Investigación en matemáticas, economía y ciencias sociales

El resultado de este libro que reune inquietudes académicas en torno a temas tan estudiados como los que están alrededor del maíz, del frijol o del café; y tan contemporáneos como las aplicaciones concretas de las ciencias ya citadas, al estudio de la adopción del comercio electrónico en empresas del sector agroindustrial o, el caso de la generación de biogas o energía eléctrica por medio de biodigestores. Al editar este texto e incorporarlo a la bibliografía de los temas de referencia, se enriquecen opciones de consulta para los estudiosos de esos temas en general; pero también para interesados en aspectos tan específicos como la cadena de suministro del mercado hortofrutícola en Texcoco

La actuación administrativa direccionada por los principios de la eficacia y la coordinación administrativa: la clave para la realización del interés general

En el siguiente trabajo, se busca analizar como las inconsistencias y omisiones en las actuaciones de las autoridades de Policía no corresponden al principio de la eficacia administrativa ya que no garantizan la seguridad ciudadana por la falta de interlocución y espacios propositivos y de discusión con los habitantes del Barrio Bosa Los Laureles. Para ellos se parte de las denuncias y los testimonios presentados en el Centro de Atención Inmediata de la Policía (CAI) por los Habitantes del Barrio Bosa Los Laureles a causa de los episodios de violencia generada por las Barras Bravas de Marzo a Julio del 2011. El interrogante, al cual en el desarrollo de este trabajo se busca darle respuesta es sí ¿Mediante la Intervención Estatal y como consecuencia del principio de Eficacia Administrativa realmente se garantiza el bienestar ciudadano de los habitantes de Bosa Los Laureles? Para encontrar la respuesta de esta pregunta se busca que mediante una nueva orientación metodológica por parte de las Autoridades de Policía, que interactuando activamente con la comunidad y mediante la aplicación del Principio de la Eficacia Administrativa, estas consoliden el desarrollo de los Fines Esenciales del Estado, la Paz, la Seguridad Ciudadana y la Convivencia Pacífica en el Barrio Bosa Los Laureles

Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

BACKGROUND: In the course of adult hippocampal neurogenesis most regulation takes place during the phase of doublecortin (DCX) expression, either as pro-proliferative effect on precursor cells or as survival-promoting effect on postmitotic cells. We here obtained quantitative data about the proliferative population and the dynamics of postmitotic dendrite development during the period of DCX expression. The question was, whether any indication could be obtained that the initiation of dendrite development is timely bound to the exit from the cell cycle. Alternatively, the temporal course of morphological maturation might be subject to additional regulatory events. RESULTS: We found that (1) 20% of the DCX population were precursor cells in cell cycle, whereas more than 70% were postmitotic, (2) the time span until newborn cells had reached the most mature stage associated with DCX expression varied between 3 days and several weeks, (3) positive or negative regulation of precursor cell proliferation did not alter the pattern and dynamics of dendrite development. Dendrite maturation was largely independent of close contacts to astrocytes. CONCLUSION: These data imply that dendrite maturation of immature neurons is initiated at varying times after cell cycle exit, is variable in duration, and is controlled independently of the regulation of precursor cell proliferation. We conclude that in addition to the major regulatory events in cell proliferation and selective survival, additional micro-regulatory events influence the course of adult hippocampal neurogenesis

Importancia de la Responsabilidad Social y Empresarial para el Aprovechamiento de los Residuos en la Elaboración de Estructuras Metálicas

