vessels. Small-molecule activation of endothelial cytoprotection through PAR1 represents an approach for treatment of thromboinflammatory disease and provides proof-of-principle for the strategy of targeting the cytoplasmic surface of GPCRs to achieve pathway selective signaling

Quantum fields in gravity

We give a brief description of some compelling connections between general relativity and thermodynamics through i) the semi-classical tunnelling method(s) and ii) the field-theoretical modelling of Unruh-DeWitt detectors. In both approaches it is possible to interpret some quantities in a thermodynamical frame.Comment: 4 pages, no figures, contribution to the proceedings of the conference "Relativity and Gravitation - 100 years after Einstein in Prague