Complementary Speckle Patterns : deterministic interchange of intrinsic vortices and maxima through Scattering Media

Intensity minima and maxima of speckle patterns obtained behind a diffuser are experimentally interchanged by applying a spiral phase delay of charge $\pm 1$ to the impinging coherent beam. This transform arises from the intuitive expectation that a tightly focused beam is so-changed into a vortex beam and vice-versa. The statistics of extrema locations and the intensity distribution of the so-generated "complementary" patterns are characterized by numerical simulations. It is demonstrated experimentally that the incoherent superposition of the three "complementary speckle patterns" yield a synthetic speckle grain size enlarged by a factor $\sqrt{3}$. A cyclic permutation of optical vortices and maxima is unexpectedly observed and discussed.Comment: 9 pages, 9 figure

Light Focusing and Two-Dimensional Imaging Through Scattering Media using the Photoacoustic Transmission-Matrix with an Ultrasound Array

We implement the photoacoustic transmission-matrix approach on a two-dimensional photoacoustic imaging system, using a 15 MHz linear ultrasound array. Using a black leaf skeleton as a complex absorbing structure, we demonstrate that the photoacoustic transmission-matrix approach allows to reveal structural features that are invisible in conventional photoacoustic images, as well as to selectively control light focusing on absorbing targets, leading to a local enhancement of the photoacoustic signal

Improving Photoacoustic-guided Focusing in Scattering Media by Spectrally Filtered Detection

We experimentally and numerically study the potential of photoacoustic-guiding for light focusing through scattering samples via wavefront-shaping and iterative optimization. We experimentally demonstrate that the focusing efficiency on an extended absorber can be improved by iterative optimization of the high frequency components of the broadband photoacoustic signal detected with a spherically focused transducer. We demonstrate more than 8-fold increase in the photoacoustic signal generated by a 30 microns wire using a narrow frequency band around 60MHz. We numerically confirm that such optimization leads to a smaller optical focus than using the low frequency content of the photoacoustic feedback

Essais précoces en cancérologie, éthique et justice

National audienceC'est dans le cadre d'un programme de recherche sur l'égalité d'accès aux essais cliniques de cancérologie ("EgaliCan") que le symposium "Essais précoces en cancérologie : quelles définitions, quelle justice ?" s'est tenu au Collège de France le 24 mai dernier 2012. Ce symposium avait pour objet de contribuer à la réflexion sur la définition des essais précoces en cancérologie et sur les questions nouvelles de justice et d'éthique qu'ils posent

Topological transformations of speckles

Deterministic control of coherent random light is highly important for information transmission through complex media. However, only a few simple speckle transformations can be achieved through diffusers without prior characterization. As recently shown, spiral wavefront modulation of the impinging beam allows permuting intensity maxima and intrinsic $\pm 1$-charged optical vortices. Here, we study this cyclic-group algebra when combining spiral phase transforms of charge $n$, with $D_3$- and $D_4$-point-group symmetry star-like amplitude modulations. This combination allows statistical strengthening of permutations and controlling the period to be 3 and 4, respectively. Phase saddle-points are shown to complete the cycle. These results offer new tools to manipulate critical points in speckles.Comment: 14 pages, 10 figures, 4 table

Super-resolution photoacoustic fluctuation imaging with multiple speckle illumination

In deep tissue photoacoustic imaging, the spatial resolution is inherently limited by acoustic diffraction. Moreover, as the ultrasound attenuation increases with frequency, resolution is often traded-off for penetration depth. Here we report on super-resolution photoacoustic imaging by use of multiple speckle illumination. Specifically, we show that the analysis of second-order fluctuations of the photoacoustic images combined with image deconvolution enables resolving optically absorbing structures beyond the acoustic diffraction limit. A resolution increase of almost a factor 2 is demonstrated experimentally. Our method introduces a new framework that could potentially lead to deep tissue photoacoustic imaging with sub-acoustic resolution

In silico vs. Over the Clouds: On-the-Fly Mental State Estimation of Aircraft Pilots, Using a Functional Near Infrared Spectroscopy Based Passive-BCI

