Visions and Challenges in Managing and Preserving Data to Measure Quality of Life

Health-related data analysis plays an important role in self-knowledge, disease prevention, diagnosis, and quality of life assessment. With the advent of data-driven solutions, a myriad of apps and Internet of Things (IoT) devices (wearables, home-medical sensors, etc) facilitates data collection and provide cloud storage with a central administration. More recently, blockchain and other distributed ledgers became available as alternative storage options based on decentralised organisation systems. We bring attention to the human data bleeding problem and argue that neither centralised nor decentralised system organisations are a magic bullet for data-driven innovation if individual, community and societal values are ignored. The motivation for this position paper is to elaborate on strategies to protect privacy as well as to encourage data sharing and support open data without requiring a complex access protocol for researchers. Our main contribution is to outline the design of a self-regulated Open Health Archive (OHA) system with focus on quality of life (QoL) data.Comment: DSS 2018: Data-Driven Self-Regulating System

Quantum dot-based multiphoton fluorescent pipettes for targeted neuronal electrophysiology

Targeting visually identified neurons for electrophysiological recording is a fundamental neuroscience technique; however, its potential is hampered by poor visualization of pipette tips in deep brain tissue. We describe quantum dot-coated glass pipettes that provide strong two-photon contrast at deeper penetration depths than those achievable with current methods. We demonstrated the pipettes' utility in targeted patch-clamp recording experiments and single-cell electroporation of identified rat and mouse neurons in vitro and in vivo

Experiences of Healing with Ayahuasca in the United States

Ayahuasca is a psychedelic brew originating from the Amazon in South America. Commonly associated with religious use among indigenous and mestizo populations, ayahuasca has made its way to the United States, where it is currently criminalized as a Schedule I drug. Nevertheless, a church in the United States provides ayahuasca to its members as both a sacrament and tool for healing through spiritual retreat weekends. Based on participant observation and semi-structured interviews with church members, volunteers, and staff in 2023, this thesis examines how members perceived the healing they experienced during multiple ayahuasca ceremonies and interactions with church volunteers and staff. By examining their personal experiences and the extra-drug variables of set and setting, I argue that members received guidance about the next steps in life from the ayahuasca experience itself and from the post-ceremony integration process led by the church. Members often saw this guidance as a path toward mental healing. In addition, members’ ayahuasca experiences were influenced by their intentions for drinking the brew and the overall supportive setting provided by volunteers and staff members. This thesis contributes to the growing body of literature on the renewed interest in psychedelic use for therapeutic purposes in the global north by analyzing ayahuasca use in the unique setting of a spiritual retreat in the United States

Una versión inédita de los Sonets en Llahor del Nom de la gloriosa Verge Maria de Bartolomeo Gentile Fallamonica

En este trabajo se presenta una reflexión inédita sobre la cultura renacentista en Valencia durante los siglos XV y XVI. Para ello, se estudia la historia textual de tres sonetos en vulgar italiano que aparecieron por primera vez en la segunda edición del Cancionero General de Hernando del Castillo (Valencia, 1514) y que, posteriormente, fueron fijados en su versión definitiva por el autor, Bartolomeo Gentile Fallamonica, introduciendo importantes mejorías tanto léxicas como estilísticas

Relazioni linguistico-letterarie tra Genova e la Spagna: aspetti fraseologici

By retracing the historical stages of the relations between Liguria and Spain since the MiddleAges, the article outlines, through a series of examples, some considerations on the phraseology of Spanish and Genoese. A promising panorama of perspectives on the history of linguistic relations between Genoa and Spanish-speaking countries emerges out ofthe analysi

Attenuation of ischemic liver injury by augmentation of endogenous adenosine

Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle dogs underwent 2-hr hepatic vascular exclusion with venovenous bypass. R75231 was given to the animals by continuous intravenous infusion for 30 min before ischemia at a dose of 0.1 mg/kg (Group 2, n=6), 0.05 mg/kg (Group 3, n=6), or 0.025 mg/kg (Group 4, n=6). Nontreated animals were used as the control (Group 1, n= 10). Animal survival, hepatic tissue blood flow, liver function, and histopathology were analyzed. Two- week animal survival was 30% in Group 1, 83% in Group 2, 100% in Group 3, and 100% in Group 4. Postreperfusion hepatic tissue blood flow was markedly improved by the treatment. Treatment significantly attenuated liver enzyme release, lipid peroxidation, and changes in adenine nucleotides and purine catabolites. Structural abnormality of the liver after reperfusion was markedly improved by R75231 treatment, showing better architecture and less neutrophil infiltration. Preischemic administration of a nucleoside transport inhibitor ameliorated ischemic liver injury due to the positive effects of augmented endogenous adenosine, and is applicable clinically when the liver is procured from a controlled non-heartbeating donor

F3B: A Low-Overhead Blockchain Architecture with Per-Transaction Front-Running Protection

Front-running attacks, which benefit from advanced knowledge of pending transactions, have proliferated in the blockchain space since the emergence of decentralized finance. Front-running causes devastating losses to honest participants and continues to endanger the fairness of the ecosystem. We present Flash Freezing Flash Boys (F3B), a blockchain architecture that addresses front-running attacks by using threshold cryptography. In F3B, a user generates a symmetric key to encrypt their transaction, and once the underlying consensus layer has finalized the transaction, a decentralized secret-management committee reveals this key. F3B mitigates front-running attacks because, before the consensus group finalizes it, an adversary can no longer read the content of a transaction, thus preventing the adversary from benefiting from advanced knowledge of pending transactions. Unlike other mitigation systems, F3B properly ensures that all unfinalized transactions, even with significant delays, remain private by adopting per-transaction protection. Furthermore, F3B addresses front-running at the execution layer; thus, our solution is agnostic to the underlying consensus algorithm and compatible with existing smart contracts. We evaluated F3B on Ethereum with a modified execution layer and found only a negligible (0.026%) increase in transaction latency, specifically due to running threshold decryption with a 128-member secret-management committee after a transaction is finalized; this indicates that F3B is both practical and low-cost

QuePaxa: Escaping the tyranny of timeouts in consensus

Leader-based consensus algorithms are fast and efficient under normal conditions, but lack robustness to adverse conditions due to their reliance on timeouts for liveness. We present QuePaxa, the first protocol offering state-of-the-art normal-case efficiency without depending on timeouts. QuePaxa uses a novel randomized asynchronous consensus core to tolerate adverse conditions such as denial-of-service (DoS) attacks, while a one-round-trip fast path preserves the normal-case efficiency of Multi-Paxos or Raft. By allowing simultaneous proposers without destructive interference, and using short hedging delays instead of conservative timeouts to limit redundant effort, QuePaxa permits rapid recovery after leader failure without risking costly view changes due to false timeouts. By treating leader choice and hedging delay as a multi-armed-bandit optimization, QuePaxa achieves responsiveness to prevalent conditions, and can choose the best leader even if the current one has not failed. Experiments with a prototype confirm that QuePaxa achieves normal-case LAN and WAN performance of 584k and 250k cmd/sec in throughput, respectively, comparable to Multi-Paxos. Under conditions such as DoS attacks, misconfigurations, or slow leaders that severely impact existing protocols, we find that QuePaxa remains live with median latency under 380ms in WAN experiments