Investigation of highly efficient satellite solution methods

Methods for analyzing the stability of satellites are discussed. The subjects considered are: (1) time elements, (2) stabilization by external energy corrections, and (3) long term global solutions for the synchronous satellite. A set of canonical two-body elements referred to as Delaunay-similar elements is presented. In contrast to the classical Delaunay theory which has time as the independent variable, the D-S theory uses an independent variable which is a generalized true anomaly. The numerical integration of the canonical perturbation equations of these elements is developed

A singularity free analytical solution of artificial satellite motion with drag

The connection between the existing Delaunay-Similar and Poincare-Similar satellite theories in the true anomaly version is outlined for the J(2) perturbation and the new drag approach. An overall description of the concept of the approach is given while the necessary expansions and the procedure to arrive at the computer program for the canonical forces is delineated. The procedure for the analytical integration of these developed equations is described. In addition, some numerical results are given. The computer program for the algebraic multiplication of the Fourier series which creates the FORTRAN coding in an automatic manner is described and documented

Noise Impacts from Professional Dog Grooming Forced-Air Dryers

This study was designed to measure the sound output of four commonly used brands of forced-air dryers used by dog groomers in the United States. Many dog groomers have questions about the effect of this exposure on their hearing, as well as on the hearing of the dogs that are being groomed. Readings taken from each dryer at 1 meter (the likely distance of the dryer from the groomer and the dog) showed average levels ranging from 105.5 to 108.3 dB SPL or 94.8 to 108.0 dBA. Using the 90 dBA criterion required by the US Occupational Safety and Health Administration, dog groomers/bathers are at risk if exposure to the lowest intensity dryer (94.8 dBA) exceeds 4 hours per day. If the more stringent 85 dBA criterion and 3 dB tradeoff is applied, less than one hour of exposure is permissible in an 8 hour day. Cautions are recommended for any persons exposed to noise from forced-air dryers

Families of Canonical Transformations by Hamilton-Jacobi-Poincar\'e equation. Application to Rotational and Orbital Motion

The Hamilton-Jacobi equation in the sense of Poincar\'e, i.e. formulated in the extended phase space and including regularization, is revisited building canonical transformations with the purpose of Hamiltonian reduction. We illustrate our approach dealing with orbital and attitude dynamics. Based on the use of Whittaker and Andoyer symplectic charts, for which all but one coordinates are cyclic in the Hamilton-Jacobi equation, we provide whole families of canonical transformations, among which one recognizes the familiar ones used in orbital and attitude dynamics. In addition, new canonical transformations are demonstrated.Comment: 21 page

Ambient habitat noise and vibration at the Georgia Aquarium

Underwater and in-air noise evaluations were completed in performance pool systems at Georgia Aquarium under normal operating conditions and with performance sound tracks playing. Ambient sound pressure levels at in-pool locations, with corresponding vibration measures from life support system (LSS) pumps, were measured in operating configurations, from shut down to full operation. Results indicate noise levels in the low frequency ranges below 100 Hz were the highest produced by the LSS relative to species hearing thresholds. The LSS had an acoustic impact of about 10 dB at frequencies up to 700 Hz, with a 20 dB re 1 μPa impact above 1000 Hz

Superior antigen-specific CD4+ T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older

BACKGROUND: The effectiveness of trivalent influenza vaccines may be reduced in older versus younger adults because of age-related immunosenescence. The use of an adjuvant in such a vaccine is one strategy that may combat immunosenescence, potentially by bolstering T-cell mediated responses. METHODS: This observer-blind study, conducted in the United States (US) and Spain during the 2008-2009 influenza season, evaluated the effect of Adjuvant System AS03 on specific T-cell responses to a seasonal trivalent influenza vaccine (TIV) in >/=65 year-old adults.Medically-stable adults aged >/=65 years were randomly allocated to receive a single dose of AS03-adjuvanted TIV (TIV/AS03) or TIV. Healthy adults aged 18-40 years received only TIV. Blood samples were collected on Day 0, Day 21, Day 42 and Day 180. Influenza-specific CD4+ T cells, defined by the induction of the immune markers CD40L, IL-2, IFN-gamma, or TNF-alpha, were measured in ex vivo cultures of antigen-stimulated peripheral blood mononuclear cells. RESULTS: A total of 192 adults were vaccinated: sixty nine and seventy three >/=65 year olds received TIV/AS03 and TIV, respectively; and fifty 18 - 40 year olds received TIV. In the >/=65 year-old group on Day 21, the frequency of CD4+ T cells specific to the three vaccine strains was superior in the TIV/AS03 recipients to the frequency in TIV (p /=65 year-old recipients of TIV/AS03 than in the 18 - 40 year old recipients of TIV on Days 21 (p = 0.006) and 42 (p = 0.011). CONCLUSION: This positive effect of AS03 Adjuvant System on the CD4+ T-cell response to influenza vaccine strains in older adults could confer benefit in protection against clinical influenza disease in this population. TRIAL REGISTRATION: (Clinicaltrials.gov.). NCT00765076

