Магнитокоммутируемая микросхема и датчик измерения скорости ветра на ее основе

Разработанная магнитокоммутируемая микросхема на основе эффекта Холла позволила создать магнитный датчик скорости ветра.У статті представлено опис магн·токомутуємої мікросхе·ми на основі ефекту Холу. Приведені електрична схема розробленої МКМ і її основні технічні характеристики. Розроблено датчик швидкості вітру на її основі. Діапазон вимірювання швидкості вітру склав 0,5 - 50 м/с з похибкою ±5%.The magneto switch microcircuit on the base of Hall-effect is developed. The electric scheme of the magneto sensitive IC was designed and its basic technical characteristics are described. The gauge of wind speed on its base is fabricated

Integrating Information Literacy Across a BSN Curriculum

(41st Biennial Convention) Although research regarding effective informatics teaching strategies is sparse, nurse educators are challenged to include informatics into an already burgeoning curriculum. This presentation offers a systematic approach to incorporating information literacy, a vital component of informatics, across a BSN curriculum. Motivated by the IOM reports, the TIGER competency framework, and the QSEN informatics competencies, five assignments have been developed to emphasize clinical application. The assignments are designed to incrementally: (a) increase students\u27 abilities to recognize the need for information (knowledge); (b) advance students\u27 abilities to locate, evaluate, and use information (skills); and (c) foster a positive appreciation for information literacy (attitudes) in planning safe, effective patient care (Cronenwett, et al., 2007). In the first semester, students are assigned to access and evaluate a current article reflecting safe, client-centered nursing care. During the second and third semesters, the focus is on implementation of information through assignments such as designing a teaching brochure and evaluating a nursing procedure. Assignments during the fourth and fifth semesters focus on the use of health information to support clinical decisions, promote safety, and improve patient care. For one assignment, students work collaboratively in teams to search for relevant information to plan care related to a specific health concern from various perspectives. For the final assignment, students identify examples of how informatics and health care information are used within their respective practice settings to make clinical and organizational decisions

Вплив екологічного стану Донецького регіону на його демографічний розвиток

В статті розглянуто важливу проблему впливу забрудненості навколишнього природного середовища на захворюваність та смертність в регіоні. Визначено кореляційну залежність між обсягом викидів забруднюючих речовин та окремими видами захворюваності, а також ступінь їх впливу, побудовано функції, що описують їх.В статье рассмотрена важная проблема влияния загрязненности окружающей естественной среды на заболеваемость и смертность в регионе. Определена корреляционная зависимость между объемом выбросов загрязняющих веществ и отдельными видами заболеваемости, а также степень их влияния, построены функции, которые описывают их.In the article the important problem of influence of muddiness of natural environment is considered on morbidity and death rate in a region. Certainly cross-correlation dependence between the volume of extrass of contaminents and separate types of morbidity, and also degree of their influence, functions which describe them are built. Keywords: environment

A ligand for the aryl hydrocarbon receptor isolated from lung

Author Posting. © National Academy of Sciences, 2002. This article is posted here by permission of National Academy of Sciences for personal use, not for redistribution. The definitive version was published in Proceedings of the National Academy of Sciences 99 (2002): 14694-14699, doi:10.1073/pnas.232562899.The aryl hydrocarbon receptor (AHR) is a ligand-inducible transcription factor that is best known because it mediates the actions of polycyclic and halogenated aromatic hydrocarbon environmental toxicants such as 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. We report here the successful identification of an endogenous ligand for this receptor; {approx}20 µg was isolated in pure form from 35 kg of porcine lung. Its structure was deduced as 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester from extensive physical measurements and quantum mechanical calculations. In a reporter gene assay, this ligand activates the AHR with a potency five times greater than that of {beta}-naphthoflavone, a prototypical synthetic AHR ligand. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester competes with 2,3,7,8-[3H]tetrachlorodibenzo-p-dioxin for binding to human, murine, and fish AHRs, thus showing that AHR activation is caused by direct receptor binding, and that recognition of this endogenous ligand is conserved from early vertebrates (fish) to humans.This work was supported by the Wisconsin Alumni Research Foundation, the University of Wisconsin Sea Grant Institute, and the National Institutes of Health

