A chronological framework for colluviation during the last 110 kyr in KwaZulu/Natal

Luminescence dating techniques have been applied to colluvial sediments of the Masotcheni Formation. The ages obtained suggest that colluvial deposition occurred during late Oxygen Isotope Stage 5, after the peak of the Last Interglacial (Sub-stage 5e). Further colluvial deposition seems to have commenced early in Stage 3, following a period of donga erosion. A soil was then formed during Stage 3 in the top of this deposit at two of the sites, and this was covered by more colluvial deposits before Stage 3 ended. Evidence for late Holocene colluviation is also presented. -from Authorspublished_or_final_versio

Comparison of breast and bowel cancer screening uptake patterns in a common cohort of South Asian women in England

Background: Inequalities in uptake of cancer screening by ethnic minority populations are well documented in a number of international studies. However, most studies to date have explored screening uptake for a single cancer only. This paper compares breast and bowel cancer screening uptake for a cohort of South Asian women invited to undertake both, and similarly investigates these women's breast cancer screening behaviour over a period of fifteen years. Methods: Screening data for rounds 1, 2 and 5 (1989-2004) of the NHS breast cancer screening programme and for round 1 of the NHS bowel screening pilot (2000-2002) were obtained for women aged 50-69 resident in the English bowel screening pilot site, Coventry and Warwickshire, who had been invited to undertake breast and bowel cancer screening in the period 2000-2002. Breast and bowel cancer screening uptake levels were calculated and compared using the chi-squared test. Results: 72,566 women were invited to breast and bowel cancer screening after exclusions. Of these, 3,539 were South Asian and 69,027 non-Asian; 18,730 had been invited to mammography over the previous fifteen years (rounds 1 to 5). South Asian women were significantly less likely to undertake both breast and bowel cancer screening; 29.9% (n = 1,057) compared to 59.4% (n = 40,969) for non-Asians (p < 0.001). Women in both groups who consistently chose to undertake breast cancer screening in rounds 1, 2 and 5 were more likely to complete round 1 bowel cancer screening. However, the likelihood of completion of bowel cancer screening was still significantly lower for South Asians; 49.5% vs. 82.3% for non-Asians, p < 0.001. South Asian women who undertook breast cancer screening in only one round were no more likely to complete bowel cancer screening than those who decided against breast cancer screening in all three rounds. In contrast, similar women in the non-Asian population had an increased likelihood of completing the new bowel cancer screening test. The likelihood of continued uptake of mammography after undertaking screening in round 1 differed between South Asian religio-linguistic groups. Noticeably, women in the Muslim population were less likely to continue to participate in mammography than those in other South Asian groups. Conclusions: Culturally appropriate targeted interventions are required to reduce observed disparities in cancer screening uptakes

Revisited and revalorized: Technological and refitting studies at the Middle Stone Age open-air knapping site Jojosi 1 (KwaZulu-Natal, South Africa).

The Middle Stone Age (MSA) of southern Africa is mainly known from rock shelters and caves. How early modern humans interacted with their landscapes remains comparatively understudied. The site of Jojosi 1, situated north of Nquthu in north central KwaZulu-Natal, is set within erosional badlands known locally as ‘dongas’. This locality offers a rare opportunity to study MSA technology and settlement dynamics in an open-air context. G. Botha initially discovered Jojosi 1 in 1991. He brought it to A. Mazel’s attention who excavated the site in the same year, but did not publish the lithic assemblage. Here, we report on the site’s rediscovery coupled with the first lithic analysis and luminescence dating. This work provides insights into the site formation processes of Jojosi 1 and lithic reduction strategies, raw material provisioning, and landscape use. Our techno-typological analysis draws upon Mazel’s collection of 7529 artefacts, combining attribute analysis and refitting studies. The results show the exclusive use of hornfels and its reduction via platform cores and Levallois methods to pro- duce flakes and blades. Retouched tools are scarce and comprise mostly notched or denticulate pieces but lack backed tools, unifacial, and bifacial points. The museum collection features abundant small debitage and a strong component of cortical, initial stage, and core preparation flakes. The 48 refitted artefacts and ample small debitage in a spatially constricted band suggest high assemblage integrity with minimal post-depositional disturbance. Infrared stimulated luminescence dating of coarse grain feldspars brackets the archaeological occurrence to ~139–106 ka. Comparisons with contemporary lithic assem- blages link the assemblage to the early MSA in southern Africa. We interpret Jojosi 1 as a knapping event aimed at blank production and exploitation of local high-quality hornfels. With little evidence for other behaviours, the site likely reflects a short-term knapping workshop on a source of abundant hornfels slabs. Our ongoing excavations in the Jojosi Dongas will be able to test this hypothesis and will work to characterise the technological adaptations and settlement dynamics of the MSA hunter-gatherers in this area

