Normal component of TMS-induced electric field is correlated with depressive symptom relief in treatment-resistant depression

202302 bcwwVersion of RecordRGCOthersAustrian Science Fund (FWF) [grant number KLI 551, PI: S. Kasper]General Research Fund (GRF) under the University Grants Committee (UGC) of the Hong Kong Special Administrative Region [grant numbers 15100120 and 25100219, PI: G.S. Kranz]Publishe

The impact of theta-burst stimulation on cortical GABA and glutamate in treatment-resistant depression : a surface-based MRSI analysis approach

202309 bcvcVersion of RecordOthersLundbeck; Siemens HealthcarePublishe

Effects of bilateral sequential theta-burst stimulation on functional connectivity in treatment-resistant depression : first results

202310 bcvcVersion of RecordOthersAustrian Science FundPublishe

The impact of theta-burst stimulation on cortical GABA and glutamate in treatment-resistant depression: A surface-based MRSI analysis approach

AbstractBackgroundTheta burst stimulation (TBS) belongs to one of the biological antidepressant treatment options. When applied bilaterally, excitatory intermittent TBS (iTBS) is commonly targeted to the left and inhibitory continuous TBS (cTBS) to the right dorsolateral prefrontal cortex. TBS was shown to influence neurotransmitter systems, while iTBS is thought to interfere with glutamatergic circuits and cTBS to mediate GABAergic neurotransmission.ObjectivesWe aimed to expand insights in the therapeutic effects of TBS on the GABAergic and glutamatergic system utilizing 3D-multivxovel magnetic resonance spectroscopy imaging (MRSI) in combination with a novel surface-based MRSI analysis approach to investigate changes of cortical neurotransmitter levels in patients with treatment resistant depression (TRD).MethodsTwelve TRD patients (5 female, mean age±SD=35±11 years) completed paired MRSI measurements, using a GABA-edited 3D-multivoxel MEGA-LASER sequence, before and after three weeks of bilateral TBS treatment. Changes in cortical distributions of GABA+/tNAA (GABA+macromolecules relative to total N-acetylaspartate) and Glx/tNAA (Glx=mixed signal of glutamate and glutamine), were investigated in a surface-based region-of-interest (ROI) analysis approach.ResultsANCOVAs revealed a significant increase in Glx/tNAA ratios in the left caudal middle frontal area (pcorr.=0.046, F=13.292), an area targeted by iTBS treatment. Whereas, contralateral treatment with cTBS evoked no alterations in glutamate or GABA concentrations.ConclusionThis study demonstrates surface-based adaptions in the stimulation area to the glutamate metabolism after excitatory iTBS but not after cTBS, using a novel surface-based analysis of 3D-MRSI data. The reported impact of facilitatory iTBS on glutamatergic neurotransmission provides further insight into the neurobiological effects of TBS in TRD.</jats:sec

Changes to hypothalamic volume and associated subunits during gender-affirming hormone therapy

202411 bcchVersion of RecordOthersAustrian Science Fund (FWF); Austrian Academy of Sciences at the Department of Psychiatry and Psychotherapy, Medical University of Vienna; MDPhD Excellence Program of the Medical University of Vienna; Austrian National Union of Students; NARSAD Young Investigator grant; Austrian Science Fund Project; Medizinisch-Wissenschaftlichen Fonds des Bürgermeisters der Bundeshauptstadt Wien Project; Interdisciplinary translational brain research cluster (ITHC) with highfield MR from the Federal Ministry of Science; Research and Economy (BMWFW), AustriaPublishedC