International Circumpolar Surveillance System for Invasive Pneumococcal Disease, 1999–2005

Disease rates are high among indigenous persons in Arctic countries, and PCV7 has resulted in decreased rates in North American children

68Ga-FAPI and 18F-FAPI PET/CT for detection of nodal metastases prior radical cystectomy in high-risk urothelial carcinoma patients

IntroductionTo determine the best therapeutic strategy for muscle-invasive bladder cancer (BC), the accuracy of lymph node staging is of paramount importance. However, diagnostic performance of conventional computed tomography in BC prior to radical cystectomy (RC) remains unsatisfactory. There is an increased interest in evaluating 18F-FAPI PET/CT for hybrid imaging due to their logistical advantages compared to [68Ga]Ga-based FAPI tracers in clinical routine. Recently, the potential diagnostic value of [68Ga]Ga-FAPI- 46 PET/CT was demonstrated in BC. Thus, we aimed to examine the diagnostic performance of [18F]F-FAPI- 74 and [68Ga]Ga-FAPI- 46 PET/CT for preoperative evaluation of locoregional lymph node metastases.MethodsFifty-one patients underwent FAPI PET/CT with either [68Ga]Ga-FAPI- 46 (n = 23) or [18F]F-FAPI- 74 (n = 28) prior to RC and PLND. SUVmax, SUVmean and the ratio between the SUVmax of lymph nodes and the SUVmean of the background (SUVmax_lymph node/SUVmean_background) were assessed. Additionally, short axis diameter (SAD) for a representative lymph node were documented in each lymph node region (n = 123) and compared to histopathological findings. Each scan was interpreted visually and quantitatively. ROC-analyses were performed to determine cut-off values with highest diagnostic accuracy.Results20/123 (16.3%) lymph node regions showed UC lymph node metastases. Histopathologically positive lymph nodes were associated with a significantly higher FAPI uptake compared to negative lymph nodes regarding SUVmax, SUVmean values and SUVmax_lymph node/SUVmean_background ratios. Visual analysis based on FAPI uptake showed a sensitivity and specificity, PPV and NPV of 63.6%, 95.8%, 77.7%, and 92.0% for [68Ga]Ga-FAPI- 46 and 55.5%, 98.1%, 83.3%, and 93.1% for [18F]F-FAPI- 74, respectively. ROC analysis revealed an optimal cut-off for SUVmax, SUVmean and SUVmax_lymph node/SUVmean_background of 1.35, 1.20 and 5.95 for [68Ga]Ga-FAPI- 46 and 1.55, 1.25 and 4.15 for [18F]F-FAPI- 74 to discriminate between histopathologically proven lymph node metastases and non-malignant lymph nodes resulting for example using SUVmax in a sensitivity and specificity, PPV and NPV of 81.8%, 89.5%, 64.2%, 95.5% for [68Ga]Ga-FAPI- 46 and 100%, 81.8%, 47.3%, 100% for [18F]F-FAPI- 74, respectively. CT visual analysis of locoregional lymph nodes showed a sensitivity, specificity, PPV and NPV of 30.0%, 97.0%, 66.6% and 87.7%, respectively. ROC analysis regarding SAD revealed a cutoff at 0.8 cm with a sensitivity, specificity, PPV and NPV of 75.0%, 84.4%, 48.3%, 94.5%, respectively.ConclusionOverall, FAPI PET imaging shows a significantly higher sensitivity than CT analysis for detection of locoregional lymph node metastases in UC. [18F]F-FAPI- 74 demonstrates a comparable diagnostic performance compared to [68Ga]Ga-FAPI- 46. Of note, the quantitative analysis with a pre-defined SUVmax as well as SUVmean values, and SUVmax_lymph node/SUVmean_background ratio-based cut-offs provided a higher sensitivity compared to visual assessment

Epidemiology of Haemophilus influenzae Serotype a, North American Arctic, 2000–2005

Serotype a is now the most common seen in the North American Arctic; highest rates occur in indigenous children

Epidemiology of Haemophilus influenzae Serotype a, North American Arctic, 2000–2005

Serotype a is now the most common seen in the North American Arctic; highest rates occur in indigenous children