Testing the theory of immune selection in cancers that break the rules of transplantation

Modification of cancer cells likely to reduce their immunogenicity, including loss or down-regulation of MHC molecules, is now well documented and has become the main support for the concept of immune surveillance. The evidence that these modifications, in fact, result from selection by the immune system is less clear, since the possibility that they may result from reorganized metabolism associated with proliferation or from cell de-differentiation remains. Here, we (a) survey old and new transplantation experiments that test the possibility of selection and (b) survey how transmissible tumours of dogs and Tasmanian devils provide naturally evolved tests of immune surveillance

Computational capabilities at the edge of chaos for one dimensional system undergoing continuous transitions

While there has been a keen interest in studying computation at the edge of chaos for dynamical systems undergoing a phase transition, this has come under question for cellular automata. We show that for continuously deformed cellular automata there is an enhancement of computation capabilities as the system moves towards cellular automata with chaotic spatiotemporal behavior. The computation capabilities are followed by looking into the Shannon entropy rate and the excess entropy, which allows identifying the balance between unpredictability and complexity. Enhanced computation power shows as an increase of excess entropy while the system entropy density has a sudden jump to values near one. The analysis is extended to a system of non-linear locally coupled oscillators that have been reported to exhibit spatiotemporal diagrams similar to cellular automata.Comment: Accepted in CHAO

Contribution to a Circular Economy Model: From LignocellulosicWastes from the Extraction of Vegetable Oils to the Development of a New Composite

[EN] The present works focuses on the development of a novel fully bio-based composite using a bio-based high-density polyethylene (Bio-HDPE) obtained from sugar cane as matrix and a by-product of extraction of chia seed oil (CO) as filler, with the objective of achieving a circular economy model. The research aims to revalorize an ever-increasing waste stream produced by the growing interest in vegetable oils. From the technical point of view, the chia seed flour (CSF) was chemically modified using a silane treatment. This treatment provides a better interfacial adhesion as was evidenced by the mechanical and thermal properties as well as field emission scanning electron microscopy (FESEM). The effect of silane treatment on water uptake and disintegration rate was also studied. On the other hand, in a second stage, an optimization of the percentage of treated CSF used as filler was carried out by a complete series of mechanical, thermal, morphological, colour, water absorption and disintegration tests with the aim to evaluate the new composite developed using chia by-products. It is noteworthy as the disintegration rate increased with the addition of CSF filler, which leads to obtain a partially biodegradable wood plastic composite (WPC) and therefore, becoming more environmentally friendly.I. D-C wants to thank Universitat Politecnica de Valencia for his FPI grant (PAID-2019-SP20190013) and Generalitat Valenciana (GVA) for his FPI grant (ACIF/2020/233).Domínguez-Candela, I.; Garcia-Garcia, D.; A. Perez-Nakai; Lerma-Cantó, A.; Lora-García, J.; Fombuena, V. (2021). Contribution to a Circular Economy Model: From LignocellulosicWastes from the Extraction of Vegetable Oils to the Development of a New Composite. Polymers. 13(14):1-26. https://doi.org/10.3390/polym13142269S126131

Autoevaluación de la calidad del servicio educativo en una institución educativa particular, Chiclayo 2017

La presente investigación, parte de la ausencia de un sistema de gestión de calidad en la I.E.P. El Nazareno, así mismo, se diagnosticó la gestión actual mediante las dimensiones del Modelo EFQM de Excelencia, y, esto permitirá mejorar el servicio brindado en términos de valor agregado, en donde, se promueva una planificación propuesta por el directivo en función de las necesidades demandadas por la sociedad. Teniendo como objetivo principal, el determinar el nivel de la calidad del servicio educativo basado en el Modelo EFQM de Excelencia en la I.E.P. El Nazareno. La metodología es de carácter cualitativo-cuantitativo y las técnicas de recolección de datos están basadas en el FODA realizado por el director y promotor, y encuestas a docentes, estudiantes y padres de familia, las cuales fueron validadas por especialistas procedentes de la Universidad Católica Santo Toribio de Mogrovejo. Los resultados obtenidos, muestra que la estructura del modelo se puede adaptar fácilmente en la institución, y, permite realizar estrategias, orientadas a la mejora continua. Se concluye que la institución presenta un nivel medio de calidad, en cuanto al servicio que brinda y se adecua al Modelo EFQM de Excelencia