Alcohol Hangover and Multitasking: Effects on Mood, Cognitive Performance, Stress Reactivity, and Perceived Effort

The aim of this study was to examine the effects of hangover on mood, multitasking ability, and psychological stress reactivity to cognitive demand. Using a crossover design and semi-naturalistic methodology, 25 participants attended the laboratory in the morning following a night of (i) alcohol abstinence and (ii) alcohol self-administration during a typical night out (with order counterbalanced across participants). They completed a four-module multitasking framework (MTF, a widely used laboratory stressor) and a battery of questionnaires assessing mood, hangover symptom severity, and previous night’s sleep. The effects of the MTF on mood and perceived workload were also assessed. Participants in the hangover condition reported significantly lower alertness and contentment coupled with a higher mental fatigue and anxiety. Multitasking ability was also significantly impaired in the hangover condition. Completion of the cognitive stressor increased reported levels of mental demand, effort, and frustration, and decreased perceived level of performance. MTF completion did not differentially affect mood. Lastly, participants rated their sleep as significantly worse during the night prior to the hangover compared with the control condition. These findings confirm the negative cognitive and mood effects of hangover on mood. They also demonstrate that hangover is associated with greater perceived effort during task performance

Effects of alcohol intoxication on driving performance, confidence in driving ability, and psychomotor function: a randomized, double-blind, placebo-controlled study

Rationale: Alcohol-induced driving impairment can occur with any departure from a zero-blood alcohol concentration (BAC). Because intoxication is characterised by impaired judgement, drivers under the influence of alcohol may overestimate their capacity to safely operate a vehicle. Objectives: This study examined the effects of alcohol on driving performance, four-choice reaction time (FCRT), and self-rated confidence in driving ability. It specifically focused on alcohol doses equal to commonly enforced legal BAC limits (i.e. 0.05% and 0.08%). Methods: A randomized, double-blind, placebo-controlled design was utilised. Seventeen participants were tested in three conditions: placebo and two alcohol conditions aiming for BACs of 0.05% and 0.08%. Participants underwent a baseline FCRT task and a 1-h simulated highway driving task before completing another FCRT task and rated their confidence in their driving ability. Results: The high and low alcohol dose conditions resulted in a mean BAC of 0.07%, and 0.04%, respectively (n = 17). The high BAC treatment significantly increased standard deviation of lateral position (SDLP) by 4.06 ± 5.21 cm and standard deviation of speed (SDS) by 0.69 ± 0.17 km/h relative to placebo, while confidence in driving ability remained unchanged across treatments. FCRT performance was impaired by the high BAC treatment (all < 0.01), but there we no significant differences between placebo and low BAC conditions. Conclusions: The findings of this study show that driving performance and associated psychomotor functioning become significantly impaired below legally permissible driving limits in some jurisdictions. We identified a dissociation between driving performance and subjective awareness of impairment. Despite a significantly diminished driving ability at 0.07% BAC, drivers were unaware of their impairment

Effects of alcohol hangover on attentional resources during a verbal memory/psychomotor tracking dual attention task

Background: Alcohol hangover (AH) is associated with impaired attention and memory performance. However, whether this effect is related to reduced attentional resources remains unclear. Aims: A dual-attention paradigm was employed to assess the effects of AH on attentional resources, delayed memory recognition, and the interaction between attentional load and AH. Mental effort and perceived performance during AH and control conditions were also assessed. Methods: A seminaturalistic, crossover design was used. In total, 25 healthy social drinkers aged 18–35 years, visited the laboratory following a typical night out drinking (Hangover condition) and after alcohol abstinence (control) between 8:30 am and 12:30 pm, with conditions counterbalanced. Attentional load was manipulated via the presence (dual attention) or absence of psychomotor tracking during verbal memory encoding. Perceived mental effort and performance were measured using the NASA-TLX. Participants’ recollected alcohol consumption was used to compute estimated blood alcohol level (eBAC). Results: Compared with the control visit, AH was associated with reduced recognition accuracy (particularly more false negatives), higher “tracking costs” (poorer accuracy) in the dual attention condition, increased ratings of “mental demand,” “effort,” and “frustration,” and lower ratings of task performance. There was also a significant main effect of attentional load with poorer recognition accuracy and response time in the dual attention condition. There were no significant interaction effects between hangover and attentional load. Conclusion: These findings suggest that reduced attentional resources contribute to the cognitive deficits associated with AH including impaired memory consolidation. They further suggest that while hungover, participants are aware of these deficits but are unable to compensate

Considerations in the search for epistasis

Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive heritability model. However, the search for epistasis has so far largely failed to recover this missing heritability. We identify key challenges and propose that future works need to leverage idealized systems, known biology and even previously identified epistatic interactions, in order to guide the search for new interactions

Violencia Institucional: La toma de control de los municipios por los protestantes en el sur de Francia (1560-1562)

Based on a close and detailed investigation of local and strangely neglected municipal sources, combined with the meticulous scrutiny of documents conserved in the Russian archives for the period 1559-1562, and a focus on institutional history, I demonstrate how the early Calvinistic consistories cleverly manipulated the particular municipal organization (the consulates) of Midi communities and managed to take them over with relative ease. In many of these communities, which greatly varied in size, we find that the consistories were turned into “political councils”; this subsequently enabled them to control the election of magistrates (consuls) and, even before the beginning of the wars of Religion, to ensure that they controlled the municipalities, though the Protestants were very much a minority. This is a major factor towards explaining the famous “Protestant crescent” that characterizes the South of France with its tones of civil religion.Este artículo tiene como objetivo demostrar cómo los consistorios calvinistas, en su primera época, supieron manipular de manera inteligente una forma concreta de organización municipal de los pueblos del sur de Francia, los consulados, lo que les permitió hacerse con el poder municipal con relativa facilidad. Para ello se realiza un análisis minucioso y detallado de fuentes locales que han sido extrañamente marginadas, combinando dicha información con el escrutinio de los documentos conservados en los archivos rusos para el periodo 1559-1562, aplicando una perspectiva de la historia institucional. En muchas de las comunidades analizadas, las cuales varían enormemente en tamaño, encontramos que los consistorios se convirtieron en “consejos políticos”. Esta transformación permitió a la pequeña minoría protestante controlar la elección de magistrados locales (cónsules) y asegurar con ello el control de los municipios antes incluso de que estallaran las guerras de religión. Este factor es fundamental para entender la famosa “medial luna protestante” que se expandió por el sur de Francia y sus discursos de religión cívica

Considerations in the search for epistasis

Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive heritability model. However, the search for epistasis has so far largely failed to recover this missing heritability. We identify key challenges and propose that future works need to leverage idealized systems, known biology and even previously identified epistatic interactions, in order to guide the search for new interactions

Considerations in the search for epistasis

Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible and good candidates to explain observations which are not fully explained by an additive heritability model. However, the search for epistasis has so far largely failed to recover this missing heritability. We identify key challenges and propose that future works need to leverage idealized systems, known biology and even previously identified epistatic interactions, in order to guide the search for new interactions