En esta actividad final se consolida los procesos de aprendizajes que han generado en cada una de las guías de trabajo establecidas de esta forma se implementaran las estrategias dadas a conocer por los punto expuestos por la escuela de ciencias económicas y contables, en las guías y sus actividades, el grupo de trabajo 23 ha seleccionado una micro empresa, para la construcción que tiene como nombre soluciones mecánicas técnicas y diseño sas, la cual busca una mayor penetración en el mercado aprovechando la aceptación que se tiene en el medio de la construcción generando métodos innovadores en el área de estructuras metálicas con el fin de generar cumplimiento en los procesos y normas que hacen referencia a la responsabilidad social y empresarial. Ahora bien, esto permite tener en conocimiento exacto que se requiere para la elaboración de un proyecto que cumpla con las características idóneas requeridas para presentar este trabajo con proyecto final de graduación, es importante destacar que cada una de las actividades desarrolladas permitió el consolidado éxito de la actividad unidad 9 y 10 fase 5. Desde el principio del diplomado se buscó en consolidado de los ítems que hacen referente a la responsabilidad social y empresarial.In this final activity, the learning processes that have been generated in each of the established work guides are consolidated. In this way, the strategies made known by the points presented by the national open and distance university in the activity guides will be implemented, the working group 23 has selected a micro company, for construction whose name is technical mechanical solutions and design sas, which seeks greater penetration in the market taking advantage of the acceptance that exists in the construction environment, generating innovative methods in the area of metal structures in order to generate compliance in the processes and standards that refer to social and business responsibility. Now, this allows us to have exact knowledge of what is required for the development of a project that meets the ideal characteristics required to present this work with a final graduation project. It is important to highlight that each of the activities developed allowed the consolidated success of the activity unit 9 and 10 phase 5. From the beginning of the diploma, a consolidated search was made for the items that refer to social and business responsibility

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio

Human olfactory neural progenitor cells reveal differences in IL-6, IL-8, thrombospondin-1, and MCP-1 in major depression disorder and borderline personality disorder

BackgroundDiscovering biological markers is essential for understanding and treating mental disorders. Despite the limitations of current non-invasive methods, neural progenitor cells from the olfactory epithelium (hNPCs-OE) have been emphasized as potential biomarker sources. This study measured soluble factors in these cells in Major Depressive Disorder (MDD), Borderline Personality Disorder (BPD), and healthy controls (HC).MethodsWe assessed thirty-five participants divided into MDD (n=14), BPD (n=14), and HC (n=7). MDD was assessed using the Hamilton Depression Rating Scale. BPD was evaluated using the DSM-5 criteria and the Structured Clinical Interview for Personality Disorders. We isolated hNPCs-OE, collected intracellular proteins and conditioned medium, and quantified markers and soluble factors, including Interleukin-6, interleukin-8, and others. Analysis was conducted using one-way ANOVA or Kruskal-Wallis test and linear regression.ResultsWe found that hNPCs-OE of MDD and BPD decreased Sox2 and laminin receptor-67 kDa levels. MASH-1 decreased in BPD, while tubulin beta-III decreased in MDD compared to controls and BPD. Also, we found significant differences in IL-6, IL-8, MCP-1, and thrombospondin-1 levels between controls and MDD, or BPD, but not between MDD and BPD.ConclusionsAltered protein markers are evident in the nhNPCs-OE in MDD and BPD patients. These cells also secrete higher concentrations of inflammatory cytokines than HC cells. The results suggest the potential utility of hNPCs-OE as an in vitro model for researching biological protein markers in psychiatric disorders. However, more extensive validation studies are needed to confirm their effectiveness and specificity in neuropsychiatric disorders

The U.S.-Mexico Border Infectious Disease Surveillance Project: Establishing Binational Border Surveillance

In 1997, the Centers for Disease Control and Prevention, the Mexican Secretariat of Health, and border health officials began the development of the Border Infectious Disease Surveillance (BIDS) project, a surveillance system for infectious diseases along the U.S.-Mexico border. During a 3-year period, a binational team implemented an active, sentinel surveillance system for hepatitis and febrile exanthems at 13 clinical sites. The network developed surveillance protocols, trained nine surveillance coordinators, established serologic testing at four Mexican border laboratories, and created agreements for data sharing and notification of selected diseases and outbreaks. BIDS facilitated investigations of dengue fever in Texas-Tamaulipas and measles in California–Baja California. BIDS demonstrates that a binational effort with local, state, and federal participation can create a regional surveillance system that crosses an international border. Reducing administrative, infrastructure, and political barriers to cross-border public health collaboration will enhance the effectiveness of disease prevention projects such as BIDS

Evaluation of the optimal dose of gibberellic acid (Full gib) in the induction of sprouting of yungay potato variety tuber (Solanum tuberosum L.)

