Soret driven convection in a colloidal solution heated from above at very large solutal Rayleigh number

Convection in a colloidal suspension with a large negative separation ratio is studied experimentally by heating from above. Shadowgraph observation at very large solutal Rayleigh numbers are reported as a function of time. Fast relaxation oscillations are reported for the root mean square value of the shadowgraph intensity. While pure fluids exhibit a transition to turbulent convection for Rayleigh number of about 10^6, stable spoke-pattern planform with up and down columnar flows are observed up to solutal Rayleigh numbers of the order of 10^9. It is suggested that the surprising stability of the planform against turbulence is due to nonlinear focusing arising from the concentration dependence of the diffusion coefficient.Comment: 10 pages, 4 figure

Application of the continuum damage mechanics model in the three point bending test of Ti-6Al-4V titanium alloy specimens

One of the most important and challenging activities in the simulation of the mechanical behaviour of materials is the prediction of the failure phenomena. If well calibrated, damage models can simulate and predict the failure of materials in a generalized way allowing the replication of not only the calibration tests themselves but also of different loading cases. Generally damage models can be categorized into three different groups including phenomenological models, porosity models and continuum damage mechanics (CDM) models. Different CDM models have been proposed by researchers and these models have been applied in diverse loading conditions, geometries and materials. However the limitations and advantages of the CDM models are still not completely explored in the application areas. In this paper, a CDM model, (previously calibrated with round smooth specimen) has been applied in a three-point bending test model in order to simulate the correlated experiment. Specifically, the CDM framework has been applied in a finite element model and the obtained results have been compared with the experimental data. The tested material is Ti-6Al-4V titanium alloy, which is a widely used material in the aerospace industry because of its high strength and low density. Load-displacement data in the experiments and numerical simulations are the main results, which have been compared. Therefore, the ability of the CDM model to simulate the three point bending test has been investigated and the results are discussed

A preliminary study of multi-parameter POD curves for a guided waves based SHM approach to lightweight materials

In view of an extensive literature about guided waves propagation, interaction and numerical simulation in platelike structures made of metallic and composite materials, a lack of information is pointed out regarding their reliability in structural health monitoring approaches. Typically, because of uncertainties in the inspection process, the capability of nondestructive testing systems is expressed by means of suitable probability of detection curves. Based on Berens’ model, a linear relationship is established between probability of detection and flaw size. Although the uncertain factors differ from a nondestructive inspection technique and a structural health monitoring approach, the same mathematical framework can be assumed. Hence, the authors investigated the application of a recently developed non-destructive testing Multi-Parameter POD approach to a guided waves based SHM one: numerical simulations as well as experimental data from flawed plates were combined to bring about a “master” POD curve. Once established, it can be used to build the POD curves of the single key factors as flaw size, orientation, structural attenuation and so on

Valutazione della capacità di rientro alla base di un elicottero in presenza di danno balistico ad un albero di trasmissione della linea rotore di coda

Nella progettazione di un elicottero militare, destinato ad operare a bassa quota e in ambiente ostile, il danneggiamento di componenti critici, conseguente ad impatto balistico, riveste un ruolo primario nella valutazione delle possibilità di sopravvivenza dell’intera macchina. In questo articolo è quindi proposto uno studio sperimentale, suddiviso in diverse fasi, riguardante la verifica della capacità di un elicottero di portare a termine una missione di rientro alla base a potenza ridotta e in presenza di danneggiamento balistico ad un albero di trasmissione della linea rotore di coda. Il lavoro ha richiesto dapprima l’esecuzione, su esemplari del componente in esame, di prove sperimentali di impatto balistico, condotte utilizzando un proiettile calibro 7.62 NATO. Successivamente su ciascun albero danneggiato sono state eseguite prove torsionali statiche ed a fatica, il cui scopo è stato verificare la resistenza residua del componente all’applicazione di opportuni carichi rappresentativi delle sollecitazioni riscontrate durante la missione di rientro

A schlieren method for ultra-low angle light scattering measurements

We describe a self calibrating optical technique that allows to perform absolute measurements of scattering cross sections for the light scattered at extremely small angles. Very good performances are obtained by using a very simple optical layout similar to that used for the schlieren method, a technique traditionally used for mapping local refraction index changes. The scattered intensity distribution is recovered by a statistical analysis of the random interference of the light scattered in a half-plane of the scattering wave vectors and the main transmitted beam. High quality data can be obtained by proper statistical accumulation of scattered intensity frames, and the static stray light contributions can be eliminated rigorously. The potentialities of the method are tested in a scattering experiment from non equilibrium fluctuations during a free diffusion experiment. Contributions of light scattered from length scales as long as Lambda=1 mm can be accurately determined.Comment: 7 pages, 3 figure

