Investigating lung responses with functional hyperpolarized xenon-129 MRI in an ex vivo rat model of asthma

Purpose: Asthma is a disease of increasing worldwide importance that calls for new investigative methods. Ex vivo lung tissue is being increasingly used to study functional respiratory parameters independent of confounding systemic considerations but also to reduce animal numbers and associated research costs. In this work, a straightforward laboratory method is advanced to probe dynamic changes in gas inhalation patterns by using an ex vivo small animal ovalbumin (OVA) model of human asthma. Methods: Hyperpolarized (hp)129Xe was actively inhaled by the excised lungs exposed to a constant pressure differential that mimicked negative pleural cavity pressure. The method enabled hp129Xe MRI of airway responsiveness to intravenous methacholine (MCh) and airway challenge reversal through salbutamol. Results: Significant differences were demonstrated between control and OVA challenged animals on global lung hp129Xegas inhalation with P < 0.05 at MCh dosages above 460 µg. Spatial mapping of the regional hp gas distribution revealed an approximately three-fold increase in heterogeneity for the asthma model organs. Conclusion: The experimental results from this proof of concept work suggest that the ex vivo hp noble gas imaging arrangement and the applied image analysis methodology may be useful as an adjunct to current diagnostic techniques

Transformación de la educación preescolar: Diseño curricular para promover aprendizajes significativos en la infancia temprana

The aim of this article was to analyze the importance of curricular planning in fostering meaningful learning in preschool children. A methodology based on bibliographic review and critical analysis of previous research was applied. The results emphasize the need for comprehensive curricular planning that focuses on the holistic development of the child, considering their interests, sociocultural contexts, and developmental stages. The interpretation of these findings highlights the importance of designing inclusive and flexible pedagogical strategies that promote active participation and the construction of meaningful knowledge in children. In conclusion, it is reaffirmed that appropriate curricular planning is essential for enhancing meaningful learning in preschool education.El objetivo de este artículo fue analizar la relevancia de la planificación curricular en la promoción de aprendizajes significativos en niños de educación preescolar. Para ello, se utilizó una metodología basada en la revisión bibliográfica y el análisis crítico de investigaciones previas. Los resultados subrayan la importancia de una planificación curricular integral, que considere el desarrollo holístico del niño, sus intereses, contextos socioculturales y las distintas etapas de su desarrollo. La interpretación de estos hallazgos resalta la necesidad de diseñar estrategias pedagógicas inclusivas y flexibles que favorezcan la participación activa y la construcción de conocimientos significativos en los niños. En conclusión, se reafirma que una planificación curricular adecuada es esencial para potenciar el aprendizaje significativo en la educación preescolar

An alerting structure: Human orexin receptor 1

[No abstract available

Transforming Preschool Education: Curriculum Design to Promote Meaningful Learning in Early Childhood

El objetivo de este artículo fue analizar la relevancia de la planificación curricular en la promoción de aprendizajes significativos en niños de educación preescolar. Para ello, se utilizó una metodología basada en la revisión bibliográfica y el análisis crítico de investigaciones previas. Los resultados subrayan la importancia de una planificación curricular integral, que considere el desarrollo holístico del niño, sus intereses, contextos socioculturales y las distintas etapas de su desarrollo. La interpretación de estos hallazgos resalta la necesidad de diseñar estrategias pedagógicas inclusivas y flexibles que favorezcan la participación activa y la construcción de conocimientos significativos en los niños. En conclusión, se reafirma que una planificación curricular adecuada es esencial para potenciar el aprendizaje significativo en la educación preescolar.The aim of this article was to analyze the importance of curricular planning in fostering meaningful learning in preschool children. A methodology based on bibliographic review and critical analysis of previous research was applied. The results emphasize the need for comprehensive curricular planning that focuses on the holistic development of the child, considering their interests, sociocultural contexts, and developmental stages. The interpretation of these findings highlights the importance of designing inclusive and flexible pedagogical strategies that promote active participation and the construction of meaningful knowledge in children. In conclusion, it is reaffirmed that appropriate curricular planning is essential for enhancing meaningful learning in preschool education