Buschke–Lowenstein tumour of glans penis

AbstractINTRODUCTIONBuschke–Löwenstein tumour, also known as Giant condyloma acuminatum, is a rare, sexually transmitted disease that affects ano-genital region. BLT is a slow growing cauliflower-like tumour, locally aggressive and destructive. Human papillomavirus has been identified as an important contributory factor in the development of tumour.PRESENTATION OF CASEA 45 year uncircumcised male presented with complaints of cauliflower like growth on glans penis. Growth started as a small papule on the corona sulcus at 12 O’clock position 6 months back. Patient developed pain and dysuria due to compression of urethral meatus. Patient has history of multiple sexual partners.DISCUSSIONBLT, first described by Buschke and Lowenstein in 1925. They observed a penile lesion that clinically resembled both common condyloma acuminata and squamous cell carcinoma, but differing from both of them regarding the biological behaviour and the histopathological appearance. GCA can be differentiated from ordinary condylomas by the characteristic “pushing” rather than “infiltrating” effect that tends to compress and displace the underlying tissue.CONCLUSIONWe have successfully treated a penile BLT with surgical excision and no relapse up to 6 months. Surgical excision could be considered an effective therapy in the treatment

A review on: Neocov is not new COVID it’s old and similar to SARS

Recently, Coronavirus has given great attention from the biomedical community based on the appearance and isolation coronavirus that infects humans. To understand the new MERS-COV behaviour appears to require different knowledge levels (epidemiologists, antigenic, and pathogens), and this knowledge can be produced from the most related viruses. In this study, we direct to compare between 3 species of Coronavirus, namely Middle Eastern respiratory syndrome (MERS-COV), severe acute respiratory syndrome (SARS-COV), and Neocov regarding all genomes and 6 similar proteins (E, M, N, S, ORF1A, and ORF1AB) use different bioinformatics tools to provide a better understanding of the relationship between 3 viruses at nucleotide and amino acids. All sequences have obtained from the National Center Biotechnology Center (NCBI). Greetings to target genomes phylogenetic analysis shows that MERS and SARS-COV is closer to each other compared to Neocov, and the latter has a relatively longest time. We found that all phylogenetic methods in addition to all parameters (physical and chemical properties of amino acids such as amino acid, molecular weight, atoms the composition, theoretical pi, and structural formula) show that Neocov protein is the most related to MERS-COV. All phylogenetics trees (with the maximum-possibility method and joining neighbours) show that Protein Neocov has less evolution changes except ORF1A only with the maximum possible method. Our results show a high similarity between the structural protein of the virus responsible for the virus infectivity; Therefore, we hope Neocov will appear faster in human-related infections.</jats:p