Microscopic approach to pion-nucleus dynamics

Elastic scattering of pions from finite nuclei is investigated utilizing a contemporary, momentum--space first--order optical potential combined with microscopic estimates of second--order corrections. The calculation of the first--order potential includes:\ \ (1)~full Fermi--averaging integration including both the delta propagation and the intrinsic nonlocalities in the $\pi$-$N$ amplitude, (2)~fully covariant kinematics, (3)~use of invariant amplitudes which do not contain kinematic singularities, and (4)~a finite--range off--shell pion--nucleon model which contains the nucleon pole term. The effect of the delta--nucleus interaction is included via the mean spectral--energy approximation. It is demonstrated that this produces a convergent perturbation theory in which the Pauli corrections (here treated as a second--order term) cancel remarkably against the pion true absorption terms. Parameter--free results, including the delta--nucleus shell--model potential, Pauli corrections, pion true absorption, and short--range correlations are presented. (2 figures available from authors)Comment: 13 page

47.4: Blue Phosphorescent Organic Light Emitting Device Stability Analysis

A model based on defect generation by exciton‐polaron annihilation interactions between the emitter and host molecules, in a blue phosphorescent OLED, is shown to fit well with experimental data. A blue PHOLED with (0.15, 0.25) chromaticity is shown to have a half‐life, from 1,000 nits, of 690 hrs.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92134/1/1.3069766.pd

General Survey of Polarization Observables in Deuteron Electrodisintegration

Polarization observables in inclusive and exclusive electrodisintegration of the deuteron using a polarized beam and an oriented target are systematically surveyed using the standard nonrelativistic framework of nuclear theory but with leading order relativistic contributions included. The structure functions and the asymmetries corresponding to the various nucleon polarization components are studied in a variety of kinematic regions with respect to their sensitivity to realistic $NN$-potential models, to subnuclear degrees of freedom in terms of meson exchange currents, isobar configurations and to relativistic effects in different kinematical regions, serving as a benchmark for a test of present standard nuclear theory with effective degrees of freedom.Comment: 56 pages, 32 figures, revtex

Data reduction pipeline for MOF-based synoptic telescopes

There are strong scientific cases and practical reasons for building ground-based solar synoptic telescopes. Some issues, like the study of solar dynamics and the forecasting of solar flares, benefit from the 3D reconstruction of the Sun's atmosphere and magnetic field. Others, like the monitoring and prediction of space weather, require full disk observations, at the proper sampling rate, combining H-alpha images and Doppler velocity and magnetic field. The synoptic telescopes based on Magneto Optical Filters (MOF) using different lines are capable of measuring the line-of-sight Doppler velocity and magnetic field over the full solar disk at different ranges of height in the Sun's photosphere and low chromosphere. Instruments like the MOTH (Magneto-Optical filters at Two Heights), using a dual-channel based on MOFs operating at 589.0 nm (Na D2 line) and 769.9 nm (K D1 line), the VAMOS instrument (Velocity And Magnetic Observations of the Sun), operating at 769.9 nm (K D1 line), and the future TSST (Tor Vergata Synoptic Solar Telescope), using a dual-channel telescope operating at 656.28 nm (H-alpha line) and at 769.9 nm (K D1 line), allow to face both aspects, the scientific and the operative related to Space Weather applications. The MOTH, VAMOS and TSST data enable a wide variety of studies of the Sun, from seismic probing of the solar interior (sound speed, rotation, details of the tachocline, sub-surface structure of active regions), to the dynamics and magnetic evolution of the lower part of the solar atmosphere (heating of the solar atmosphere, identification of the signatures of solar eruptive events, atmospheric gravity waves, etc.), to the 3D reconstruction of the solar atmosphere and flare locations. However, the use of MOF filters requires special care in calibrating the data for scientific or operational use. This work presents a systematic pipeline that derives from the decennial use of MOF's technology. More in detail, the pipeline is based on data reduction procedures tested and validated on MOTH data acquired at Mees Solar Observatory of the University of Hawaii Haleakala Observatories and at South Pole Solar Observatory (SPSO), at the Amundsen-Scott South Pole Station in Antarctica, during Antarctica Summer Campaign 2016/17

Revisiting the B-cell compartment in mouse and humans: more than one B-cell subset exists in the marginal zone and beyond.

International audienceABSTRACT: The immunological roles of B-cells are being revealed as increasingly complex by functions that are largely beyond their commitment to differentiate into plasma cells and produce antibodies, the key molecular protagonists of innate immunity, and also by their compartmentalisation, a more recently acknowledged property of this immune cell category. For decades, B-cells have been recognised by their expression of an immunoglobulin that serves the function of an antigen receptor, which mediates intracellular signalling assisted by companion molecules. As such, B-cells were considered simple in their functioning compared to the other major type of immune cell, the T-lymphocytes, which comprise conventional T-lymphocyte subsets with seminal roles in homeostasis and pathology, and non-conventional T-lymphocyte subsets for which increasing knowledge is accumulating. Since the discovery that the B-cell family included two distinct categories - the non-conventional, or extrafollicular, B1 cells, that have mainly been characterised in the mouse; and the conventional, or lymph node type, B2 cells - plus the detailed description of the main B-cell regulator, FcγRIIb, and the function of CD40+ antigen presenting cells as committed/memory B-cells, progress in B-cell physiology has been slower than in other areas of immunology. Cellular and molecular tools have enabled the revival of innate immunity by allowing almost all aspects of cellular immunology to be re-visited. As such, B-cells were found to express "Pathogen Recognition Receptors" such as TLRs, and use them in concert with B-cell signalling during innate and adaptive immunity. An era of B-cell phenotypic and functional analysis thus began that encompassed the study of B-cell microanatomy principally in the lymph nodes, spleen and mucosae. The novel discovery of the differential localisation of B-cells with distinct phenotypes and functions revealed the compartmentalisation of B-cells. This review thus aims to describe novel findings regarding the B-cell compartments found in the mouse as a model organism, and in human physiology and pathology. It must be emphasised that some differences are noticeable between the mouse and human systems, thus increasing the complexity of B-cell compartmentalisation. Special attention will be given to the (lymph node and spleen) marginal zones, which represent major crossroads for B-cell types and functions and a challenge for understanding better the role of B-cell specificities in innate and adaptive immunology

