The impact of alkyl chain purity on lipid based nucleic acid delivery systems – is the utilization of lipid components with technical grade justified?

The physicochemical properties and transfection efficacies of two samples of a cationic lipid have been investigated and compared in 2D (monolayers at the air/liquid interface) and 3D (aqueous bulk dispersions) model systems using different techniques. The samples differ only in their chain composition due to the purity of the oleylamine (chain precursor). Lipid 8 (using the oleylamine of technical grade for cost-efficient synthesis) shows lateral phase separation in the Langmuir layers. However, the amount of attached DNA, determined by IRRAS, is for both samples the same. In 3D systems, lipid 8 p forms cubic phases, which disappear after addition of DNA. At physiological temperatures, both lipids (alone and in mixture with cholesterol) assemble to lamellar aggregates and exhibit comparable DNA delivery efficiency. This study demonstrates that non-lamellar structures are not compulsory for high transfection rates. The results legitimate the utilization of oleyl chains of technical grade in the synthesis of cationic transfection lipid

Thermal conductance of thin film YIG determined using Bayesian statistics

Thin film YIG (Y$_3$Fe$_5$O$_{12}$) is a prototypical material for experiments on thermally generated pure spin currents and the spin Seebeck effect. The 3-omega method is an established technique to measure the cross-plane thermal conductance of thin films, but can not be used in YIG/GGG (Ga$_3$Gd$_5$O$_{12}$) systems in its standard form. We use two-dimensional modeling of heat transport and introduce a technique based on Bayesian statistics to evaluate measurement data taken from the 3-omega method. Our analysis method allows us to study materials systems that have not been accessible with the conventionally used 3-omega analysis. Temperature dependent thermal conductance data of thin film YIG are of major importance for experiments in the field of spin-caloritronics. Here we show data between room temperature and 10 K for films covering a wide thickness range as well as the magnetic field effect on the thermal conductance between 10 K and 50 K

Determination of the spin-flip time in ferromagnetic SrRuO3 from time-resolved Kerr measurements

We report time-resolved Kerr effect measurements of magnetization dynamics in ferromagnetic SrRuO3. We observe that the demagnetization time slows substantially at temperatures within 15K of the Curie temperature, which is ~ 150K. We analyze the data with a phenomenological model that relates the demagnetization time to the spin flip time. In agreement with our observations the model yields a demagnetization time that is inversely proportional to T-Tc. We also make a direct comparison of the spin flip rate and the Gilbert damping coefficient showing that their ratio very close to kBTc, indicating a common origin for these phenomena

CacheZoom: How SGX Amplifies The Power of Cache Attacks

In modern computing environments, hardware resources are commonly shared, and parallel computation is widely used. Parallel tasks can cause privacy and security problems if proper isolation is not enforced. Intel proposed SGX to create a trusted execution environment within the processor. SGX relies on the hardware, and claims runtime protection even if the OS and other software components are malicious. However, SGX disregards side-channel attacks. We introduce a powerful cache side-channel attack that provides system adversaries a high resolution channel. Our attack tool named CacheZoom is able to virtually track all memory accesses of SGX enclaves with high spatial and temporal precision. As proof of concept, we demonstrate AES key recovery attacks on commonly used implementations including those that were believed to be resistant in previous scenarios. Our results show that SGX cannot protect critical data sensitive computations, and efficient AES key recovery is possible in a practical environment. In contrast to previous works which require hundreds of measurements, this is the first cache side-channel attack on a real system that can recover AES keys with a minimal number of measurements. We can successfully recover AES keys from T-Table based implementations with as few as ten measurements.Comment: Accepted at Conference on Cryptographic Hardware and Embedded Systems (CHES '17

Stealthy Deception Attacks Against SCADA Systems

SCADA protocols for Industrial Control Systems (ICS) are vulnerable to network attacks such as session hijacking. Hence, research focuses on network anomaly detection based on meta--data (message sizes, timing, command sequence), or on the state values of the physical process. In this work we present a class of semantic network-based attacks against SCADA systems that are undetectable by the above mentioned anomaly detection. After hijacking the communication channels between the Human Machine Interface (HMI) and Programmable Logic Controllers (PLCs), our attacks cause the HMI to present a fake view of the industrial process, deceiving the human operator into taking manual actions. Our most advanced attack also manipulates the messages generated by the operator's actions, reversing their semantic meaning while causing the HMI to present a view that is consistent with the attempted human actions. The attacks are totaly stealthy because the message sizes and timing, the command sequences, and the data values of the ICS's state all remain legitimate. We implemented and tested several attack scenarios in the test lab of our local electric company, against a real HMI and real PLCs, separated by a commercial-grade firewall. We developed a real-time security assessment tool, that can simultaneously manipulate the communication to multiple PLCs and cause the HMI to display a coherent system--wide fake view. Our tool is configured with message-manipulating rules written in an ICS Attack Markup Language (IAML) we designed, which may be of independent interest. Our semantic attacks all successfully fooled the operator and brought the system to states of blackout and possible equipment damage

Nonlinear Dynamics of the Perceived Pitch of Complex Sounds

We apply results from nonlinear dynamics to an old problem in acoustical physics: the mechanism of the perception of the pitch of sounds, especially the sounds known as complex tones that are important for music and speech intelligibility

Ferromagnetic Enhancement of CE-type Spin Ordering in (Pr,Ca)MnO3_3

We present resonant soft X-ray scattering (RSXS) results from small band width manganites (Pr,Ca)MnO$_3$, which show that the CE-type spin ordering (SO) at the phase boundary is stabilized only below the canted antiferromagnetic transition temperature and enhanced by ferromagnetism in the macroscopically insulating state (FM-I). Our results reveal the fragility of the CE-type ordering that underpins the colossal magnetoresistance (CMR) effect in this system, as well as an unexpected cooperative interplay between FM-I and CE-type SO which is in contrast to the competitive interplay between the ferromagnetic metallic (FM-M) state and CE-type ordering.Comment: Accepted for publication in Phys. Rev. Let