Genome sequences of 15 Gardnerella vaginalis strains isolated from the vaginas of women with and without bacterial vaginosis

Gardnerella vaginalis is a predominant species in bacterial vaginosis, a dysbiosis of the vagina that is associated with adverse health outcomes, including preterm birth. Here, we present the draft genome sequences of 15 Gardnerella vaginalis strains (now available through BEI Resources) isolated from women with and without bacterial vaginosis

Is there Evidence for Flat Cores in the Halos of Dwarf Galaxies?: The Case of NGC 3109 and NGC 6822

Two well studied dwarf galaxies -- NGC 3109 and NGC 6822 -- present some of the strongest observational support for a flat core at the center of galactic dark matter (DM) halos. We use detailed cosmologically motivated numerical models to investigate the systematics and the accuracy of recovering parameters of the galaxies. Some of our models match the observed structure of the two galaxies remarkably well. Our analysis shows that the rotation curves of these two galaxies are instead quite compatible with their DM halos having steep cuspy density profiles. The rotation curves in our models are measured using standard observational techniques. The models reproduce the rotation curves of both galaxies, the disk surface brightness profiles as well as the profile of isophotal ellipticity and position angle. The models are centrally dominated by baryons; however, the dark matter component is globally dominant. The simulated disk mass is marginally consistent with a stellar mass-to-light ratio in agreement with the observed colors. We show that non-circular motions combined with gas pressure support and projection effects results in a large underestimation of the circular velocity in the central $\sim 1$ kpc region, creating the illusion of a constant density core. Although the systematic effects mentioned above are stronger in barred systems, they are also present in axisymetric disks. Our results strongly suggest that there is no contradiction between the observed rotation curves in dwarf galaxies and the cuspy central dark matter density profiles predicted by Cold Dark Matter models.Comment: Accepted for publication in the ApJ. New discussion, figures and one appendix. High resolution version at:http://www.astro.washington.edu/octavio/N3109_paper.ps.g

Private Management and Operation of The Space Shuttle: Some Legal Problems Related To Market Entry

Most of the private enterprise constituency interested in participating in the commercial exploitation of near and deep space will be subject to a multitude of new laws and entire legal regimes, ranging in scope from public and private international law to domestic legislation, implementing regulations and, even the old and new anti-trust laws. The majority of the interested business community has no idea that an amalgam of specific legal principles and regimes already exists of sufficient distinction to be called space law

Mathematical analysis of a model for the growth of the bovine corpus luteum.

The corpus luteum (CL) is an ovarian tissue that grows in the wound space created by follicular rupture. It produces the progesterone needed in the uterus to maintain pregnancy. Rapid growth of the CL and progesterone transport to the uterus require angiogenesis, the creation of new blood vessels from pre-existing ones, a process which is regulated by proteins that include fibroblast growth factor 2 (FGF2). In this paper we develop a system of time-dependent ordinary differential equations to model CL growth. The dependent variables represent FGF2, endothelial cells (ECs), luteal cells, and stromal cells (like pericytes), by assuming that the CL volume is a continuum of the three cell types. We assume that if the CL volume exceeds that of the ovulated follicle, then growth is inhibited. This threshold volume partitions the system dynamics into two regimes, so that the model may be classified as a Filippov (piecewise smooth) system. We show that normal CL growth requires an appropriate balance between the growth rates of luteal and stromal cells. We investigate how angiogenesis influences CL growth by considering how the system dynamics depend on the dimensionless EC proliferation rate, ρ₅. We find that weak (low ρ₅) or strong (high ρ₅) angiogenesis leads to 'pathological' CL growth, since the loss of CL constituents compromises progesterone production or delivery. However, for intermediate values of ρ₅, normal CL growth is predicted. The implications of these results for cow fertility are also discussed. For example, inadequate angiogenesis has been linked to infertility in dairy cows