Fair Play Game::a group contingency strategy to increase students' active behaviours in physical education

A dependent group contingency strategy called Fair Play Game was applied to promote increase in number of steps during physical education classes for sixth-grade students. Results from a multiple baseline design across three classes showed that the mean number of steps for baseline vs. intervention were: Class 1: 43 vs. 64 steps/minute; Class 2: 49 vs. 81 steps/minute; Class 3: 50 vs. 87 steps/minute. Visual inspection of the graphs showed that Class 1 had an upward trend of number of steps (baseline vs. intervention) without a change in level. Classes 2 and 3 demonstrated clearer change in level of number of steps between these two phases. Social validity data showed that students increased their engagement in class and Fair Play Game is a feasible and acceptable strategy. Therefore, it can be concluded that Fair Play Game appeared to be associated with students' increase in active behaviours in physical education lessons

Mesonic cloud contribution to the nucleon and delta masses

Pion-nucleon elastic scattering in the dominant $P_{33}$ channel is examined in the model in which the interaction is of the form $\pi + N\leftrightarrow N, \Delta(1232)$. New expressions are found for the elastic pion-nucleon scattering amplitude which differ from existing formula both in the kinematics and in the treatment of the renormalization of the nucleon mass and coupling constant. Fitting the model to the phase shifts in the $P_{33}$ channel does not uniquely fix the parameters of the model. The cutoff for the pion-nucleon form factor is found to lie in the range $\beta = 750\pm350$ MeV/c. The masses of the nucleon and the $\Delta$ which would arise if there were no coupling to mesons are found to be $m_{_N}^{(0)}= 1200\pm 200$ MeV and $m_\Delta^{(0)} = 1500\pm 200$ MeV. The difference in these bare masses, a quantity which would be accounted for by a residual gluon interaction, is found to be $\delta m^{(0)}=350\pm 100$ MeV.Comment: 26 pages, 9 figures, significant rewrit

Maternal Immunization with Pneumococcal Surface Protein A Protects against Pneumococcal Infections among Derived Offspring

Pathogen-specific antibody plays an important role in protection against pneumococcal carriage and infections. However, neonates and infants exhibit impaired innate and adaptive immune responses, which result in their high susceptibility to pneumococci. To protect neonates and infants against pneumococcal infection it is important to elicit specific protective immune responses at very young ages. In this study, we investigated the protective immunity against pneumococcal carriage, pneumonia, and sepsis induced by maternal immunization with pneumococcal surface protein A (PspA). Mother mice were intranasally immunized with recombinant PspA (rPspA) and cholera toxin B subunit (CTB) prior to being mated. Anti-PspA specific IgG, predominantly IgG1, was present at a high level in the serum and milk of immunized mothers and in the sera of their pups. The pneumococcal densities in washed nasal tissues and in lung homogenate were significantly reduced in pups delivered from and/or breast-fed by PspA-immunized mothers. Survival after fatal systemic infections with various types of pneumococci was significantly extended in the pups, which had received anti-PspA antibody via the placenta or through their milk. The current findings strongly suggest that maternal immunization with PspA is an attractive strategy against pneumococcal infections during early childhood. (191 words

Antisera Against Certain Conserved Surface-Exposed Peptides of Nontypeable Haemophilus influenzae Are Protective

We thank Timothy VanWagoner for bioinformatics support, Huda Mussa for assistance with sequencing and Brett Cole for assistance with animal studies. We thank Arnold Smith for inspiration and persistence in understanding the basic biology of H. flu..The authors gratefully acknowledge the Children’s Hospital Foundation for promoting the Department of Pediatrics Research Infrastructure. The Foundation provided no financial support for this specific project.Nontypeable Haemophilus influenzae (NTHi) cause significant disease, including otitis media in children, exacerbations of chronic obstructive pulmonary disease, and invasive disease in susceptible populations. No vaccine is currently available to prevent NTHi disease. The interactions of NTHi and the human host are primarily mediated by lipooligosaccharide and a complex array of surface-exposed proteins (SEPs) that act as receptors, sensors and secretion systems. We hypothesized that certain SEPs are present in all NTHi strains and that a subset of these may be antibody accessible and represent protective epitopes. Initially we used 15 genomic sequences available in the GenBank database along with an additional 11 genomic sequences generated by ourselves to identify the core set of putative SEPs present in all strains. Using bioinformatics, 56 core SEPs were identified. Molecular modeling generated putative structures of the SEPs from which potential surface exposed regions were defined. Synthetic peptides corresponding to ten of these highly conserved surface-exposed regions were used to raise antisera in rats. These antisera were used to assess passive protection in the infant rat model of invasive NTHi infection. Five of the antisera were protective, thus demonstrating their in vivo antibody accessibility. These five peptide regions represent potential targets for peptide vaccine candidates to protect against NTHi infection.Yeshttp://www.plosone.org/static/editorial#pee