Strengthening Ontario\u27s System of Housing for People with Serious Mental Illness

This article describes recent work to support recommendations for improving Ontario’s system of housing for people with serious mental illness. This multifaceted project engaged stakeholders in discussions concerning strategies for improving the system based on (a) values that underlie housing programs, (b) evidence of effective housing practices, (c) the current status of the system, and (d) international practices for monitoring community mental health systems. Stakeholders reviewed summaries of the work and discussed implications for improving the provincial system of housing and supports. Recommendations are made for improving the system, focusing on both regional and provincial level actions

Wind loads on ground-based telescopes

One of the factors that can influence the performance of large optical telescopes is the vibration of the telescope structure due to unsteady wind inside the telescope enclosure. Estimating the resulting degradation in image quality has been difficult because of the relatively poor understanding of the flow characteristics. Significant progress has recently been made, informed by measurements in existing observatories, wind-tunnel tests, and computational fluid dynamic analyses. We combine the information from these sources to summarize the relevant wind characteristics and enable a model of the dynamic wind loads on a telescope structure within an enclosure. The amplitude, temporal spectrum, and spatial distribution of wind disturbances are defined as a function of relevant design parameters, providing a significant improvement in our understanding of an important design issue

Mission Planner Algorithm for Urban Air Mobility Initial Performance Characterization

In this paper, an initial characterization was performed of the Mission Planner algorithm developed by NASA for Urban Air Mobility (UAM) operations research. The algorithm plans conflict-free trajectories for flights to support a given set of UAM passenger trips. The UAM trips are planned in an on-demand, first-come, first-served manner, such that any given trip is subject to the constraints imposed by previously planned trips. For this analysis, the mission planning algorithm considered only the trajectory constraints from previously-planned trips in one test condition and added vertiport constraints for the second test condition. The conflict and constraint resolution strategies used by the Mission Planner were characterized by their percentage contribution to planning iterations, their percentage effectiveness in those iterations, and their contributions to the departure delay applied to each UAM trips flight. With the exception of the climb and descent vertical speed strategies, most strategies showed reasonable or good performance in all test scenarios. In the test condition with vertipad constraints enabled, both the total number of iterations executed, and the number of flights that required planning iterations, was reduced for all scenarios. This was the result of the natural conditioning of the traffic achieved with scheduling and the additional information available to the Mission Planner from the vertiport scheduler. The next steps for this work will include improvements to the mission planning strategies and analyses with additional constraints and under other demand scenarios

Biennial wormwood (Artemisia biennis) competition with soybean (Glycine max)