LCA applied to perennial cropping systems: a review focused on the farm stage

International audienc

Quartz crystal microbalance as a device to measure the yield stress of colloidal suspensions

The application of quartz crystal microbalance (QCM) as a device to measure the rheology of colloidal suspensions has been studied. Using a commercial dip-probe QCM, the yield stress of magnesium hydroxide suspensions has been correlated to the resonance properties of a 5 MHz AT-cut quartz sensor. A stable resonance baseline was first established in air before submerging the sensor into the colloidal suspension. The response of the sensor resistance was shown to correlate to changes in the suspension yield stress, while the frequency response was found to result from more complex contact mechanics and suspension viscoelasticity contributions. Since the QCM is a relatively simple technique with no mechanically moving parts, this approach offers the potential for rapid in situ rheology assessment

A Novel Technology for Complex Rheological Measurements

As the UK nuclear industry embarks on a second phase of nuclear power generation, the industry is faced with numerous sludge and slurry challenges associated with the decommissioning and clean-up of historical nuclear sites. The remediation of Sellafield, the largest nuclear site in the UK, is anticipated to cost GBP 53bn over the next 100 years. Substantial cost is associated with the clean-up, transfer and safe storage of legacy particulate wastes encountered in ponds, silos, highly active storage tanks and many more large tanks on site. To develop suitable design strategies for the mobilization and transfer of sludge, the rheology of the sludge should be accurately determined. The current work demonstrates the use of a Quartz Crystal Microbalance to measure sludge rheology, specifically the shear yield stress. The device is simple to operate with no mechanical parts, small and portable enabling deployment into limited access areas, and eliminates the need for operator sampling and laboratory measurement. The measurement principle relates to the resonance frequency and motional resistance of a piezo-electric sensor as the sensor is submerged in the desired test material. The air-to-sample frequency and resistance shifts are shown to correlate with the shear yield stress of the suspension as measured by conventional vane viscometry. As the particle network stiffens (increased yield stress), the sensor motional resistance and its resonant frequency become more positive These characteristic responses and their correlation to the shear yield stress have been confirmed for a range of particle suspensions

On the avoidability of breast cancer in industrialized societies: older mean age at first birth as an indicator of excess breast cancer risk

Background Breast cancer incidence continuous to increase. We examined at population level the association between the relative excess risk of breast cancer and previous age of mother at first birth. Method Incidence of breast cancer in 34 industrialized countries was obtained from the GLOBOCAN 2002 and SEER databases. Data on age of mother at first birth was collected through national statistics offices. National relative excess risk (RER) was calculated by subtracting the lowest age-specific incidence rate from the rate in each population, and dividing the difference by the latter. Results The national RER in 2002 correlated closely with a higher average age at first birth in 1972, 1982, 1992 and also 2002, Pearson correlation [r] being 0.83, 0.79, 0.72 and 0.61, respectively; P < 0.0001. RER of breast cancer in 2002 for those aged 15–44 years correlated closely with the mean age at first birth in 1982 and 1992 (r: 0.81 and 0.75; P < 0.0001), whereas RER for those aged 45–54 years correlated strongly with age at first birth in 1972 and 1982 (r: 0.81 and 0.76; P < 0.0001), and for those aged 55–64 years with age at first birth in 1972 (r: 0.77; P < 0.0001). Conclusions The rising age at first childbirth of mothers has been followed by marked increases in breast cancer incidence. Later age at first birth seems to characterize secular diffusion of ‘modern’ lifestyles with a potentially large impact on increased breast cancer risk, and hence should be accompanied by greater opportunities for prevention through modifiable risk factors

The apoptosis-inducing activity towards leukemia and lymphoma cells in a cyanobacterial culture collection is not associated with mouse bioassay toxicity

