A Search for Nitrogen Enriched Quasars in the Sloan Digital Sky Survey Early Data Release

A search for nitrogen-rich quasars in the Sloan Digital Sky Survey Early Data Release (SDSS EDR) catalog has yielded 16 candidates, including five with very prominent emission, but no cases with nitrogen emission as strong as in Q0353-383. The quasar Q0353-383 has long been known to have extremely strong nitrogen intercombination lines at lambda 1486 and lambda 1750 Angstroms, implying an anomalously high nitrogen abundance of about 15 times solar. It is still the only one of its kind known. A preliminary search through the EDR using the observed property of the weak C IV emission seen in Q0353-383 resulted in a sample of 23 objects with unusual emission or absorption-line properties, including one very luminous redshift 2.5 star-forming galaxy. We present descriptions, preliminary emission-line measurements, and spectra for all the objects discussed here.Comment: 20 pages, 5 figures, submitted to AJ; final refereed versio

Quantitative Morphology of Galaxies in the Hubble Deep Field

We measure quantitative structural parameters of galaxies in the Hubble Deep Field (HDF) on the drizzled F814W images. Our structural parameters are based on a two-component surface brightness made up of a S\'ersic profile and an exponential profile. We compare our results to the visual classification of van den Bergh et al. (1996) and the $C-A$ classification of Abraham et al. (1996a). Our morphological analysis of the galaxies in the HDF indicates that the spheroidal galaxies, defined here as galaxies with a dominant bulge profile, make up for only a small fraction, namely 8% of the galaxy population down to m$_{F814W}(AB)$ = 26.0. We show that the larger fraction of early-type systems in the van den Bergh sample is primarily due to the difference in classification of 40% of small round galaxies with half-light radii < 0\arcsecpoint 31. Although these objects are visually classified as elliptical galaxies, we find that they are disk-dominated with bulge fractions < 0.5. Given the existing large dataset of HDF galaxies with measured spectroscopic redshifts, we are able to determine that the majority of distant galaxies ($z>2$) from this sample are disk-dominated. Our analysis reveals a subset of HDF galaxies which have profiles flatter than a pure exponential profile.Comment: 35 pages, LaTeX, 18 Postscript Figures, Tables available at http://astro.berkeley.edu/~marleau/. Accepted for Publication in The Astrophysical Journa

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury.

Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the safety and efficacy of intravenous (IV) glyburide. Twenty-eight subjects were randomized and underwent a 72-h infusion of IV glyburide or placebo, beginning within 10 h of trauma. Of the 28 subjects, 25 had Glasgow Coma Scale (GCS) scores of 6-10, and 14 had contusions. There were no differences in adverse events (AEs) or severe adverse events (ASEs) between groups. The magnetic resonance imaging (MRI) percent change at 72-168 h from screening/baseline was compared between the glyburide and placebo groups. Analysis of contusions (7 per group) showed that lesion volumes (hemorrhage plus edema) increased 1036% with placebo versus 136% with glyburide (p = 0.15), and that hemorrhage volumes increased 11.6% with placebo but decreased 29.6% with glyburide (p = 0.62). Three diffusion MRI measures of edema were quantified: mean diffusivity (MD), free water (FW), and tissue MD (MDt), corresponding to overall, extracellular, and intracellular water, respectively. The percent change with time for each measure was compared in lesions (n = 14) versus uninjured white matter (n = 24) in subjects receiving placebo (n = 20) or glyburide (n = 18). For placebo, the percent change in lesions for all three measures was significantly different compared with uninjured white matter (analysis of variance [ANOVA], p &lt; 0.02), consistent with worsening of edema in untreated contusions. In contrast, for glyburide, the percent change in lesions for all three measures was not significantly different compared with uninjured white matter. Further study of IV glyburide in contusion TBI is warranted

Constraints On the Size Evolution of Brightest Cluster Galaxies

We measure the luminosity profiles of 16 brightest cluster galaxies (BCGs) at $0.4 < z < 0.8$ using high resolution F160W NICMOS and F814W WFPC2 HST imaging. The heterogeneous sample is drawn from a variety of surveys: seven from clusters in the Einstein Medium Sensitivity Survey, five from the Las Campanas Distant Cluster Survey and its northern hemisphere precursor, and the remaining four from traditional optical surveys. We find that the surface brightness profiles of all but three of these BCGs are well described by a standard de Vaucouleurs ($r^{1/4}$) profile out to at least $\sim2r_{e}$ and that the biweight-estimated NICMOS effective radius of our high redshift BCGs ($r_{e} = 8.3\pm 1.4$ kpc for $H_{0} = 80$ km s$^{-1}$ Mpc$^{-1}$, $\Omega_{m} = 0.2, \Omega_\Lambda = 0.0$) is $\sim 2$ times smaller than that measured for a local BCG sample. If high redshift BCGs are in dynamical equilibrium and satisfy the same scaling relations as low redshift ones, this change in size would correspond to a mass growth of a factor of 2 since $z \sim 0.5$. However, the biweight-estimated WFPC2 effective radius of our sample is 18 $\pm$ 5.1 kpc, which is fully consistent with the local sample. While we can rule out mass accretion rates higher than a factor of 2 in our sample, the discrepancy between our NICMOS and WFPC2 results, which after various tests we describe appears to be physical, does not yet allow us to place strong constraints on accretion rates below that level.Comment: ApJ accepted (566, 1, February 2002), 12 pages, uses emulateapj5.st

