Subsonic aerodynamic characteristics of a proposed advanced manned launch system orbiter configuration

The Advanced Manned Launch System is a proposed near-term technology, two-stage, fully reusable launch system that consists of an unmanned glide-back booster and a manned orbiter. An orbiter model that featured a large fuselage and an aft delta wing with tip fins was tested in the Langley 7- by 10-Foot High-Speed Tunnel. A crew cabin, large payload fairing, and crew access tunnel were mounted on the upper body. The results of the investigation indicated that the configuration was longitudinally stable to an angle of attack of about 6 deg about a center-of-gravity position of 0.7 body length. The model had an untrimmed lift-drag ratio of 6.6, but could not be trimmed at positive lift. The orbiter model was also directionally unstable. The payload fairing was responsible for about half the instability. The tip-fin controllers, which are designed as active controls to produce artificial directional stability, were effective in producing yawing moment, but sizable adverse rolling moment occurred at angles of attack above 6 deg. Differential deflection of the elevon surfaces was effective in producing rolling moment with only small values of adverse yawing moment

A recall-by-genotype study of CHRNA5-A3-B4 genotype, cotinine and smoking topography:study protocol

BACKGROUND: Genome-wide association studies have revealed an association between several loci in the nicotinic acetylcholine receptor gene cluster CHRNA5-A3-B4 and daily cigarette consumption. Recent studies have sought to refine this phenotype, and have shown that a locus within this cluster, marked primarily by rs1051730 and rs16969968, is also associated with levels of cotinine, the primary metabolite of nicotine. This association remains after adjustment for self-reported smoking, which suggests that even amongst people who smoke the same number of cigarettes there is still genetically-influenced variation in nicotine consumption. This is likely to be due to differences in smoking topography, that is, how a cigarette is smoked (e.g., volume of smoke inhaled per puff, number of puffs taken per cigarette). The aim of this study is to determine potential mediation of the relationship between the rs1051730 locus and cotinine levels by smoking topography. METHODS/DESIGN: Adopting a recall-by-genotype design, we will recruit 200 adults from the Avon Longitudinal Study of Parents and Children on the basis of minor or major homozygote status at rs1051730 (100 in each genotype group). All participants will be current, daily smokers. Our primary study outcome measures will be measures of smoking topography: total volume of smoke (ml) inhaled per cigarette, total volume of smoke (ml) inhaled over of the course of one day, and salivary cotinine level (ng/ml). DISCUSSION: This study will extend our understanding of the biological basis of inter-individual variability in heaviness of smoking, and therefore in exposure to smoking-related toxins. The novel recall-by-genotype approach we will use is efficient, maximising statistical power, and enables the collection of extremely precise phenotypic data that are impractical to collect in a larger sample. The methods described within this protocol also hold the potential for wider application in the field of molecular genetics

G = E:What GWAS Can Tell Us about the Environment

As our understanding of genetics has improved, genome-wide association studies (GWAS) have identified numerous variants associated with lifestyle behaviours and health outcomes. However, what is sometimes overlooked is the possibility that genetic variants identified in GWAS of disease might reflect the effect of modifiable risk factors as well as direct genetic effects. We discuss this possibility with illustrative examples from tobacco and alcohol research, in which genetic variants that predict behavioural phenotypes have been seen in GWAS of diseases known to be causally related to these behaviours. This consideration has implications for the interpretation of GWAS findings

Distance Measures for Reduced Ordering Based Vector Filters

Reduced ordering based vector filters have proved successful in removing long-tailed noise from color images while preserving edges and fine image details. These filters commonly utilize variants of the Minkowski distance to order the color vectors with the aim of distinguishing between noisy and noise-free vectors. In this paper, we review various alternative distance measures and evaluate their performance on a large and diverse set of images using several effectiveness and efficiency criteria. The results demonstrate that there are in fact strong alternatives to the popular Minkowski metrics

Effect of Succimer on Growth of Preschool Children with Moderate Blood Lead Levels.

Growth deficits associated with lead exposure might be ameliorated by chelation. We examined the effect of succimer on growth in 780 children 12-33 months old who had blood lead levels of 20-44 microg/dL and were randomized to receive up to three 26-day courses of succimer or placebo in a multicenter, double-blind trial. The difference in changes in weight and height between succimer and placebo groups at 1-34 months was calculated by fitting cubic splines. The difference in height change in children on succimer compared with placebo was -0.27 cm [95% confidence interval (95% CI), -0.42 to -0.11] from baseline to 9 months, when 99% of children had completed treatment, and -0.43 cm (95% CI, -0.77 to -0.09) during 34 months of follow-up. Similar differences in weight gain were not statistically significant. Although succimer lowers blood lead in moderately lead-poisoned children, it does not have a beneficial effect on growth and may have an adverse effect.Other Research Uni

The Tokyo War Crimes Trial, 1946-1948: The Case for the Defense

Between April 29, 1946 and November 12, 1948 the International Military Tribunal for the Far East convened in Tokyo to try twenty-eight Japanese prewar and wartime leaders accused of war crimes. Eleven Allied countries formed the Tribunal. The International Military Tribunal for the Far East sentenced seven Japanese to death, sixteen to life imprisonment terms and two to terms of seven and sixteen years imprisonment. The primary problem with the Tokyo War Crimes Trial was the nature of the charges against the Japanese accused. Some of the defendants were certainly guilty of the alleged violations of the laws of war. The accused, however, were tried not only on conventional war crimes charges, as recognized by international law, but on ex post facto counts which were unnecessary to attain convictions. The charges of Crimes against Peace and Crimes against Humanity had no basis in international law. The outcome and historical judgment of the trial would appear far different had the Japanese been tried only on conventional war crimes charges. Whether one believes the defendants innocent or guilty of war crimes, the International Military Tribunal for the Far East proceedings were hardly a model of impartiality. The rules of trial procedure, the nature of the evidence and the court's bias in favor of the prosecution precluded a fair trial by American standards. The Tokyo Tribunal, for example, admitted hearsay evidence, permitted leading questions and required testimony by affidavit which prevented cross-examination of the witnesses. If defeated American war leaders had faced trial on the Tokyo standard, the outcry would have been enormous