Working-Class Standards of Living in Late-Victorian Urban Ontario: A Review of the Miscellaneous Evidence on the Quality of Material Life

Owing to the lack of long series of data pertaining to wages and retail prices, the analysis of standards of living in late-Victorian Ontario presents unusually difficult problems for the social historian. Following the model adopted by the participants in the earlier British standard-of-living debate, this study attempts to mitigate those difficulties, to some extent, by examining a wide range of miscellaneous sociological and economic evidence generated by government agencies, usually for other purposes. A review of the data pertaining to employment, wages, savings, consumption, the accumulation of real wealth, public health and social pathology in urban Ontario between 1875 and 1900 suggests that the 1880s was a decade of rising expectations in terms of employment, consumption, savings and the distribution of wealth following the social and economic upheaval associated with the depression of the late 1870s. However, the evidence also suggests that the marginal gains made in working-class standards of living in the 1880s were largely compromised in the 1890s as the environmental effects of industrialization and urbanization began to be experienced in full measure.En l'absence de séries complètes de statistiques sur les salaires et les prix de vente au détail, l'analyse du mode de vie à la fin du XIXe siècle en Ontario pose de sérieuses difficultés aux spécialistes de l'histoire sociale. En suivant le modèle adopté par les participants à un débat précédent sur le mode de vie en Angleterre, cette étude tente, jusqu'à un certain point, de pallier ces difficultés en examinant une vaste gamme de données socio-économiques obtenues généralement à d'autres fins, par les organismes gouvernementaux. Un examen des données sur l'emploi, les salaires, l'épargne, la consommation, l’enrichissement, la santé publique et l’état pathologique de la société urbaine en Ontario de 1875 à 1900, permet de croire que la décennie 1880 en fut une d'espoirs croissants en termes d'emploi, de consommation, d'épargne et de distribution de la richesse, suite aux bouleversements sociaux et économiques provoqués par la crise économique de la fin des années 1870. Les renseignements laissent cependant croire que l’amélioration du mode de vie de la classe ouvrière obtenue dans les années 1880 fut largement remise en question dans les années 1890, tandis que celle-ci subissait de plein fouet les conséquences environnementales de l'industrialisation et de l'urbanisation

Climatology, storm morphologies, and environments of tornadoes in the British Isles: 1980–2012

A climatology is developed for tornadoes during 1980–2012 in the British Isles, defined in this article as England, Scotland, Wales, Northern Ireland, Republic of Ireland, Channel Islands, and the Isle of Man. The climatology includes parent storm type, interannual variability, annual and diurnal cycles, intensities, oc- currence of outbreaks (defined as three or more tornadoes in the same day), geographic distribution, and environmental conditions derived from proximity soundings of tornadoes. Tornado reports are from the Tornado and Storm Research Organization (TORRO). Over the 33 years, there were a mean of 34.3 tor- nadoes and 19.5 tornado days (number of days in which at least one tornado occurred) annually. Tornadoes and tornado outbreaks were most commonly produced from linear storms, defined as radar signatures at least 75 km long and approximately 3 times as long as wide. Most (78%) tornadoes occurred in England. The probability of a tornado within 10 km of a point was highest in the south, southeast, and west of England. On average, there were 2.5 tornado outbreaks every year. Where intensity was known, 95% of tornadoes were classified as F0 or F1 with the remainder classified as F2. There were no tornadoes rated F3 or greater during this time period. Tornadoes occurred throughout the year with a maximum from May through October. Finally, tornadoes tended to occur in low-CAPE, high-shear environments. Tornadoes in the British Isles were difficult to predict using only sounding-derived parameters because there were no clear thresholds between null, tornadic, outbreak, and significant tornado cases

Farnesoid X Receptor and its ligands inhibit the function of platelets

Objective - While initially seemingly paradoxical due to the lack of nucleus, platelets possess a number of transcription factors that regulate their function through DNA-independent mechanisms. These include the Farnesoid X Receptor (FXR), a member of the superfamily of ligand-activated transcription factors that has been identified as a bile acid receptor. In this study, we show that FXR is present in human platelets and FXR ligands, GW4064 and 6-ECDCA, modulate platelet activation nongenomically. Approach and Results - FXR ligands inhibited the activation of platelets in response to stimulation of collagen or thrombin receptors, resulting in diminished intracellular calcium mobilization and secretion, fibrinogen binding and aggregation. Exposure to FXR ligands also reduced integrin alphaIIbbeta3 outside-in signaling and thereby reduced the ability of platelets to spread and to stimulate clot retraction. FXR function in platelets was found to be associated with the modulation of cGMP levels in platelets and associated downstream inhibitory signaling. Platelets from FXR-deficient mice were refractory to the actions of FXR agonists on platelet function and cyclic nucleotide signaling, firmly linking the non-genomic actions of these ligands to the FXR receptor. Conclusion – This study provides support for the ability of FXR ligands to modulate platelet activation. The athero-protective effects of GW4064, with its novel antiplatelet effects, indicate FXR as a potential target for prevention of athero-thrombotic disease

Interlaboratory study for coral Sr/Ca and other element/Ca ratio measurements

The Sr/Ca ratio of coral aragonite is used to reconstruct past sea surface temperature (SST). Twentyone laboratories took part in an interlaboratory study of coral Sr/Ca measurements. Results show interlaboratory bias can be significant, and in the extreme case could result in a range in SST estimates of 7°C. However, most of the data fall within a narrower range and the Porites coral reference material JCp- 1 is now characterized well enough to have a certified Sr/Ca value of 8.838 mmol/mol with an expanded uncertainty of 0.089 mmol/mol following International Association of Geoanalysts (IAG) guidelines. This uncertainty, at the 95% confidence level, equates to 1.5°C for SST estimates using Porites, so is approaching fitness for purpose. The comparable median within laboratory error is <0.5°C. This difference in uncertainties illustrates the interlaboratory bias component that should be reduced through the use of reference materials like the JCp-1. There are many potential sources contributing to biases in comparative methods but traces of Sr in Ca standards and uncertainties in reference solution composition can account for half of the combined uncertainty. Consensus values that fulfil the requirements to be certified values were also obtained for Mg/Ca in JCp-1 and for Sr/Ca and Mg/Ca ratios in the JCt-1 giant clam reference material. Reference values with variable fitness for purpose have also been obtained for Li/Ca, B/Ca, Ba/Ca, and U/Ca in both reference materials. In future, studies reporting coral element/Ca data should also report the average value obtained for a reference material such as the JCp-1