Statistical dynamics of a non-Abelian anyonic quantum walk

We study the single particle dynamics of a mobile non-Abelian anyon hopping around many pinned anyons on a surface. The dynamics is modelled by a discrete time quantum walk and the spatial degree of freedom of the mobile anyon becomes entangled with the fusion degrees of freedom of the collective system. Each quantum trajectory makes a closed braid on the world lines of the particles establishing a direct connection between statistical dynamics and quantum link invariants. We find that asymptotically a mobile Ising anyon becomes so entangled with its environment that its statistical dynamics reduces to a classical random walk with linear dispersion in contrast to particles with Abelian statistics which have quadratic dispersion.Comment: 7 pages, 5 figure

Recognizing and Curating Photo Albums via Event-Specific Image Importance

Automatic organization of personal photos is a problem with many real world ap- plications, and can be divided into two main tasks: recognizing the event type of the photo collection, and selecting interesting images from the collection. In this paper, we attempt to simultaneously solve both tasks: album-wise event recognition and image- wise importance prediction. We collected an album dataset with both event type labels and image importance labels, refined from an existing CUFED dataset. We propose a hybrid system consisting of three parts: A siamese network-based event-specific image importance prediction, a Convolutional Neural Network (CNN) that recognizes the event type, and a Long Short-Term Memory (LSTM)-based sequence level event recognizer. We propose an iterative updating procedure for event type and image importance score prediction. We experimentally verified that image importance score prediction and event type recognition can each help the performance of the other.Comment: Accepted as oral in BMVC 201

Approach to Parton Equilibration

Perturbative QCD-based models of parton production and equilibration in ultrarelativistic heavy ion collisions are reviewed with an emphasis on the treatment of quantum interference effects. Uncertainties in the initial parton production and their effects on later parton equilibration are considered. Probes of early parton dynamics are also discussed.Comment: 15 pages in Latex with macro QM95.sty and 8 figures included, Invited talk at Quark Matter'95, Monterey, Jan. 9, 1995

Differential binding patterns of anti-sulfatide antibodies to glial membranes

Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may not represent the diversity of anti-sulfatide antibody binding patterns found in neuropathy patients. We sought to address this issue by generating and characterising a panel of new anti-sulfatide monoclonal antibodies. These antibodies have sulfatide reactivity distinct from existing antibodies in assays and in binding to peripheral nerve tissues and can be used to provide insights into the pathophysiological roles of anti-sulfatide antibodies in demyelinating neuropathies

Heavy Ion Physics at the LHC

The ion-ion center of mass energies at the LHC will exceed that at RHIC by nearly a factor of 30, providing exciting opportunities for addressing unique physics issues in a completely new energy domain. Some highlights of this new physics domain are presented here. We briefly describe how these collisions will provide new insights into the high density, low momentum gluon content of the nucleus expected to dominate the dynamics of the early state of the system. We then discuss how the dense initial state of the nucleus affects the lifetime and temperature of the produced system. Finally, we explain how the high energy domain of the LHC allows abundant production of `rare' processes, hard probes calculable in perturbative quantum chromodynamics, QCD. At the LHC, high momentum jets and $b \bar b$ bound states, the $\Upsilon$ family, will be produced with high statistics for the first time in heavy ion collisions.Comment: 10 pages, 2 figures, proceedings of INPC 04 in Goteborg, Sweden, July 2004, includes conference style fil

Drell-Yan and J/psi Production in High Energy Proton-Nucleus and Nucleus-Nucleus Collisions

The distributions of outgoing protons and charged hadrons in high energy proton-nucleus collisions are described rather well by a linear extrapolation from proton-proton collisions. This linear extrapolation is applied to precisely measured Drell-Yan cross sections for 800 GeV protons incident on a variety of nuclear targets. The deviation from linear scaling in the atomic number A can be accounted for by energy degradation of the proton as it passes through the nucleus if account is taken of the time delay of particle production due to quantum coherence. We infer an average proper coherence time of 0.4 +/- 0.1 fm/c. Then we apply the linear extrapolation to measured J/psi production cross sections for 200 and 450 GeV/c protons incident on a variety of nuclear targets. Our analysis takes into account energy loss of the beam proton, the time delay of particle production due to quantum coherence, and absorption of the J/psi on nucleons. The best representation is obtained for a coherence time of 0.5 fm/c, which is consistent with Drell-Yan production, and an absorption cross section of 3.6 mb, which is consistent with the value deduced from photoproduction of the J/psi on nuclear targets. Finally, we compare to recent J/psi data from S+U and Pb+Pb collisions at the SPS. The former are reproduced reasonably well with no new parameters, but not the latter.Comment: Talks given at Quark Matter '99, the 14th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions, Torino, Italy, May 10-14, 1999. 10 pages, five figure