This research was carried out in the district of Luya, province of Chachapoyas, Amazonas, with the objective of evaluating the optimal dose of gibberellic acid (Full Gib) in the induction of sprouting of potato tubers (Solanum tuberosum L.) Yungay variety. A Completely Randomized Design (CRD) with two factors three replications and seven treatments was used. Minitat 17 statistical software, ANOVA, and the Tukey mean comparison test at 5% were used for data analysis. The treatments were: Nothing was applied (T1), 7.5 mL of Full Gib in 20 L of water, for 15 min (T2), 7.5 mL of Full Gib in 20 L of water, for 20 min (T3), 10 mL of full Gib in 20 L of water, for 15 min (T4), 10 mL of full Gib in 20 L of water, for 20 min (T5), 12. 5 mL of full Gib in 20 L of water, for 15 min (T6), 12.5 mL of full Gib in 20 L of water, for 20 min (T7). The variables evaluated were: Sprouting percentage, number of sprouts, sprout length, and sprout diameter per tuber. According to the results obtained, it can be observed that treatments 5 and 3 obtained the highest germination percentages with 86.17 and 85.67%, respectively, surpassing the other treatments; there were no significant differences between treatments in the number of sprouts per tuber. Treatments 5, 3, and 4 were better, with results of 8.93, 8.83, and 8.68, respectively; on the other hand, the variable shoot length obtained the best results in treatments 5 and 3 with 7.69 and 7.50 cm, respectively. Similarly, the shoot diameter variable had positive results in treatments 3 and 5 with 6.0 and 5.9 mm, respectively

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

<p>Abstract</p> <p>Background</p> <p>Adult neurogenesis is a particular example of brain plasticity that is partially modulated by the endocannabinoid system. Whereas the impact of synthetic cannabinoids on the neuronal progenitor cells has been described, there has been lack of information about the action of plant-derived extracts on neurogenesis. Therefore we here focused on the effects of Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) fed to female C57Bl/6 and Nestin-GFP-reporter mice on proliferation and maturation of neuronal progenitor cells and spatial learning performance. In addition we used cannabinoid receptor 1 (CB1) deficient mice and treatment with CB1 antagonist AM251 in Nestin-GFP-reporter mice to investigate the role of the CB1 receptor in adult neurogenesis in detail.</p> <p>Results</p> <p>THC and CBD differed in their effects on spatial learning and adult neurogenesis. CBD did not impair learning but increased adult neurogenesis, whereas THC reduced learning without affecting adult neurogenesis. We found the neurogenic effect of CBD to be dependent on the CB1 receptor, which is expressed over the whole dentate gyrus. Similarly, the neurogenic effect of environmental enrichment and voluntary wheel running depends on the presence of the CB1 receptor. We found that in the absence of CB1 receptors, cell proliferation was increased and neuronal differentiation reduced, which could be related to CB1 receptor mediated signaling in Doublecortin (DCX)-expressing intermediate progenitor cells.</p> <p>Conclusion</p> <p>CB1 affected the stages of adult neurogenesis that involve intermediate highly proliferative progenitor cells and the survival and maturation of new neurons. The pro-neurogenic effects of CBD might explain some of the positive therapeutic features of CBD-based compounds.</p

Tree mode of death and mortality risk factors across Amazon forests

The carbon sink capacity of tropical forests is substantially affected by tree mortality. However, the main drivers of tropical tree death remain largely unknown. Here we present a pan-Amazonian assessment of how and why trees die, analysing over 120,000 trees representing &gt; 3800 species from 189 long-term RAINFOR forest plots. While tree mortality rates vary greatly Amazon-wide, on average trees are as likely to die standing as they are broken or uprooted—modes of death with different ecological consequences. Species-level growth rate is the single most important predictor of tree death in Amazonia, with faster-growing species being at higher risk. Within species, however, the slowest-growing trees are at greatest risk while the effect of tree size varies across the basin. In the driest Amazonian region species-level bioclimatic distributional patterns also predict the risk of death, suggesting that these forests are experiencing climatic conditions beyond their adaptative limits. These results provide not only a holistic pan-Amazonian picture of tree death but large-scale evidence for the overarching importance of the growth–survival trade-off in driving tropical tree mortality