Biennial wormwood has become a serious weed of several crops in the northern Great Plains of the United States and Prairie Provinces of Canada. Greenhouse replacement series experiments were conducted to investigate the effects of watering regime (stressed and non-stressed) and nitrogen rate (50, 100, 150, and 200 mg kg-1 of soil) on competition between soybean and biennial wormwood. Soybean height was reduced after 9 weeks of competition with biennial wormwood compared with soybean grown in monoculture, whereas biennial wormwood plants were taller when grown with soybean than in monoculture. The change in plant height indicated that biennial wormwood height was increased due to interspecific competition, whereas soybean height was reduced. When moisture was limited, the relative yield of biennial wormwood was greater than that of soybean, indicating that biennial wormwood was more aggressive than soybean. Soybean growth was unaffected by an increase in nitrogen rate, whereas biennial wormwood fresh weight was 30% greater when the nitrogen rate was increased from 50 to 200 mg kg-1. Biennial wormwood aggressivity tended to increase as the nitrogen rate was increased from 50 to 200 mg kg-1. Overall results suggest that the negative impact of biennial wormwood competition with soybeans under field conditions may increase when soil moisture is limited and nitrogen fertility is increased.L'armoise bisannuelle est devenue une importante mauvaise herbe pour plusieurs cultures dans le nord des Grandes Plaines des États-Unis et dans les provinces des Prairies au Canada. Des expériences avec des séries de remplacement ont été menées en serre afin d'étudier les effets du régime d'alimentation en eau (stressant et non stressant) et de la quantité d'azote (50, 100, 150 et 200 mg kg-1 de sol) sur la compétition entre le soja et l'armoise bisannuelle. Après 9 semaines de compétition avec l'armoise bisannuelle, la taille du soja était inférieure à celle du soja en monoculture alors que l'armoise bisannuelle était plus grande en présence de soja qu'en monoculture. Les différences dans la taille des plantes montrent que la compétition interspécifique a fait augmenter celle de l'armoise bisannuelle et diminuer celle du soja. Lorsque l'eau était un facteur limitatif, le rendement relatif de l'armoise bisannuelle était plus élevé que celui du soja, ce qui montre que l'armoise bisannuelle était plus agressive que le soja. L'augmentation de la quantité d'azote n'a pas affecté la croissance du soja. Cependant, le poids de matière fraîche de l'armoise bisannuelle était 30 % plus élevé lorsque la quantité d'azote est passée de 50 à 200 mg kg-1. L'agressivité de l'armoise bisannuelle a eu tendance à augmenter lorsque la quantité d'azote est passée de 50 à 200 mg kg-1. Globalement, les résultats montrent que les impacts négatifs de la compétition entre l'armoise bisannuelle et le soja, dans des conditions naturelles, peuvent s'accroître lorsque l'eau manque et que la quantité d'azote disponible augmente

Genome-wide association study identifies common and low-frequency variants at the AMHgene locus that strongly predict serum AMH levels in males

Anti-Müllerian hormone (AMH) is an essential messenger of sexual differentiation in the foetus and is an emerging biomarker of postnatal reproductive function in females. Due to a paucity of adequately sized studies, the genetic determinants of circulating AMH levels are poorly characterized. In samples from 2815 adolescents aged 15 from the ALSPAC study, we performed the first genome-wide association study of serum AMH levels across a set of ∼9 M ‘1000 Genomes Reference Panel’ imputed genetic variants. Genetic variants at the AMH protein-coding gene showed considerable allelic heterogeneity, with both common variants [rs4807216 (PMale = 2 × 10−49, Beta: ∼0.9 SDs per allele), rs8112524 (PMale = 3 × 10−8, Beta: ∼0.25)] and low-frequency variants [rs2385821 (PMale = 6 × 10−31, Beta: ∼1.2, frequency 3.6%)] independently associated with apparently large effect sizes in males, but not females. For all three SNPs, we highlight mechanistic links to AMH gene function and demonstrate highly significant sex interactions (PHet 0.0003–6.3 × 10−12), culminating in contrasting estimates of trait variance explained (24.5% in males versus 0.8% in females). Using these SNPs as a genetic proxy for AMH levels, we found no evidence in additional datasets to support a biological role for AMH in complex traits and diseases in men

General anesthesia does not have persistent effects on attention in rodents

Background: Studies in animals have shown that general anesthesia can cause persistent spatial memory impairment, but the influence of anesthetics on other cognitive functions is unclear. This study tested whether exposure to general anesthesia without surgery caused a persistent deficit in attention in rodents.Methods: To evaluate whether anesthesia has persistent effects on attention, rats were randomized to three groups. Group A was exposed for 2 h to isoflurane anesthesia, and tested the following seven days for attentional deficits. Group B was used as a control and received room air before attentional testing. Since there is some evidence that a subanesthetic dose of ketamine can improve cognition and reduce disorders of attention after surgery, rats in group C were exposed to isoflurane anesthesia in combination with a ketamine injection before cognitive assessment. Attention was measured in rats using the 5-Choice Serial Reaction Time Task, for which animals were trained to respond with a nose poke on a touchscreen to a brief, unpredictable visual stimulus in one of five possible grid locations to receive a food reward. Attention was analyzed as % accuracy, % omission, and premature responses.Results: Evaluating acute attention by comparing baseline values with data from the day after intervention did not reveal any differences in attentional measurements. No significant differences were seen in % accuracy, % omission, and premature responses for the three groups tested for 7 consecutive days.Conclusion: These data in healthy rodents suggest that general anesthesia without surgery has no persistent effect on attention and the addition of ketamine does not alter the outcome

