Diffusion Process in a Flow

We establish circumstances under which the dispersion of passive contaminants in a forced, deterministic or random, flow can be consistently interpreted as a Markovian diffusion process. In case of conservative forcing the repulsive case only, $\vec{F}=\vec{\nabla }V$ with $V(\vec{x},t)$ bounded from below, is unquestionably admitted by the compatibility conditions. A class of diffusion processes is exemplified, such that the attractive forcing is allowed as well, due to an appropriate compensation coming from the "pressure" term. The compressible Euler flows form their subclass, when regarded as stochastic processes. We establish circumstances under which the dispersion of passive contaminants in a forced, deterministic or random, flow can be consistently interpreted as a Markovian diffusion process. In case of conservative forcing the repulsive case only, $\vec{F}=\vec{\nabla }V$ with $V(\vec{x},t)$ bounded from below, is unquestionably admitted by the compatibility conditions. A class of diffusion processes is exemplified, such that the attractive forcing is allowed as well, due to an appropriate compensation coming from the "pressure" term. The compressible Euler flows form their subclass, when regarded as stochastic processes.Comment: 10 pages, Late

Non-equilibrium phase transition in a sheared granular mixture

The dynamics of an impurity (or tracer particle) immersed in a dilute granular gas under uniform shear flow is investigated. A non-equilibrium phase transition is identified from an exact solution of the inelastic Boltzmann equation for a granular binary mixture in the tracer limit, where the impurity carries either a vanishing (disordered phase) or a finite (ordered phase) fraction of the total kinetic energy of the system. In the disordered phase, the granular temperature ratio (impurity "temperature" over that of the host fluid) is finite, while it diverges in the ordered phase. To correctly capture this extreme violation of energy equipartition, we show that the picture of an impurity enslaved to the host fluid is insufficient

Diffusion and Current of Brownian Particles in Tilted Piecewise Linear Potentials: Amplification and Coherence

Overdamped motion of Brownian particles in tilted piecewise linear periodic potentials is considered. Explicit algebraic expressions for the diffusion coefficient, current, and coherence level of Brownian transport are derived. Their dependencies on temperature, tilting force, and the shape of the potential are analyzed. The necessary and sufficient conditions for the non-monotonic behavior of the diffusion coefficient as a function of temperature are determined. The diffusion coefficient and coherence level are found to be extremely sensitive to the asymmetry of the potential. It is established that at the values of the external force, for which the enhancement of diffusion is most rapid, the level of coherence has a wide plateau at low temperatures with the value of the Peclet factor 2. An interpretation of the amplification of diffusion in comparison with free thermal diffusion in terms of probability distribution is proposed.Comment: To appear in PR

Broken symmetries and directed collective energy transport

We study the appearance of directed energy current in homogeneous spatially extended systems coupled to a heat bath in the presence of an external ac field E(t). The systems are described by nonlinear field equations. By making use of a symmetry analysis we predict the right choice of E(t) and obtain directed energy transport for systems with a nonzero topological charge Q. We demonstrate that the symmetry properties of motion of topological solitons (kinks and antikinks) are equivalent to the ones for the energy current. Numerical simulations confirm the predictions of the symmetry analysis and, moreover, show that the directed energy current drastically increases as the dissipation parameter $\alpha$ reduces. Our results generalize recent rigorous theories of currents generated by broken time-space symmetries to the case of interacting many-particle systems.Comment: 4 pages, 2 figure

Anatomy of the AGN in NGC 5548. III. The high-energy view with NuSTAR and INTEGRAL

We describe the analysis of the seven broad-band X-ray continuum observations of the archetypal Seyfert 1 galaxy NGC 5548 that were obtained with XMM-Newton or Chandra, simultaneously with high-energy (>10 keV) observations with NuSTAR and INTEGRAL. These data were obtained as part of a multiwavelength campaign undertaken from the summer of 2013 till early 2014. We find evidence of a high-energy cut-off in at least one observation, which we attribute to thermal Comptonization, and a constant reflected component that is likely due to neutral material at least a few light months away from the continuum source. We confirm the presence of strong, partial covering X-ray absorption as the explanation for the sharp decrease in flux through the soft X-ray band. The obscurers appear to be variable in column density and covering fraction on time scales as short as weeks. A fit of the average spectrum over the range 0.3–400 keV with a realistic Comptonization model indicates the presence of a hot corona with a temperature of 40^(+40)_(-10) keV and an optical depth of 2.7^(+0.7)_(-1.2) if a spherical geometry is assumed

Improving the dependability of AMR sensors used in automotive applications

Electronic systems are replacing mechanical parts to improve the safety and performance of the cars. However, the electronic components should be dependable, meaning they should be trusted to work properly over time. AMR sensors are widely used in automotive for angle measurements. Nevertheless, they are affected by performance degradation and catastrophic faults. Both should be handled to guarantee the correct operation of the sensor over time. This paper proposed two modules, fault-tolerant, and self-calibration. Results show they allow to improve the dependability of the sensor