Cyanobacteria (83 strains and seven natural populations) were screened for content of apoptosis (cell death)-inducing activity towards neoplastic cells of the immune (jurkat acute T-cell lymphoma) and hematopoetic (acute myelogenic leukemia) lineage. Apoptogenic activity was frequent, even in strains cultured for decades, and was unrelated to whether the cyanobacteria had been collected from polar, temperate, or tropic environments. The activity was more abundant in the genera Anabaena and Microcystis compared to Nostoc, Phormidium, Planktothrix, and Pseudanabaena. Whereas the T-cell lymphoma apoptogens were frequent in organic extracts, the cell death-inducing activity towards leukemia cells resided mainly in aqueous extracts. The cyanobacteria were from a culture collection established for public health purposes to detect toxic cyanobacterial blooms, and 54 of them were tested for toxicity by the mouse bioassay. We found no correlation between the apoptogenic activity in the cyanobacterial isolates with their content of microcystin, nor with their ability to elicit a positive standard mouse bioassay. Several strains produced more than one apoptogen, differing in biophysical or biological activity. In fact, two strains contained microcystin in addition to one apoptogen specific for the AML cells, and one apoptogen specific for the T-cell lymphoma. This study shows the potential of cyanobacterial culture collections as libraries for bioactive compounds, since strains kept in cultures for decades produced apoptogens unrelated to the mouse bioassay detectable bloom-associated toxins

The Ontogenetic Osteohistology of Tenontosaurus tilletti

Tenontosaurus tilletti is an ornithopod dinosaur known from the Early Cretaceous (Aptian-Albian) Cloverly and Antlers formations of the Western United States. It is represented by a large number of specimens spanning a number of ontogenetic stages, and these specimens have been collected across a wide geographic range (from central Montana to southern Oklahoma). Here I describe the long bone histology of T. tilletti and discuss histological variation at the individual, ontogenetic and geographic levels. The ontogenetic pattern of bone histology in T. tilletti is similar to that of other dinosaurs, reflecting extremely rapid growth early in life, and sustained rapid growth through sub-adult ontogeny. But unlike other iguanodontians, this dinosaur shows an extended multi-year period of slow growth as skeletal maturity approached. Evidence of termination of growth (e.g., an external fundamental system) is observed in only the largest individuals, although other histological signals in only slightly smaller specimens suggest a substantial slowing of growth later in life. Histological differences in the amount of remodeling and the number of lines of arrested growth varied among elements within individuals, but bone histology was conservative across sampled individuals of the species, despite known paleoenvironmental differences between the Antlers and Cloverly formations. The bone histology of T. tilletti indicates a much slower growth trajectory than observed for other iguanodontians (e.g., hadrosaurids), suggesting that those taxa reached much larger sizes than Tenontosaurus in a shorter time

Potentially pathogenic yeasts from soil of children’s recreational areas in the city of Łódź (Poland)

Objectives: Yeasts may become potential human and animal pathogens, particularly for individuals with a depressed immune system. Their presence in the environment, especially in soil, may favour their spread into human ontocenoses. Materials and Methods: Eighty-four soil samples obtained from 21 children's recreational sites in Łódź in autumn 2010 and spring 2011 were evaluated. The yeasts were isolated by classical microbiological methods and identified on the basis of morphological and biochemical features. Results: The fungi were found in 73.8% and in 69.0% of the examined samples collected in autumn and spring, respectively. Among 97 isolates of yeasts, the species potentially pathogenic to humans and animals were Candida colliculosa, C. guilliermondii, C. humicola, C. inconspicua, C. lambica, C. lusitaniae, C. pelliculosa, C. tropicalis, Cryptococcus albidus, C. laurentii, C. neoformans, C. terreus, Kloeckera japonica, Geotrichum candidum, G. penicillatum, Rhodotorula mucilaginosa, R. glutinis, Saccharomyces cerevisiae, Sporobolomyces salmonicolor and Trichosporon cutaneum. The most frequently isolated fungi included the genus Cryptococcus (38 isolates) and two species: Rhodotorula glutinis (15), Trichosporon cutaneum (14). C. neoformans, an etiological factor of cryptococcal meningitis, was present in the sandpits of 3 kindergartens. The Candida species were identified from park playgrounds and school sports fields mainly in autumn 2010 (14 isolates), in spring 2011 - only 1 isolate. The concentration of fungal species in particular samples varied considerably, but in the majority of samples, fungi were present at concentration of up to 1×102 CFU/1 g of soil. Conclusions: Yeasts were present in the soil of parks, schools and kindergarten recreational areas; the fact may pose a health risk to humans, especially to children, and this type of biological pollution should be regarded as a potential public health concern