Sex Differences in Social Attention in Infants at Risk for Autism

We studied visual attention to emotional faces in 10-month-old infant siblings of children with ASD (ASD-sibs; N = 70) and a siblings of typically developing children (N = 29) using static stimuli. Contrary to our predictions, we found no evidence for atypical gaze behavior in ASD-sibs when boys and girls were analyzed together. However, a sex difference was found in ASD-sibs' visual attention to the mouth. Male ASD-sibs looked more at the mouth across emotions compared to male controls and female ASD-sibs. In contrast, female ASD-sibs looked less at the mouth compared to female controls. These findings suggest that some aspects of early emerging atypical social attention in ASD-sibs may be sex specific

On-line mass spectrometry: membrane inlet sampling

Significant insights into plant photosynthesis and respiration have been achieved using membrane inlet mass spectrometry (MIMS) for the analysis of stable isotope distribution of gases. The MIMS approach is based on using a gas permeable membrane to enable the entry of gas molecules into the mass spectrometer source. This is a simple yet durable approach for the analysis of volatile gases, particularly atmospheric gases. The MIMS technique strongly lends itself to the study of reaction flux where isotopic labeling is employed to differentiate two competing processes; i.e., O2 evolution versus O2 uptake reactions from PSII or terminal oxidase/rubisco reactions. Such investigations have been used for in vitro studies of whole leaves and isolated cells. The MIMS approach is also able to follow rates of isotopic exchange, which is useful for obtaining chemical exchange rates. These types of measurements have been employed for oxygen ligand exchange in PSII and to discern reaction rates of the carbonic anhydrase reactions. Recent developments have also engaged MIMS for online isotopic fractionation and for the study of reactions in inorganic systems that are capable of water splitting or H2 generation. The simplicity of the sampling approach coupled to the high sensitivity of modern instrumentation is a reason for the growing applicability of this technique for a range of problems in plant photosynthesis and respiration. This review offers some insights into the sampling approaches and the experiments that have been conducted with MIMS

Behavioral Profiles of Affected and Unaffected Siblings of Children with Autism: Contribution of Measures of Mother–Infant Interaction and Nonverbal Communication

We investigated whether deficits in social gaze and affect and in joint attention behaviors are evident within the first year of life among siblings of children with autism who go on to be diagnosed with autism or ASD (ASD) and siblings who are non-diagnosed (NoASD-sib) compared to low-risk controls. The ASD group did not differ from the other two groups at 6 months of age in the frequency of gaze, smiles, and vocalizations directed toward the caregiver, nor in their sensitivity to her withdrawal from interaction. However, by 12 months, infants in the ASD group exhibited lower rates of joint attention and requesting behaviors. In contrast, NoASD-sibs did not differ from comparison infants on any variables of interest at 6 and 12 months

Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)

17β-estradiol (E2), the most potent estrogen in humans, known to be involved in the development and progession of estrogen-dependent diseases (EDD) like breast cancer and endometriosis. 17β-HSD1, which catalyses the reduction of the weak estrogen estrone (E1) to E2, is often overexpressed in breast cancer and endometriotic tissues. An inhibition of 17β-HSD1 could selectively reduce the local E2-level thus allowing for a novel, targeted approach in the treatment of EDD. Continuing our search for new nonsteroidal 17β-HSD1 inhibitors, a novel pharmacophore model was derived from crystallographic data and used for the virtual screening of a small library of compounds. Subsequent experimental verification of the virtual hits led to the identification of the moderately active compound 5. Rigidification and further structure modifications resulted in the discovery of a novel class of 17β-HSD1 inhibitors bearing a benzothiazole-scaffold linked to a phenyl ring via keto- or amide-bridge. Their putative binding modes were investigated by correlating their biological data with features of the pharmacophore model. The most active keto-derivative 6 shows IC50-values in the nanomolar range for the transformation of E1 to E2 by 17β-HSD1, reasonable selectivity against 17β-HSD2 but pronounced affinity to the estrogen receptors (ERs). On the other hand, the best amide-derivative 21 shows only medium 17β-HSD1 inhibitory activity at the target enzyme as well as fair selectivity against 17β-HSD2 and ERs. The compounds 6 and 21 can be regarded as first benzothiazole-type 17β-HSD1 inhibitors for the development of potential therapeutics

Intimate Partner Violence Victimization Among Non-Heterosexuals: Prevalence and Associations With Mental and Sexual Well-Being

This study focused on intimate partner violence (IPV) among non-heterosexuals in Flanders. Prevalence rates were explored and compared with heterosexual IPV using a first representative sample consisting of 1690 heterosexuals and non-heterosexual individuals. A second convenience sample consisting of 2401 non-heterosexual individuals was used to determine differences between women and men and to explore associations between IPV and victims' well-being. Physical and psychological IPV inflicted by the current/former partner were reported by 14.5 and 57.9 % of the non-heterosexuals, respectively. Non-heterosexuals and heterosexuals were equally likely to report physical and psychological IPV. Furthermore, non-heterosexual women and men reported similar physical, sexual, and psychological IPV. However, female victims experienced more frequent acts of psychological IPV. IPV was negatively associated with victims' well-being

'Where "Daddy" and Danger Were': The Portrayal of Children in War Illustrated, 1914-1916

This paper examines the representation of children in the popular British World War I publication, War Illustrated. Images of children occur within several contexts, linked to dominant contemporary propaganda discourses. These include concepts of national mobilisation within total war, qualities of sacrifice, endurance and patriotism, and the demonization of German tactics of ‘frightfulness’ (i.e. atrocities inflicted upon civilians). The magazine’s visual representations of children, in photographs and illustrations by war artists, mobilise them as resources in propaganda, to support the prosecution of the war through the propagation of patriotic principles and the vilification of the enemy. Images of women and children in Europe in reinforcing contemporary propaganda discourses (such as the pervasive ‘rape of Belgium’ narrative), but children in Britain become symbols of the ideals of family and country which British soldiers must defend. However, beyond their representation as victims of the war, children are also represented as participants in the conflict, in some cases assuming the status of combatants comparable to that of adults. This adaptation of children’s roles is matched and eventually overtaken in the magazine’s images by the transformation of the status of women, and their burgeoning contribution to the war effort as the conflict continues

B-lymphoblastic leukemia/lymphoma arising in treated plasma cell myeloma: A rare second malignancy

Plasma cell myeloma (PCM) is a neoplasm of plasma cells, end-stage post germinal center B cells, which shows a variable clinical spectrum from asymptomatic to aggressive; the nature of the disease is generally progressive. Rarely, leukemia arises treated plasma cell myeloma. Acute myeloid leukemia/Myelodysplastic syndrome (AML/MDS) is most common, but rare cases of B lymphoblastic leukemia/lymphoma (B-ALL) have been described. The diagnosis of transformation or secondary B-ALL is supported by ancillary studies such as flow cytometry, immunohistochemistry, and molecular studies. Once the diagnosis of a B-ALL is made, consideration should is given as to whether the malignancy is a clonally related transformation of the original PCM or treatment related second leukemia. We present a case of B-ALL after PCM which does not appear to show a clonal relationship with the original PCM suggesting a treatment related B-ALL