A dependable AMR sensor system for automotive applications

The increasing replacement of mechanical parts by x-by-wire systems in automotive applications allows improving driver safety. These systems demand highly dependable sensors that ensure their functionality despite the harsh operating conditions. This means that the sensors should be capable of working continuously despite catastrophic faults and keeping the performance over time. An anisotropic magnetoresistance (AMR) sensor is a magnetic sensor commonly used for angle measurements in cars. It is affected by catastrophic faults and performance degradation due to undesired parameters included at the sensor outputs. Until now, physical redundancy is often used to handle catastrophic faults. For the performance, compensation factors for the undesired parameter, such as offset voltage, are estimated at the start of the sensor life. Although the undesired parameters drift due to aging effects, the sensor performance remains within the allowed tolerant band. However, this tolerant band will decrease in the future because the dependability requirements are continuously increasing. Therefore, it is necessary to consider strategies to guarantee the sensor performance over time. This paper proposes a system to improve the sensor dependability using analytical redundancy for catastrophic faults but also with self-x properties to maintain the sensor performance over time. Results indicate a dependability improvement in terms of reliability, with a reduction of 50% in the rate of uncovered failures. The safety requirement ASIL level D is satisfied, and with regard to maintainability, the sensor performance is maintained over time

Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI-60 screening, mitochondrial targeting, and apoptosis

Platinum complexes related to cisplatin, cis-[PtCl2(NH3)2], are successful anticancer drugs; however, other transition metal complexes offer potential for combating cisplatin resistance, decreasing side effects, and widening the spectrum of activity. Organometallic half-sandwich iridium (IrIII) complexes [Ir(Cpx)(XY)Cl]+/0 (Cpx = biphenyltetramethylcyclopentadienyl and XY = phenanthroline (1), bipyridine (2), or phenylpyridine (3)) all hydrolyze rapidly, forming monofunctional G adducts on DNA with additional intercalation of the phenyl substituents on the Cpx ring. In comparison, highly potent complex 4 (Cpx = phenyltetramethylcyclopentadienyl and XY = N,N-dimethylphenylazopyridine) does not hydrolyze. All show higher potency toward A2780 human ovarian cancer cells compared to cisplatin, with 1, 3, and 4 also demonstrating higher potency in the National Cancer Institute (NCI) NCI-60 cell-line screen. Use of the NCI COMPARE algorithm (which predicts mechanisms of action (MoAs) for emerging anticancer compounds by correlating NCI-60 patterns of sensitivity) shows that the MoA of these IrIII complexes has no correlation to cisplatin (or oxaliplatin), with 3 and 4 emerging as particularly novel compounds. Those findings by COMPARE were experimentally probed by transmission electron microscopy (TEM) of A2780 cells exposed to 1, showing mitochondrial swelling and activation of apoptosis after 24 h. Significant changes in mitochondrial membrane polarization were detected by flow cytometry, and the potency of the complexes was enhanced ca. 5× by co-administration with a low concentration (5 μM) of the γ-glutamyl cysteine synthetase inhibitor L-buthionine sulfoximine (L-BSO). These studies reveal potential polypharmacology of organometallic IrIII complexes, with MoA and cell selectivity governed by structural changes in the chelating ligands

Using a New Odour-Baited Device to Explore Options for Luring and Killing Outdoor-Biting Malaria Vectors: A Report on Design and Field Evaluation of the Mosquito Landing Box.

Mosquitoes that bite people outdoors can sustain malaria transmission even where effective indoor interventions such as bednets or indoor residual spraying are already widely used. Outdoor tools may therefore complement current indoor measures and improve control. We developed and evaluated a prototype mosquito control device, the 'Mosquito Landing Box' (MLB), which is baited with human odours and treated with mosquitocidal agents. The findings are used to explore technical options and challenges relevant to luring and killing outdoor-biting malaria vectors in endemic settings. Field experiments were conducted in Tanzania to assess if wild host-seeking mosquitoes 1) visited the MLBs, 2) stayed long or left shortly after arrival at the device, 3) visited the devices at times when humans were also outdoors, and 4) could be killed by contaminants applied on the devices. Odours suctioned from volunteer-occupied tents were also evaluated as a potential low-cost bait, by comparing baited and unbaited MLBs. There were significantly more Anopheles arabiensis, An. funestus, Culex and Mansonia mosquitoes visiting baited MLB than unbaited controls (P<=0.028). Increasing sampling frequency from every 120 min to 60 and 30 min led to an increase in vector catches of up to 3.6 fold (P<=0.002), indicating that many mosquitoes visited the device but left shortly afterwards. Outdoor host-seeking activity of malaria vectors peaked between 7:30 and 10:30pm, and between 4:30 and 6:00am, matching durations when locals were also outdoors. Maximum mortality of mosquitoes visiting MLBs sprayed or painted with formulations of candidate mosquitocidal agent (pirimiphos-methyl) was 51%. Odours from volunteer occupied tents attracted significantly more mosquitoes to MLBs than controls (P<0.001). While odour-baited devices such as the MLBs clearly have potential against outdoor-biting mosquitoes in communities where LLINs are used, candidate contaminants must be those that are effective at ultra-low doses even after short contact periods, since important vector species such as An. arabiensis make only brief visits to such devices. Natural human odours suctioned from occupied dwellings could constitute affordable sources of attractants to supplement odour baits for the devices. The killing agents used should be environmentally safe, long lasting, and have different modes of action (other than pyrethroids as used on LLINs), to curb the risk of physiological insecticide resistance