Predicting wave-induced ripple equilibrium geometry

Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 118 (2013): 3202–3220, doi:10.1002/jgrc.20241.A comprehensive database of existing (since 1954) field and laboratory measurements of ripple geometry is compiled and combined with newly collected field data to examine the performance of ripple equilibrium predictors. Reanalysis of this enlarged ripple geometry data set reveals that ripples formed from monochromatic waves scale differently than ripples formed from random waves for many existing ripple predictors. Our analysis indicates that ripple wavelengths from the two data sets collapse into a single scaling when the semiorbital excursion and sediment grain diameter are used as normalizing factors. Ripple steepness remains relatively constant for both regular and irregular wave conditions, and it only slightly increases for shorter ripple wavelengths. These findings allowed for the development of a new equilibrium ripple predictor suitable for application in a wide range of wave and sediment conditions.Financial support for this work was provided by the National Science Foundation (NSF awards OCE-0451989 and OCE-0535893) and by the South Carolina Coastal Erosion Project, a cooperative study supported by the U.S. Geological Survey and the South Carolina Sea Grant Consortium (Sea Grant Project R/CP-11).2013-12-2

Maternal thyroid function and child educational attainment: prospective cohort study

Objective: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. Design: Prospective cohort study. Setting: Avon Longitudinal Study of Parents and Children cohort in the UK. Participants: 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12). Exposures: Free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function. Main outcome measures: Five age-specific national curriculum assessments in 3580 children at entry stage assessment at 54 months, increasing up to 4461 children at their final school assessment at age 15. Results: No strong evidence of clinically meaningful associations of first trimester free thyroxine and thyroid stimulating hormone levels with entry stage assessment score or Standard Assessment Test scores at any of the key stages was found. Associations of maternal free thyroxine or thyroid stimulating hormone with the total number of General Certificates of Secondary Education (GCSEs) passed (range 0-16) were all close to the null: free thyroxine, rate ratio per pmol/L 1.00 (95% confidence interval 1.00 to 1.01); and thyroid stimulating hormone, rate ratio 0.98 (0.94 to 1.02). No important relationship was observed when more detailed capped scores of GCSEs allowing for both the number and grade of pass or when language, mathematics, and science performance were examined individually or when all educational assessments undertaken by an individual from school entry to leaving were considered. 200 (4.3%) mothers were newly identified as having hypothyroidism or subclinical hypothyroidism and 97 (2.1%) subclinical hyperthyroidism or hyperthyroidism. Children of mothers with thyroid dysfunction attained an equivalent number of GCSEs and equivalent grades as children of mothers with euthyroidism. Conclusions: Maternal thyroid dysfunction in early pregnancy does not have a clinically important association with impaired child performance at school or educational achievement

Is strong CP invariance due to a massless up quark?

A standing mystery in the Standard Model is the unnatural smallness of the strong CP violating phase. A massless up quark has long been proposed as one potential solution. A lattice calculation of the constants of the chiral Lagrangian essential for the determination of the up quark mass, 2 alpha_8 - alpha_5, is presented. We find 2 alpha_8 - alpha_5 = 0.29 +/- 0.18, which corresponds to m_u / m_d = 0.410 +/- 0.036. This is the first such calculation using a physical number of dynamical light quarks, N_f = 3.Comment: 4 pages, 5 figures, submitted to Phys. Rev. Lett., corrected small normalization error in f_pi (conclusions were unaffected), improved lattice spacing analysis, improved finite volume analysi