MicroRNA-551b expression profile in low and high-grade cervical intraepithelial neoplasia

OBJECTIVE: To evaluate the expression of microRNA (miR)-551b in patients with low and high grade cervical intraepithelial neoplasia (CIN) and to find an association with high-risk Human Papillomavirus (HR-HPV) infection-related prognostic biomarkers. PATIENTS AND METHODS: The expression level of miR-551b was determined in 50 paraffin-embedded cervical specimens (10 normal squamous epithelium, 18 condylomas, 8 CIN1, and 14 CIN2-3) using quantitative Real-time polymerase chain reaction (qRT-PCR). χ2-test compared miR-551b expression in different diagnosis groups. An Ordered Logistic Regression and a Probit correlation were made to correlate miR-551b expression levels with the cervical tissue histological findings. The immunohistochemical distribution of p16 and Ki-67 according to histopathological findings was also assessed. RESULTS: The distribution of the miR-551b expression profile was significantly lower in CIN1-3 samples compared to other histological diagnosis groups (condyloma and negative). The expression levels were inversely correlated to the cervical pathological grade, from negative to CIN2-3. A 1% increase in miR-551b expression level produced an increase of 19% to the probability of a minor histological grade diagnosis in a range from negative to CIN2-3 and an increase of 13% to the probability of a negative histological grade diagnosis. Among the cases with miR-551b expression < 0.02 (considered as cut-off value) a significant statistical correlation was found between p16 and Ki-67 expression and the diagnosis of CIN2-3. CONCLUSIONS: O ur d ata s howed a s ignificant inverse correlation between miR-551b expression and the histological grading of the lesions, suggesting a tumor suppressive function in the different stages of cervical dysplasia

Valutazione della capacità di rientro alla base di un elicottero in presenza di danno balistico ad un albero di trasmissione della linea rotore di coda

Nella progettazione di un elicottero militare, destinato ad operare a bassa quota e in ambienteostile, il danneggiamento di componenti critici, conseguente ad impatto balistico, riveste un ruolo primario nellavalutazione delle possibilità di sopravvivenza dell’intera macchina. In questo articolo è quindi proposto unostudio sperimentale, suddiviso in diverse fasi, riguardante la verifica della capacità di un elicottero di portare atermine una missione di rientro alla base a potenza ridotta e in presenza di danneggiamento balistico ad unalbero di trasmissione della linea rotore di coda.Il lavoro ha richiesto dapprima l’esecuzione, su esemplari del componente in esame, di prove sperimentali diimpatto balistico, condotte utilizzando un proiettile calibro 7.62 NATO. Successivamente su ciascun alberodanneggiato sono state eseguite prove torsionali statiche ed a fatica, il cui scopo è stato verificare la resistenzaresidua del componente all’applicazione di opportuni carichi rappresentativi delle sollecitazioni riscontratedurante la missione di rientro

Heterodyne near-field scattering: A technique for complex fluids

The heterodyne near-field scattering (HNFS) technique for studying complex fluids such as colloidal systems was discussed. A different data reduction scheme was adopted which allowed the improvement in performance of the technique, at levels of sensitivity and accuracy much higher than those achievable with classical low-angle light scattering instrumentation. It was observed that this method also relaxes the requirements on the optical/mechanical stability of the experimental setup and allows for a real time analysis. Nonstationary samples, such as aggregating colloidal solutions, were also investigated, and their kinetics quantitatively characterized

Are immune responses gender-related in Carabus lefebvrei (Coleoptera: Carabidae)?

The \u201clive hard, die young\u201d theory predicts the evolution of gender differences in immunocompetence, with males having a weaker immune system than females. To test this hypothesis in Carabus lefebvrei, total and basal phenoloxidase (PO) activities and lysozyme-like enzyme activity were compared among males and females of different reproductive status. The sexual dimorphism occurred only in reproductively active adults and for total and basal PO levels, while no significant differences were recorded between sexes in virgin adults. Differences were not recorded for lytic activity between sexes. Basal PO and lytic activities decreased in both males and females after mating, while the total PO value increased in males and decreased in females. Thus, resources seem to be invested to increase the humoral response in pre-reproductive phase forming a barrier against pathogens and preserving the fecundity and longevity of both sexes. Males preserve their survivorship in reproductive phase by increasing enzymatic levels in hemolymph to avoid fitness reduction due to the increased exposure to pathogen as result of mating. Females shift resources from PO and lytic activity to other physiological systems involved in reproduction in order to maximize their fitness