Riduzionismo e neuroscienze: il dibattito filosofico recente

The purpose of this essay is to investigate how scholars considered the relationship between philosophy and neuroscience, by focusing both on a general point of view, and on the theme of consciousness. It then analyzes the thought of John Bickle, Patricia Churchland and Jesse Prinz with regard to their defence of the reductionist approach on one side and, on the other, that of Max Bennett, Peter Hacker and Alva Noë. This essay also aims at criticizing the claims of neuroscientific philosophers to dissolve the philosophical discourse by pointing out some key issues which are part and parcel of philosophy

Management and communication of archaeological artefacts and architectural heritage using digital IS. What today? What next?

In this paper, we reviewed 20 years of development of 3D based IS to support archaeological and AH artefact knowledge, management and communication and their theoretical work basis. In detail, we illustrated our experiences showing the advantages and limits we had observed after extensive use. In conclusion, we have illustrated a new paradigm based on IoT-related technologies, potentially able to overcome existing problems, and the theoretical foundation of the new framework that has been designed, the concept of the Smart Cultural Object, sources and recipients of advanced information and related technological underpinning

Construction, Management and Visualization of 3D Models of Large Archeological and Architectural Sites for E-Heritage GIS Systems

In this paper we present an integrated system developed in order to record, construct, pre-process, manage, visualize and visually navigate 3D models reality based of large archeological and architectural sites for eHeritage GIS systems. The framework integrates structured geometrical and documentary information resulting from multiple sources with the aim to enhance the knowledge of those sites within the frame of its historical evolution and its institutional management in a 3D GIS/DB. The developed applications were designed for different types of users, with a largely scalable interface, able to support different output devices and to work at different levels of iconicity. The system allows a full comprehension of the buildings in their own context, permitting to discover unknown relationships, to evaluate their architectural occupancy and to quickly access a complex system of information. The framework has been tested in two different systems - designed and developed to satisfy both internal (cataloguing, documentation, preservation, management of archaeological heritage) and external (communication through the web portal) purposes: the first, in Pompeii, developed in order to have a web-based system that uses Open Source software and complies with national and international standards; the second one, a prototype designed to make available on the Google Earth platform the complete Palladian corpus documentation implemented by the CISAAP

A Political Economy? Some Preliminary Thoughts on Economic Privileges in Early Modern Venice

The paper provides a general view of different typologies of privilege existing in the Republic of Venice from 1500 to 1800, connecting together the results of previous research on the subject to build a more complex view of the Venetian “political economy”. The focus on the Venetian case is justified by its alleged exceptionality, which challenges both the usual assumptions about the operation of economic and political privileges, and the general interpretations of their historical evolution. Yet Venice is here used as a laboratory in which historians could elaborate new questions and concepts useful in the investigation of privileges in pre-industrial economies. In this perspective, the authors deal with 1) fair and export privileges of subject cities, their origin and adaptation from the Renaissance up to the fall of the Republic; 2) the role of commercial privileges and how they were used by central authority in order to allow business cooperation, market integration and industrial development; 3) the functions that industrial privileges performed as tools of the Venetian mercantilist policy in order to foster import-substituting and export activities

Links between particle surface hardening and rehydration impairment during micellar casein powder storage

Storage is an unavoidable critical phase regarding dairy powder reconstitution abilities, particularly for high casein content powders, which generally present a poor rehydration behavior. The ability of micellar casein powders to completely rehydrate can thus be particularly affected by storage time and temperature. To implement best practices for the optimization of storage conditions, understanding changes occurring is a crucial point. For the first time, biophysical techniques were used to investigate powder surface at the nanoscale. Atomic force microscopy revealed that particle surface became rougher during storage, associated with the formation of hollow zones (around 500 nm) holes when stored for 10 months at 40 °C. Mechanical properties of micellar casein particle surface during powder storage was quantified using AFM nanoindentation. Spatially-resolved force/indentation curves evidenced a significant stiffer surface for aged powder (Young modulus of ∼20 GPa) in comparison with the fresh one (∼0.2 GPa). These findings were fully consistent with the formation of a crust at the powder surface observed by high-resolution field-emission scanning electron microscopy during powder rehydration. Finally, alterations of the rehydration process can be related to modifications occurring at the particle surface during storage