The role of the <i>Ah</i> locus in hexachlorobenzene-induced porphyria. Studies in congenic C57BL/6J mice

The role of the Ah locus in hexachlorobenzene (HCB)-induced porphyria and the possible involvement of P-450 cytochromes P(1)450 and P(3)450 in the pathogenesis of this disease were investigated in two congenic strains of C57BL/6J mice that differ only at this locus. Female B6-Ahb mice (Ah receptor: approximately 30-70 fmol/mg of cytosolic protein) and B6-Ahd mice (Ah receptor: undetectable) were pretreated with iron (500 mg/kg) and then fed a diet containing 0 or 200 p.p.m. of HCB for up to 17 weeks. Mice from the two strains consumed similar amounts of HCB. Urinary excretion of porphyrins was increased after 7 weeks of HCB treatment in B6-Ahb mice, and after 15 weeks was over 200 times greater than that of mice given iron only. In B6-Ahd mice, porphyrin excretion did not begin to increase until after 13 weeks, and after 15 weeks was only six times greater than that of controls. Similar differences were seen in the 15-week hepatic porphyrin concentrations (B6-Ahb: 1110 +/- 393; B6-Ahd: 17.6 +/- 14.5; controls: approximately 0.20 nmol/g). Uroporphyrinogen decarboxylase (EC 4.1.1.37) activity was diminished by 70 and 20% in B6-Ahb B6-Ahd mice respectively after 15 weeks of treatment with HCB. Cytochromes P(1)450 and P(3)450 were measured in hepatic microsomes (microsomal fractions) by radioimmunoassay and immunoblotting, using antisera raised against the orthologous rat isoenzymes P450c and P450d. HCB induced small amounts of a protein recognized by anti-P450c (P(1)450) in B6-Ahd mice, but not in B6-Ahd mice. Relatively large amounts of a protein recognized by anti-P450d (P(3)450) were induced in both strains, but to a somewhat greater extent in the B6-Ahb mice. The hepatic accumulation of HCB at 15 weeks was greater in B6-Ahb than in B6-Ahd mice, in association with elevated hepatic lipid levels in the former strain. The results of this experiment indicate that the Ah locus influences the susceptibility of C57BL/6J mice to HCB-induced porphyria and are consistent with the suggestion that the sustained induction of P(3)450 and/or P(1)450 may be a causative factor in the development of this disease.</jats:p

Aryl Hydrocarbon Receptor Deficiency in an Exon 3 Deletion Mouse Model Promotes Hematopoietic Stem Cell Proliferation and Impacts Endosteal Niche Cells

The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor belonging to the Per-Arnt-Sim (PAS) family of proteins. The AHR is involved in hematopoietic stem cell (HSC) functions including self-renewal, proliferation, quiescence, and differentiation. We hypothesize that AHR impacts HSC functions by influencing genes that have roles in HSC maintenance and function and that this may occur through regulation of bone marrow (BM) niche cells. We examined BM and niche cells harvested from 8-week-old AHR null-allele (KO) mice in which exon 3 was deleted in the Ahr gene and compared these data to cells from B6 control mice; young and old (10 months) animals were also compared. We report changes in HSCs and peripheral blood cells in mice lacking AHR. Serial transplantation assays revealed a significant increase in long term HSCs. There was a significant increase in mesenchymal stem cells constituting the endosteal BM niche. Gene expression analyses of HSCs revealed an increase in expression of genes involved in proliferation and maintenance of quiescence. Our studies infer that loss of AHR results in increased proliferation and self-renewal of long term HSCs, in part, by influencing the microenvironment in the niche regulating the balance between quiescence and proliferation in HSCs