India's product patent protection regime: Less or more of "pills for the poor"?

The year 2005 marks the end of transition period for many developing countries with competent pharmaceutical sectors that competed in supplying generic versions of patented drugs to LDCs before, thereby inducing price competition and enhancing access to medicines. In a post-2005 scenario, the critical issue is whether LDCs without adequate manufacturing capabilities can make use of compulsory licensing expeditiously to induce price competition and secure lower prices. This paper uses empirical evidence collected during a firm-level survey of the Indian pharmaceutical sector to generate evidence on emerging strategies of firms. It shows that the vigour of compulsory licensing as a price-leveraging instrument post-2005 is incumbent mainly on its economic feasibility. It shows that Indian firms view the market potential (in terms of market size and profits involved in such supply, especially if they have to make specific technological investments to produce the drug) of the mechanism much more severely than before, and may be less inclined to engage in such production if their commercial expectations are grossly unmet. The analysis assesses implications of emerging strategies of firms in the Indian pharmaceutical sector for access to medicines both domestically and internationally, and highlights the challenges involved.product patents, Indian pharmaceuticals, generics, access

Indian Pharma Within Global Reach?

The Indian pharmaceutical industry is presently going through a phase of transition and potential consolidation, owing to India's new TRIPS-compliant intellectual property regime and other rules aimed at enhancing the industry's credibility nationally and internationally. Appropriate policy interventions can play a large role in cushioning the transition (and gradual consolidation) of the industry post-2005. Using firm level data collected in 2004-2005, this paper seeks to make two major contributions in this regard. The research findings show that the Indian pharmaceutical sector is a heterogeneous mix of firms with vast differences in innovative capabilities. Based on these differences, the groups can be categorized into specific "innovation modes" (the innovator, the niche operator and the manufacturer), each mode being a step closer towards the innovative pharmaceutical firm. Second, the paper highlights how the emerging strategies of firms in all three groups, although different, underpin the importance of systemic coordination in the pharmaceutical sector. The analysis links both these findings to policies pursued in the pharmaceutical sector over the past four decades and highlights the role of differential innovation policy in ensuring optimal sectoral performance.Pharmaceutical industry, Innovation policy, TRIPS, Intellectual Propery, IPR, Property rights, India

On the Cultural Power of the “Marianas Web” Meme

Explores the Marianas Web meme as a cultural myth. Special appearance by Rudy Giuliani

Rough Road to Market: Institutional Barriers to Innovations in Africa

Translating R&D and inventive efforts into a market product is characterized by significant financial skills, and the ability to overcome technical and instititonal barriers. Research into and translation of new technologies such as biotechnology products to the market requires even greater resources. This paper aims to understand the key factors that foster or hinder the complex process of translating R&D efforts into innovative products. Different pathways exist in developed countries such as firm-level efforts, the use of IPs, the spin-off of new firms that develop new products, or a mixture of these. Developing countries differ substantially in the kinds of instruments they use because of their considerably weaker institutional environment and for this reason our framework takes a systemic and institutional perspective. The paper comtributes to this issue by examining systemic institutional barriers to commercializing biotechnology in a develping context within a systems of innovation framework.research and development, biotechnology, commercialization, innovation, Africa, learning, institution building

Multidimensional Coherent Spectroscopy of a Semiconductor Microcavity

Rephasing and non-rephasing two-dimensional coherent spectra map the anti-crossing associated with normal-mode splitting in a semiconductor microcavity. For a 12-meV detuning range near zero detuning, it is observed that there are two diagonal features related to the intra-action of exciton-polariton branches and two off-diagonal features related to coherent interaction between the polaritons. At negative detuning, the lineshape properties of the diagonal intra-action features are distinguishable and can be associated with cavity-like and exciton-like modes. A biexcitonic companion feature is observed, shifted from the exciton feature by the biexciton binding energy. Closer to zero detuning, all features are enhanced and the diagonal intra-action features become nearly equal in amplitude and linewidth. At positive detuning the exciton- and cavity-like characteristics return to the diagonal intra-action features. Off-diagonal interaction features exhibit asymmetry in their amplitudes throughout the detuning range. The amplitudes are strongly modulated (and invert) at small positive detuning, as the lower polariton branch crosses the bound biexciton energy determined from negative detuning spectra.Comment: 13 pages, 4 figure

Archives for the Dark Web: A Field Guide for Study

This chapter provides a field guide for other digital humanists who want to study the Dark Web. In order to focus the chapter, I emphasize my belief that, in order to study the cultures of Dark Web sites and users, the digital humanist must engage with these systems' technical infrastructures. I will provide specific reasons why I believe that understanding the technical details of Freenet, Tor, and I2P will benefit any researchers who study these systems, even if they focus on end users, aesthetics, or Dark Web cultures. To this end, I offer a catalog of archives and resources researchers could draw on and a discussion of why researchers should build their own archives. I conclude with some remarks about ethics of Dark Web research

On deadlock detection in distributed computing systems

With the advent of distributed computing systems, the problem of deadlock, which has been essentially solved for centralized computing systems, has reappeared. Existing centralized deadlock detection techniques are either too expensive or they do not work correctly in distributed computing systems. Although several algorithms have been developed specifically for distributed systems, the majority of them have also been shown to be inefficient or incorrect. A new algorithm is proposed which is more efficient than any existing distributed deadlock detection algorithm. (Author)supported in part by the Foundation Research Program of the Naval Postgraduate School with funds provided the by Chief of Naval Researchhttp://archive.org/details/ondeadlockdetect00badaApproved for public release; distribution is unlimited

A Pan-European representative ground motion model

This poster is ESC2016-527 in the 35th General Assembly of the European Seismological Commission (Trieste, 4-10 September 2016)Ground motion prediction equations (GMPE) are recognised as a key component of any seismic risk analysis. The consideration of both aleatory and epistemic sources of variability in the ground motion models may have significant influence on the overestimation or underestimation of the final losses. With the increased availability of new developed GMPEs over the past few years, it has been observed that the epistemic uncertainty due the choice between potential GMPEs is not decreasing, even though related knowledge is improving.The proposed model enables a complex problem to be represented by a minimum number of branches for single-site hazard analysis and mapping. A preliminary application is carried out for a critical infrastructure risk analysis in the framework of the EU-funded INFRARISK project (European Commission’s FP7 programme, Grant Agreement No. 603960)Peer Reviewe

Product Service System Innovation in the Smart City

Product service systems (PSS) may usefully form part of the mix of innovations necessary to move society toward more sustainable futures. However, despite such potential, PSS implementation is highly uneven and limited. Drawing on an alternate socio-technical perspective of innovation, this paper provides fresh insights, on among other things the role of context in PSS innovation, to address this issue. Case study research is presented focusing on a use orientated PSS in an urban environment: the Copenhagen city bike scheme. The paper shows that PSS innovation is a situated complex process, shaped by actors and knowledge from other locales. It argues that further research is needed to investigate how actors interests shape PSS innovation. It recommends that institutional spaces should be provided in governance landscapes associated with urban environments to enable legitimate PSS concepts to co-evolve in light of locally articulated sustainability principles and priorities

Characterization of 1D photonic crystal nanobeam cavities using curved microfiber

We investigate high-Q, small mode volume photonic crystal nanobeam cavities using a curved, tapered optical microfiber loop. The strength of the coupling between the cavity and the microfiber loop is shown to depend on the contact position on the nanobeam, angle between the nanobeam and the microfiber, and polarization of the light in the fiber. The results are compared to a resonant scattering measurement