Diffuse liver disease classification from ultrasound surface characterization, clinical and laboratorial data

In this work liver contour is semi-automatically segmented and quantified in order to help the identification and diagnosis of diffuse liver disease. The features extracted from the liver contour are jointly used with clinical and laboratorial data in the staging process. The classification results of a support vector machine, a Bayesian and a k-nearest neighbor classifier are compared. A population of 88 patients at five different stages of diffuse liver disease and a leave-one-out cross-validation strategy are used in the classification process. The best results are obtained using the k-nearest neighbor classifier, with an overall accuracy of 80.68%. The good performance of the proposed method shows a reliable indicator that can improve the information in the staging of diffuse liver disease

LytR-CpsA-Psr proteins in Staphylococcus aureus display partial functional redundancy and the deletion of all three severely impairs septum placement and cell separation

Staphylococcus aureus contains three members of the LytR-CpsA-Psr (LCP) family of membrane proteins: MsrR, SA0908 and SA2103. The characterization of single-, double- and triple-deletion mutants revealed distinct phenotypes for each of the three proteins. MsrR was involved in cell separation and septum formation and influenced β-lactam resistance; SA0908 protected cells from autolysis; and SA2103, although displaying no apparent phenotype by itself, enhanced the properties of msrR and sa0908 mutants when deleted. The deletion of sa0908 and sa2103 also further attenuated the virulence of msrR mutants in a nematode-killing assay. The severely defective growth phenotype of the triple mutant revealed that LytR-CpsA-Psr proteins are essential for optimal cell division in S. aureus. Growth could be rescued to varying degrees by any one of the three proteins, indicating some functional redundancy within members of this protein family. However, differing phenotypic characteristics of all single and double mutants and complemented triple mutants indicated that each protein played a distinct role(s) and contributed differently to phenotypes influencing cell separation, autolysis, cell surface properties and virulenc

Non-neural phenotype of spinal and bulbar muscular atrophy: Results from a large cohort of Italian patients

Objective: To carry out a deep characterisation of the main androgen-responsive tissues involved in spinal and bulbar muscular atrophy (SBMA). Methods: 73 consecutive Italian patients underwent a full clinical protocol including biochemical and hormonal analyses, genitourinary examination, bone metabolism and densitometry, cardiological evaluation and muscle pathology. Results: Creatine kinase levels were slightly to markedly elevated in almost all cases (68 of the 73; 94%). 30 (41%) patients had fasting glucose above the reference limit, and many patients had total cholesterol (40; 54.7%), low-density lipoproteins cholesterol (29; 39.7%) and triglyceride (35; 48%) levels above the recommended values. Although testosterone, luteinising hormone and follicle-stimulating hormone values were generally normal, in one-third of cases we calculated an increased Androgen Sensitivity Index reflecting the presence of androgen resistance in these patients. According to the International Prostate Symptom Score (IPSS), 7/70 (10%) patients reported severe lower urinal tract symptoms (IPSS score >19), and 21/73 (30%) patients were moderately symptomatic (IPSS score from 8 to 19). In addition, 3 patients were carriers of an indwelling bladder catheter. Videourodynamic evaluation indicated that 4 of the 7 patients reporting severe urinary symptoms had an overt prostate-unrelated bladder outlet obstruction. Dual-energy X-ray absorptiometry scan data were consistent with low bone mass in 25/61 (41%) patients. Low bone mass was more frequent at the femoral than at the lumbar level. Skeletal muscle biopsy was carried out in 20 patients and myogenic changes in addition to the neurogenic atrophy were mostly observed. Conclusions: Our study provides evidence of a wide non-neural clinical phenotype in SBMA, suggesting the need for comprehensive multidisciplinary protocols for these patients. \ua9 2016 Published by the BMJ Publishing Group Limited