Experimental determination of the transient transport and of fluctuations relevant to transport in ASDEX

Particle transport was studied in ASDEZ with modulated puffing of the discharge gas and of impurities. The energy transport is investigated by numerical simulation of the heat pulse after the swatooth crash. Small scale density fluctuations are investigated in the confinement region with far infrared scattering and reflectometry and in the edge plasma with langmuir probes and Ha diagnostic. In addition to a diffuse component of the particle transport, a strong inward drift is observed in all discharges. In ohmic discharges the transport coefficients decrease and saturate like 1/TE with increasing density. They are smaller in deuterium that in hydrogen. In the improved ohmic confinement (IOC)regime mainly D in the outer region is reduced. D increases proportionally to the heating power in L-mode discharges. The improvement of particle confinement in the H-mode is explained by a increase of the inward drift at the edge rather than a decrease of D. The impurity diffusion coefficient is independent of the impurity mass and charge. In ohmic discharges, it varies with ne like the bulk diffusion coefficient, is independent of B or increases weakly with B and increases with Ip. In L-mode discharges, Dimp increases linearly with the heating power. The electron thermal condustivity determined by heat pulse propagation exceeds the stationary value by a factor of 3-4, assuming merely diffusive heat transport. Convection does not significantly reduce this factor. however, non-diagonal terms

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.We thank S. Lecher, S. Li and J. Zallet for technical support. Calculations were performed at the sciCORE scientific computing core facility at the University of Basel. This work was supported by the Swiss National Science Foundation (grants 310030_166687 (S.G.) and 320030_153442 (M.E.) and Swiss HIV Cohort Study grant 740 to L.F.), the European Research Council (309540-EVODRTB to S.G.), TB-PAN-NET (FP7-223681 to S.N.), PathoNgenTrace projects (FP7-278864-2 to S.N.), SystemsX.ch (S.G.), the German Center for Infection Research (DZIF; S.N.), the Novartis Foundation (S.G.), the Natural Science Foundation of China (91631301 to Q.G.), and the National Institute of Allergy and Infectious Diseases (5U01-AI069924-05) of the US National Institutes of Health (M.E.)

Coarse‐Grained Refractory Composite Castables Based on Alumina and Niobium

Niobium-alumina composite aggregates with 60 vol% metal content and with particle sizes up to 3150 μm are produced using castable technology followed by sintering, and a crushing and sieving process. X-Ray diffraction (XRD) analysis reveals phase separation during crushing as the niobium:corundum volume ratios is between 37:57 and 64:31 among the 4 produced aggregate classes 0–45, 45–500, 500–1000, and 1000–3150 μm. The synthesized aggregates are used to produce coarse-grained refractory composites in a second casting and sintering step. The fine- and coarse-grained material shows porosities between 32% and 36% with a determined cold modulus of rupture of 20 and 12 MPa, and E-moduli of 37 and 46 GPa, respectively. The synthesized fine-grained composites reached true strain values between 0.08 at 1100 °C and 0.18 at 1500 °C and the coarse-grained ones values between 0.02 and 0.09. The electrical conductivity for the fine-grained and the coarse-grained material is 448±66 and 111±25  S cm$^{−1}$, respectively

Turbulent particle transport in magnetized fusion plasma

The understanding of the mechanisms responsible for particle transport is of the utmost importance for magnetized fusion plasmas. A peaked density profile is attractive to improve the fusion rate, which is proportional to the square of the density, and to self-generate a large fraction of non-inductive current required for continuous operation. Experiments in various tokamak devices (AUG, DIII-D, JET, TCV, TEXT, TFTR) have indicated the existence of an anomalous inward particle pinch. Recently, such an anomalous pinch has been unambiguously identified in Tore Supra very long discharges, in absence of toroidal electric field and of central particle source, for more than 4 minutes [1]. This anomalous particle pinch is predicted by a quasilinear theory of particle transport [2], and confirmed by non-linear turbulence simulations [3] and general considerations based on the conservation of motion invariants [4]. Experimentally, the particle pinch is found to be sensitive to the magnetic field gradient in many cases [5, 6, 7, 8], to the temperature profile [5, 9] and also to the collisionality that changes the nature of the microturbulence [10, 11, 12]. The consistency of some of the observed dependences with the theoretical predictions gives us a clearer understanding of the particle pinch in tokamaks, allowing us to predict more accurately the density profile in ITER.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004, Nice (France

3D Reconstruction for Partial Data Electrical Impedance Tomography Using a Sparsity Prior

In electrical impedance tomography the electrical conductivity inside a physical body is computed from electro-static boundary measurements. The focus of this paper is to extend recent result for the 2D problem to 3D. Prior information about the sparsity and spatial distribution of the conductivity is used to improve reconstructions for the partial data problem with Cauchy data measured only on a subset of the boundary. A sparsity prior is enforced using the $\ell_1$ norm in the penalty term of a Tikhonov functional, and spatial prior information is incorporated by applying a spatially distributed regularization parameter. The optimization problem is solved numerically using a generalized conditional gradient method with soft thresholding. Numerical examples show the effectiveness of the suggested method even for the partial data problem with measurements affected by noise.Comment: 10 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:1405.655