Swain Committee Report

Letter addressed to the Secretary of the Navy, the Honorable Josephus H. Daniels, from the Committee appointed by the President of the Society for the Promotion of Engineering Education, to visit the U.S. Naval Academy in Annapolis, MD. The purpose was to evaluate the work of the Post Graduate School. The committee recommended enlarging the enrollment of the Post Graduate School and providing for appropriate funding for buildings, equipment and curricula

Two independent S-phase checkpoints regulate appressorium-mediated plant infection by the rice blast fungus Magnaporthe oryzae

To cause rice blast disease, the fungal pathogen Magnaporthe oryzae develops a specialized infection structure called an appressorium. This dome-shaped, melanin-pigmented cell generates enormous turgor and applies physical force to rupture the rice leaf cuticle using a rigid penetration peg. Appressorium-mediated infection requires septin-dependent reorientation of the F-actin cytoskeleton at the base of the infection cell, which organizes polarity determinants necessary for plant cell invasion. Here, we show that plant infection by M. oryzae requires two independent S-phase cell-cycle checkpoints. Initial formation of appressoria on the rice leaf surface requires an S-phase checkpoint that acts through the DNA damage response (DDR) pathway, involving the Cds1 kinase. By contrast, appressorium repolarization involves a novel, DDR-independent S-phase checkpoint, triggered by appressorium turgor generation and melanization. This second checkpoint specifically regulates septin- dependent, NADPH oxidase-regulated F-actin dynamics to organize the appressorium pore and facilitate entry of the fungus into host tissue

Upper Extremity Composite Tissue Allotransplantation Imaging

Objective: Upper extremity (UE) transplantation is the most commonly performed composite tissue allotransplantation worldwide. However, there is a lack of imaging standards for pre- and posttransplant evaluation. This study highlights the protocols and findings of UE allotransplantation toward standardization and implementation for clinical trials. Methods: Multimodality imaging protocols for a unilateral hand transplant candidate and a bilateral mid-forearm level UE transplant recipient include radiography, computed tomography (CT), magnetic resonance (MR) imaging, catheter angiography, and vascular ultrasonography. Pre- and posttransplant findings, including dynamic CT and MR performed for assessment of motor activity of transplanted hands, are assessed, and image quality of vessels and bones on CT and MR evaluated. Results: Preoperative imaging demonstrates extensive skeletal deformity and variation in vascular anatomy and vessel patency. Posttransplant images confirm bony union in anatomical alignment and patency of vascular anastomoses. Mild differences in rate of vascular enhancement and extent of vascular networks are noted between the 2 transplanted limbs. Dynamic CT and MR demonstrate a 15° to 30° range of motion at metacarpophalangeal joints and 90° to 110° at proximal interphalangeal joints of both transplanted hands at 8 months posttransplant. Image quality was slightly better for CT than for MR in the first subject, while MR was slightly better in the second subject. Conclusion: Advanced vascular and musculoskeletal imaging play an important role in surgical planning and can provide novel posttransplantation data to monitor the success of the procedure. Implementation of more standardized protocols should enable a more comprehensive assessment to evaluate the efficacy in clinical trials

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far

The principles of communicative language use

The paper aims to overview some typical principles of communicative language use in a cognitive pragmatic approach applying a reductionist method in order to demonstrate that the well-known principles can be reduced to a very general rationality (economy) principle. After briefly reviewing the principles the paper re-evaluates them and provides a new classification of them relying on the definition of ostensive-inferential communication. The principles which can be divided into rationality and interpersonality principles are really principles of effective information transmission on objects and selves. They refer to two kinds of language use: informative and communicative ones. The only principles valid for only communicative language use are the communicative principle of relevance and the principle of communicative intention suggested in the present article. Finally, the paper reduces all rationality and interpersonality principles to a very general rationality principle, i.e., the cognitive principle of relevance

Structure of the master regulator Rns reveals an inhibitor of enterotoxigenic Escherichia coli virulence regulons

