Business Analysis Of Salted Fish Processing In Pondok Batu Villages Sarudik Subdistrict Sibolga District North Sumatra Province

The research was conducted on July, 2016 in Pondok Batu Villages, Sarudik Subdistrict, Sibolga District, North Sumatra Province. This study was aimed to analyzed the input, process, output in analysis of salted fish processing, determine the investment and profits as well as analyzing the prospects and constraints of salted fish processing business. The research method used was a survey by takeing an activity/case study and determine the respondents using census method.Based on this research, salted fish processing business activities in the form of inputs have sufficient availability, process and output runs regularly so as to produce output in the form of processed products salted fish ready for market. The total investment every month is Rp 76.952 million,- and profits every month is Rp 9.895.083. According to different eligibility criteria, this effort deserves to be continued and developed

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data

Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear. Objective: To clarify whether DCS is superior to placebo in augmenting the effects of cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders and to evaluate whether antidepressants interact with DCS and the effect of potential moderating variables. Data Sources: PubMed, EMBASE, and PsycINFO were searched from inception to February 10, 2016. Reference lists of previous reviews and meta-analyses and reports of randomized clinical trials were also checked. Study Selection: Studies were eligible for inclusion if they were (1) double-blind randomized clinical trials of DCS as an augmentation strategy for exposure-based cognitive behavior therapy and (2) conducted in humans diagnosed as having specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-compulsive disorder, or posttraumatic stress disorder. Data Extraction and Synthesis: Raw data were obtained from the authors and quality controlled. Data were ranked to ensure a consistent metric across studies (score range, 0-100). We used a 3-level multilevel model nesting repeated measures of outcomes within participants, who were nested within studies. Results: Individual participant data were obtained for 21 of 22 eligible trials, representing 1047 of 1073 eligible participants. When controlling for antidepressant use, participants receiving DCS showed greater improvement from pretreatment to posttreatment (mean difference, -3.62; 95% CI, -0.81 to -6.43; P = .01; d = -0.25) but not from pretreatment to midtreatment (mean difference, -1.66; 95% CI, -4.92 to 1.60; P = .32; d = -0.14) or from pretreatment to follow-up (mean difference, -2.98, 95% CI, -5.99 to 0.03; P = .05; d = -0.19). Additional analyses showed that participants assigned to DCS were associated with lower symptom severity than those assigned to placebo at posttreatment and at follow-up. Antidepressants did not moderate the effects of DCS. None of the prespecified patient-level or study-level moderators was associated with outcomes. Conclusions and Relevance: D-cycloserine is associated with a small augmentation effect on exposure-based therapy. This effect is not moderated by the concurrent use of antidepressants. Further research is needed to identify patient and/or therapy characteristics associated with DCS response.2018-05-0

Study protocol to investigate the effect of a lifestyle intervention on body weight, psychological health status and risk factors associated with disease recurrence in women recovering from breast cancer treatment

Background Breast cancer survivors often encounter physiological and psychological problems related to their diagnosis and treatment that can influence long-term prognosis. The aim of this research is to investigate the effects of a lifestyle intervention on body weight and psychological well-being in women recovering from breast cancer treatment, and to determine the relationship between changes in these variables and biomarkers associated with disease recurrence and survival. Methods/design Following ethical approval, a total of 100 patients will be randomly assigned to a lifestyle intervention (incorporating dietary energy restriction in conjunction with aerobic exercise training) or normal care control group. Patients randomised to the dietary and exercise intervention will be given individualised healthy eating dietary advice and written information and attend moderate intensity aerobic exercise sessions on three to five days per week for a period of 24 weeks. The aim of this strategy is to induce a steady weight loss of up to 0.5 Kg each week. In addition, the overall quality of the diet will be examined with a view to (i) reducing the dietary intake of fat to ~25% of the total calories, (ii) eating at least 5 portions of fruit and vegetables a day, (iii) increasing the intake of fibre and reducing refined carbohydrates, and (iv) taking moderate amounts of alcohol. Outcome measures will include body weight and body composition, psychological health status (stress and depression), cardiorespiratory fitness and quality of life. In addition, biomarkers associated with disease recurrence, including stress hormones, estrogen status, inflammatory markers and indices of innate and adaptive immune function will be monitored. Discussion This research will provide valuable information on the effectiveness of a practical, easily implemented lifestyle intervention for evoking positive effects on body weight and psychological well-being, two important factors that can influence long-term prognosis in breast cancer survivors. However, the added value of the study is that it will also evaluate the effects of the lifestyle intervention on a range of biomarkers associated with disease recurrence and survival. Considered together, the results should improve our understanding of the potential role that lifestyle-modifiable factors could play in saving or prolonging lives

