Boom & gloom in housing markets: the sequel

Housing

Discovering unbounded episodes in sequential data

One basic goal in the analysis of time-series data is to find frequent interesting episodes, i.e, collections of events occurring frequently together in the input sequence. Most widely-known work decide the interestingness of an episode from a fixed user-specified window width or interval, that bounds the subsequent sequential association rules. We present in this paper, a more intuitive definition that allows, in turn, interesting episodes to grow during the mining without any user-specified help. A convenient algorithm to efficiently discover the proposed unbounded episodes is also implemented. Experimental results confirm that our approach results useful and advantageous.Postprint (published version

Geminivirus Rep Protein Interferes with the Plant DNA Methylation Machinery and Modifies the Host Epigenome

The apparent simplicity of viruses hides the complexity of their interactions with their hosts. Viruses are masters at circumventing host defenses and manipulating the cellular environment for their own benefit. The replication of the largest known family of single-stranded DNA viruses, Geminiviridae, is impaired by DNA methylation and Arabidopsis mutants affected in cytosine methylation are hypersusceptible to geminivirus infection. This implies that plants might use methylation as a defense against geminiviruses and that the viral genome is a target for plant DNA methyltransferases. We have found a novel counter-defense strategy used by geminiviruses, that reduces the expression of the plant maintenance DNA methyltransferases, MET1 and CMT3, in both, locally and systemically infected tissues. Furthermore, we demonstrated that the virus-mediated repression of these two maintenance DNA methyltransferases is widely spread among different geminivirus species. Additionally, we identified Rep as the geminiviral protein responsible for the repression of MET1 and CMT3, and another viral protein, C4, as an ancillary player in MET1 downregulation. The presence of Rep, suppresses TGS of an Arabidopsis transgene and of host loci whose expression is strongly controlled by CG methylation. Bisulfite sequencing analyses showed that the expression of Rep caused a substantial reduction in the levels of DNA methylation at CG sites. Our findings suggest that Rep, the only viral protein essential for geminiviral replication, displays TGS suppressor activity through a mechanism distinct from the one thus far described for geminiviruses.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Lending standards in mortgage markets

While the data seem to suggest that lenders did the right thing by tightening standards and increasing denials...the ongoing financial crisis suggests that they did not tighten them enough.Mortgages ; Bank loans

Perturbations in k-inflation

We extend the theory of cosmological perturbations to the case when the ``matter'' Lagrangian is an arbitrary function of the scalar field and its first derivatives. In particular, this extension provides a unified description of known cases such as the usual scalar field and the hydrodynamical perfect fluid. In addition, it applies to the recently proposed k-inflation, which is driven by non-minimal kinetic terms in the Lagrangian. The spectrum of quantum fluctuations for slow-roll and power law k-inflation is calculated. We find, for instance, that the usual ``consistency relation'' between the tensor spectral index and the relative amplitude of scalar and tensor perturbations is modified. Thus, at least in principle, k-inflation is phenomenologically distinguishable from standard inflation.Comment: 12 pages, LaTe

Casimir energy for de Sitter branes in bulk AdS(5)

The vacuum energy for a massless conformally coupled scalar field in a brane world set up, corresponding to de Sitter branes in a bulk anti-de Sitter spacetime, is calculated. We use the Euclidean version of the metric which can be conformally related to a metric similar in form to the Einstein universe (S^4 times R). Employing zeta-function regularisation we evaluate the one-loop effective potential and show that the vacuum energy is zero for the one brane and non-zero for the two brane configuration. We comment on the back-reaction of this Casimir energy and on the inclusion of a mass term or non-conformal coupling.Comment: 6 pages, no figures, references added, typos corrected, to be published in Phys. Lett.