Enteric infections caused by the gram-negative bacteria enterotoxigenic Escherichia coli (ETEC), Vibrio cholerae, Shigella flexneri, and Salmonella enterica are among the most common and affect billions of people each year. These bacteria control expression of virulence factors using a network of transcriptional regulators, some of which are modulated by small molecules as has been shown for ToxT, an AraC family member from V. cholerae. In ETEC the expression of many types of adhesive pili is dependent upon the AraC family member Rns. We present here the 3 Å crystal structure of Rns and show it closely resembles ToxT. Rns crystallized as a dimer via an interface similar to that observed in other dimeric AraC’s. Furthermore, the structure of Rns revealed the presence of a ligand, decanoic acid, that inhibits its activity in a manner similar to the fatty acid mediated inhibition observed for ToxT and the S. enterica homologue HilD. Together, these results support our hypothesis that fatty acids regulate virulence controlling AraC family members in a common manner across a number of enteric pathogens. Furthermore, for the first time this work identifies a small molecule capable of inhibiting the ETEC Rns regulon, providing a basis for development of therapeutics against this deadly human pathogen

Flamingo Vol. II N 3

Punch Bowl. A Previous Engagement . Prose. 1. Burr. Untitled. Prose. 1. Ubersax, Delmar. Untitled. Picture. 4. Mather, William G. Shelf 378C . Prose. 5. Bennett, G.W. Esotery . Poem. 6. W.A.V. Untitled. Poem. 6. Anonymous. Approved Subjects of Conversation . Poem. 7. Anonymous. Pipe Up . Prose. 7. Anonymous. Denison\u27s Hall of Fame: Francis W. Shepardson . Prose. 8 M.E. Percy . Poem. 9.; A.F.T. Triolet . Poem. 9. Anonymous. Untitled. Picture. 9. W.G.K. The Message of a Leader-Autobiographical . Prose. 9. Keeler, Clyde. Untitled. Picture. 10. Anonymous. Untitled. Prose. 10. Potter, W.M. Prose Fiction . Poem. 11. Keeler, Clyde. Untitled. Picture. 11. Anonymous. The Night After Christmas . Prose. 11. Anonymous. Untitled. Prose. 11. Anonymous. Popular Illusions Shattered . Prose. 11. Anonymous. Throw Him Into The Green River! . Poem. 12. Anonymous. Candid . Prose. 12. Holt, Kilburn. Favorite Poems (Revised Edition) . Poem. 12. Anonymous. Untitled. Prose. 14. Anonymous. Proof that Winter is Here . Cartoon. 16. F. The Inefficiency Medal . Prose. 18. Anonymous. Untitled. Picture. 18. Anonymous. Untitled. Prose. 18. Ed. A Pathetic Fallacy . Poem. 19. Ubersax, Delmar. Untitled. Picture. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Picture. 19. Oh Min. The Baliff and The Bunk . Prose. 20. Anonymous. Reservoir . Prose. 20. Anonymous. Untitled. Prose. 20. Ed. and Delmar Ubersax. A Lass and a Lack . Picture. 20. Anonymous. Thrice Told Tales . Prose. 21. Anonymous. Untitled. Prose. 21. Anonymous. Untitled. Prose. 22. Keeler, Clyde. Untitled. Picture. 22. R. The Lover Sings . Poem. 23. Anonymous. Untitled. Prose. 23. Anonymous. Untitled. Picture. 23. Octopus. Untitled. Prose. 23. Anonymous. Untitled. Picture. 24. Anonymous. Untitled. Prose. 24. Keeler, Clyde. Untitled. Picture. 25. Anonymous. Untitled. Prose. 25. Punch Bowl. Untitled. Prose. 26. Orange Peel. Untitled. Prose. 26. Lampoon. Untitled. Prose. 26. Octopus. Untitled. Prose. 26. Sun Dodger. Untitled. Prose. 27. Phoenix. Untitled. Prose. 27. Dirge. Untitled. Prose. 27. Lampoon. Untitled. Prose. 27. Siren. Untitled. Prose. 27. Jester. Untitled. prose. 29. Frivol. Untitled. Prose. 29. Voo-Doo. Untitled. Prose. 29. Lampoon. Untitled. Prose. 29. Royal Gaboon. Untitled. Prose. 30. Octopus. Untitled. Prose. 30. Anonymous. Page Mr. Volstead . Prose. 30. Chaparral. Missing Cylinder . Prose. 30. Frivol. Untitled. Prose. 31. Widow. Bubbling over . Prose. 31. Juggler. The Order of The Bawth . Prose. 31. Tiger. Untitled. Prose. 31

Compilation of analyses of risks and measures, deliverable 8.2 of the H2020 project SafetyCube

This deliverable provides information on how the information on road safety risks and measures that has been collected within SafetyCube, is processed, stored and made available to users through the SafetyCube Decision Support System (DSS) [...continues]