A Hubble Space Telescope Snapshot Survey of Dynamically Close Galaxy Pairs in the CNOC2 Redshift Survey

We compare the structural properties of two classes of galaxies at intermediate redshift: those in dynamically close galaxy pairs, and those which are isolated. Both samples are selected from the CNOC2 Redshift Survey, and have redshifts in the range 0.1 < z <0.6. Hubble Space Telescope WFPC2 images were acquired as part of a snapshot survey, and were used to measure bulge fraction and asymmetry for these galaxies. We find that paired and isolated galaxies have identical distributions of bulge fractions. Conversely, we find that paired galaxies are much more likely to be asymmetric (R_T+R_A >= 0.13) than isolated galaxies. Assuming that half of these pairs are unlikely to be close enough to merge, we estimate that 40% +/- 11% of merging galaxies are asymmetric, compared with 9% +/- 3% of isolated galaxies. The difference is even more striking for strongly asymmetric (R_T+R_A >= 0.16) galaxies: 25% +/- 8% for merging galaxies versus 1% +/- 1% for isolated galaxies. We find that strongly asymmetric paired galaxies are very blue, with rest-frame B-R colors close to 0.80, compared with a mean (B-R)_0 of 1.24 for all paired galaxies. In addition, asymmetric galaxies in pairs have strong [OII]3727 emission lines. We conclude that close to half of the galaxy pairs in our sample are in the process of merging, and that most of these mergers are accompanied by triggered star formation.Comment: Accepted for publication in the Astronomical Journal. 40 pages, including 15 figures. For full resolution version, please see http://www.trentu.ca/physics/dpatton/hstpairs

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Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex.

Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin, a cytotoxic and anti-adipogenic natural product whose molecular mode of action was unknown. The new ternatin variants are cytotoxic toward cancer cells, with up to 500-fold greater potency than ternatin itself. Using a ternatin photo-affinity probe, we identify the translation elongation factor-1A ternary complex (eEF1A·GTP·aminoacyl-tRNA) as a specific target and demonstrate competitive binding by the unrelated natural products, didemnin and cytotrienin. Mutations in domain III of eEF1A prevent ternatin binding and confer resistance to its cytotoxic effects, implicating the adjacent hydrophobic surface as a functional hot spot for eEF1A modulation. We conclude that the eukaryotic elongation factor-1A and its ternary complex with GTP and aminoacyl-tRNA are common targets for the evolution of cytotoxic natural products

Observing the build-up of the colour-magnitude relation at redshift ~0.8

We analyse the rest-frame (U-V) colour-magnitude relation for 2 clusters at redshift 0.7 and 0.8, drawn from the ESO Distant Cluster Survey. By comparing with the population of red galaxies in the Coma cluster, we show that the high redshift clusters exhibit a deficit of passive faint red galaxies. Our results show that the red-sequence population cannot be explained in terms of a monolithic and synchronous formation scenario. A large fraction of faint passive galaxies in clusters today has moved onto the red sequence relatively recently as a consequence of the fact that their star formation activity has come to an end at z<0.8.Comment: 5 pages, 2 figures, to appear in Proc. of IAU Colloq. 195: "Outskirts of Galaxy Clusters: Intense Life in the Suburbs" -- minor typos correcte

Measurement of the Integrated Faraday Rotations of BL Lac Objects

We present the results of multi-frequency polarization VLA observations of radio sources from the complete sample of northern, radio-bright BL Lac objects compiled by H. Kuhr and G. Schmidt. These were used to determine the integrated rotation measures of 18 objects, 15 of which had never been measured previously, which hindered analysis of the intrinsic polarization properties of objects in the complete sample. These measurements make it possible to correct the observed orientations of the linear polarizations of these sources for the effect of Faraday rotation. The most probable origin for Faraday rotation in these objects is the Galactic interstellar medium. The results presented complete measurements of the integrated rotation measures for all 34 sources in the complete sample of BL Lac objects.Comment: 9 pages, 7 figure