There is growing interest for implementing tools to monitor cognitive performance in naturalistic work and everyday life settings. The emerging field of research, known as neuroergonomics, promotes the use of wearable and portable brain monitoring sensors such as functional near infrared spectroscopy (fNIRS) to investigate cortical activity in a variety of human tasks out of the laboratory. The objective of this study was to implement an on-line passive fNIRS-based brain computer interface to discriminate two levels of working memory load during highly ecological aircraft piloting tasks. Twenty eight recruited pilots were equally split into two groups (flight simulator vs. real aircraft). In both cases, identical approaches and experimental stimuli were used (serial memorization task, consisting in repeating series of pre-recorded air traffic control instructions, easy vs. hard). The results show pilots in the real flight condition committed more errors and had higher anterior prefrontal cortex activation than pilots in the simulator, when completing cognitively demanding tasks. Nevertheless, evaluation of single trial working memory load classification showed high accuracy (>76%) across both experimental conditions. The contributions here are two-fold. First, we demonstrate the feasibility of passively monitoring cognitive load in a realistic and complex situation (live piloting of an aircraft). In addition, the differences in performance and brain activity between the two experimental conditions underscore the need for ecologically-valid investigations

Pré-dimensionnement de convertisseur de très forte puissance pour une application à la propulsion aéronautique hybride

Dans le cadre de l’étude sur l’intérêt de l’hybridation électrique de la propulsion des futurs aéronefs, le travail réalisé consiste à proposer des structures de conversion de puissance et à pré-dimensionner une chaîne électrique forte puissance intégrant un bus continu haute tension, son câblage et l’électronique de puissance interfaçant le bus et la motorisation électrique. La première étape de cette étude consiste à déterminer la tension du bus DC en prenant en compte la problématique des décharges partielles qui limite la possibilité de l’augmentation du niveau de tension au niveau des conducteurs placés en zone non pressurisée. Pour choisir une plage de tension optimale, il est nécessaire d’étudier le rendement de plusieurs topologies multiniveaux mais cela est rendu difficile par la discrétisation des calibres en tension disponibles sur le marché des semi-conducteurs de puissance. Pour pallier à ce problème, une base de données de composants continue qui s’adapte à la tension de calibre souhaitée est créée en extrapolant les familles de composants existants

Optical-resolution photoacoustic imaging through thick tissue with a thin capillary as a dual optical-in acoustic-out waveguide

We demonstrate the ability to guide high-frequency photoacoustic waves through thick tissue with a water-filled silica-capillary (150 \mu m inner diameter and 30 mm long). An optical-resolution photoacoustic image of a 30 \mu m diameter absorbing nylon thread was obtained by guiding the acoustic waves in the capillary through a 3 cm thick fat layer. The transmission loss through the capillary was about -20 dB, much lower than the -120 dB acoustic attenuation through the fat layer. The overwhelming acoustic attenuation of high-frequency acoustic waves by biological tissue can therefore be avoided by the use of a small footprint capillary acoustic waveguide for remote detection. We finally demonstrate that the capillary can be used as a dual optical-in acoustic-out waveguide, paving the way for the development of minimally invasive optical-resolution photoacoustic endoscopes free of any acoustic or optical elements at their imaging tip

Real-Time State Estimation in a Flight Simulator Using fNIRS

Working memory is a key executive function for flying an aircraft. This function is particularly critical when pilots have to recall series of air traffic control instructions. However, working memory limitations may jeopardize flight safety. Since the functional near-infrared spectroscopy (fNIRS) method seems promising for assessing working memory load, our objective is to implement an on-line fNIRS-based inference system that integrates two complementary estimators. The first estimator is a real-time state estimation MACD-based algorithm dedicated to identifying the pilot’s instantaneous mental state (not-on-task vs. on-task). It does not require a calibration process to perform its estimation. The second estimator is an on-line SVM-based classifier that is able to discriminate task difficulty (low working memory load vs. high working memory load). These two estimators were tested with 19 pilots who were placed in a realistic flight simulator and were asked to recall air traffic control instructions. We found that the estimated pilot’s mental state matched significantly better than chance with the pilot’s real state (62% global accuracy, 58% specificity, and 72% sensitivity). The second estimator, dedicated to assessing single trial working memory loads, led to 80% classification accuracy, 72% specificity, and 89% sensitivity. These two estimators establish reusable blocks for further fNIRS-based passive brain computer interface development