Focused ultrasound-enabled brain tumor liquid biopsy

Abstract Although blood-based liquid biopsies have emerged as a promising non-invasive method to detect biomarkers in various cancers, limited progress has been made for brain tumors. One major obstacle is the blood-brain barrier (BBB), which hinders efficient passage of tumor biomarkers into the peripheral circulation. The objective of this study was to determine whether FUS in combination with microbubbles can enhance the release of biomarkers from the brain tumor to the blood circulation. Two glioblastoma tumor models (U87 and GL261), developed by intracranial injection of respective enhanced green fluorescent protein (eGFP)-transduced glioblastoma cells, were treated by FUS in the presence of systemically injected microbubbles. Effect of FUS on plasma eGFP mRNA levels was determined using quantitative polymerase chain reaction. eGFP mRNA were only detectable in the FUS-treated U87 mice and undetectable in the untreated U87 mice (maximum cycle number set to 40). This finding was replicated in GL261 mice across three different acoustic pressures. The circulating levels of eGFP mRNA were 1,500–4,800 fold higher in the FUS-treated GL261 mice than that of the untreated mice for the three acoustic pressures. This study demonstrated the feasibility of FUS-enabled brain tumor liquid biopsies in two different murine glioma models across different acoustic pressures

Magnetic form factor of SrFe2_2As2_2

Neutron diffraction measurements have been carried out to investigate the magnetic form factor of the parent SrFe2As2 system of the iron-based superconductors. The general feature is that the form factor is approximately isotropic in wave vector, indicating that multiple d-orbitals of the iron atoms are occupied as expected based on band theory. Inversion of the diffraction data suggests that there is some elongation of the spin density toward the As atoms. We have also extended the diffraction measurements to investigate a possible jump in the c-axis lattice parameter at the structural phase transition, but find no detectable change within the experimental uncertainties

Human cytomegalovirus: taking the strain

In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV), we reflect on the merits and limitations of the viral strains currently being used to develop urgently needed treatments. HCMV research has been dependent for decades on the high-passage strains AD169 and Towne, heavily exploiting their capacity to replicate efficiently in fibroblasts. However, the genetic integrity of these strains is so severely compromised that great caution needs to be exercised when considering their past and future use. It is now evident that wild-type HCMV strains are not readily propagated in vitro. HCMV mutants are rapidly selected during isolation in fibroblasts, reproducibly affecting gene RL13, the UL128 locus (which includes genes UL128, UL130 and UL131A) and often the UL/b′ region. As a result, the virus becomes less cell associated, altered in tropism and less pathogenic. This problem is not restricted to high-passage strains, as even low-passage strains can harbour biologically significant mutations. Cloning and manipulation of the HCMV genome as a bacterial artificial chromosome (BAC) offers a means of working with stable, genetically defined strains. To this end, the low-passage strain Merlin genome was cloned as a BAC and sequentially repaired to match the viral sequence in the original clinical sample from which Merlin was derived. Restoration of UL128L to wild type was detrimental to growth in fibroblasts, whereas restoration of RL13 impaired growth in all cell types tested. Stable propagation of phenotypically wild-type virus could be achieved only by placing both regions under conditional expression. In addition to the development of these tools, the Merlin transcriptome and proteome have been characterized in unparalleled detail. Although Merlin may be representative of the clinical agent, high-throughput whole-genome deep sequencing studies have highlighted the remarkable high level of interstrain variation present in circulating virus. There is a need to develop systems capable of addressing the significance of this diversity, free from the confounding effects of genetic changes associated with in vitro adaptation. The generation of a set of BAC clones, each containing the genome of a different HCMV strain repaired to match the sequence in the clinical sample, would provide a pathway to address the biological and clinical effects of natural variation in wild-type HCMV