Effizienzsteigerung numerischer Verfahren der nichtlinearen Optimierung

This thesis focuses on the development of multiple different techniques to improve the efficiency of nonlinear optimization algorithms. The contribution of this work can be divided in three main parts. Having a closer look on an Sequential Quadratic Programming (SQP) algorithm (namely the solver WORHP) theoretical results about the inertia of the system matrix in the case of SQP with interior-point-method for the solution of the subproblems are given and an adaptive relaxation scheme to handle inconsistent constraints is developed. Using parametric sensitivity analysis multiple algorithms to improve the SQP method are presented. These focus mainly on the handling of nonlinear constraints, but a new strategy to improve the necessary regularization of the Hessian of the Lagrangian is shown as well. In addition to these algorithmic advancements a technical discussion about parallelism for nonlinear programming is given and used to develop a new multi-core capable interface

2-Eth­oxy-5-methylbis[1,2,4]triazolo[1,5-a:4′,3′-c]quinazoline

The title compound, C13H12N6O, is a functionalized ditriazoloquinazoline with substituted eth­oxy and methyl groups attached at the 2-position of each triazole spacer. The fused-ring system is essentially planar [r.m.s. deviation = 0.016 (2) Å]. In the crystal, a weak C—H⋯N hydrogen bond connects the mol­ecules into a chain along [101]

Arbeitsrecht in China: Soft-Law oder Steuerung? (Teil 2)

Das chinesische Arbeitsrecht ist bereits seinem Inhalt nach teilweise „soft-law“. Es beinhaltet die Abkehr vom Grundsatz der Festanstellung der Arbeitnehmer und schafft durch befristete Arbeitsverhältnisse und einen nur sehr begrenzten Kündigungsschutz aus der Sicht der Unternehmer hohe Flexibilität, aus der Sicht der Arbeitnehmer einen geringen Arbeitsplatzschutz. Dennoch enthält es in einer Reihe von Punkten (Überstundenvergütung, Beteiligung von Gewerkschaften, Arbeitsschutzbestimmungen etc.) auch eher strikte Regelungen im Interesse der Arbeitnehmer

Arbeitsrecht in China: Soft-Law oder Steuerung? (Teil 1)

Trotz SARS ist das wirtschaftliche Wachstum Chinas im Wesentlichen ungebrochen. Beinahe täglich wächst das wirtschaftliche und damit außenpolitische Gewicht der Volksrepublik. Andererseits hat das anhaltende Wachstum zu enormen Disparitäten in der Verteilung des wirtschaftlichen Reichtums geführt. Der extreme Preisanstieg hat die Freisetzung ländlicher Arbeitskräfte und deren Migration in Richtung Osten und Küste beschleunigt. Schätzungen sprechen von 150 Mio., z.T. sogar von bis zu 300 Mio. Wanderarbeitnehmern innerhalb Chinas. Die Transformation der sozialistischen Staatswirtschaft in ein marktwirtschaftlich orientiertes System vergrößert auch die Arbeitslosigkeit in den Städten: Nicht alle von Staatsbetrieben freigesetzten Arbeitnehmer können von neugegründeten Privatunternehmen übernommen werden

Zufriedenheit der Mütter und Therapeuten mit verschiedenen Behandlungsmodulen der Familientagesklinik Münster

Im Rahmen einer Studie wurde die Zufriedenheit der Mütter und Therapeuten mit verschiedenen Behandlungsmodulen der Familientagesklinik für Säuglinge, Klein- und Vorschulkinder der Kinder- und Jugendpsychiatrie Münster anhand eines Fragebogens untersucht. Die Stichprobe setzte sich aus 131 Kindern und ihren Müttern zusammen, die zwischen 2001 und 2008 behandelt wurden. Insgesamt betrug bei der Messung der Zufriedenheit der Mittelwert über alle Therapiemodule bei den Müttern 1,96, was der Note „gut“ entspricht. Mit einem Mittelwert über alle Therapiemodule von 2,30 wiesen auch die Therapeuten eine hohe Zufriedenheit auf. Post-hoc wurde der Zusammenhang zwischen der Behandlungszufriedenheit und standardisierten Erfolgsmaßen für das Kind und die Mutter untersucht. Eine statistisch signifikante Verbesserung der Psychopathologie des Kindes (CBCL Total Problem Score) und der Mutter (GSI des SCL-90-R) bestätigten den Behandlungserfolg der familientagesklinischen Behandlung.<br