Immediate and delayed hypersensitivity reactions to a single dose of oxaliplatin

Hypersensitivity reaction (HSR), occurring during or immediately after oxaliplatin infusions are well documented and occur more commonly after multiple courses of therapy.A 69-year-old white woman with Stage Ill colon cancer commenced adjuvant chemotherapy with oxaliplatin and capecitabine. Ten minutes after the completion of the oxaliplatin infusion she experienced a severe hypersensitivity reaction. Symptoms resolved after treatment With corticosteroids, antihistamines, and bronchodilators. Nineteen hours later, a similar reaction Occurred.A review of the literature found 2 similar cases of delayed reactions to oxaliplatin occurring 20 and 10 hours after infusion, respectively. The first case occurred after the initial dose and again with cycle 2. The second case happened after the sixth infusion.This is the first reported case, to our knowledge, of immediate and delayed hypersensitivity reactions occurring after the initial dose of oxaliplatin

Building Level Principals\u27 Roles in Special Education Teacher Retention

Attrition of special education teachers has steadily increased. The number of general education teachers that left teaching in 1991-1992 was 5.2% and in 2000-2001, it was 7.1%. Special education teachers followed the same upward trend but had an even more significant increase, in 1991-1992, it was 4.9% and in 2000-2001, it was 8.7%. The rate for general education teachers increased approximately 2% and the rate for special education teachers almost doubled (Boe, Cook, & Sunderland, 2008). There are numerous reasons for special education teacher attrition. For purposes of this paper, I will look at specific variables related to work environment that the building principal can control. These factors are school climate, administrative support, colleague support, mentoring, and professional development

Principals\u27 Leadership and Teachers\u27 Motivation : A Study of the Relationship in the School Reform Era

This study investigated the relationship between principal leadership behaviors and the level of teacher motivation in a specific region of Virginia, within school divisions that have at least one elementary school designated as a focus school. This study will examine whether the relationship between leadership and motivation differs in elementary schools classified as focus, in-improvement and those with no designation as defined by the flexibility waiver received by Virginia Department of Education. Of particular interest are the specific principal behaviors within each leadership style that support increased levels of motivation in elementary teachers. This study was relevant because there were increased accountability measures pertaining to student achievement for public schools due to the federal mandates from No Child Left Behind Legislation (2002), and the revised ESEA waiver (2012). This study found that teachers’ perceptions of principals’ transformational behaviors were more correlated to the level of their motivation than the self-reported behaviors by principals. This study also found that the principals employed in focus schools were more likely to report increased transformational behaviors than their counterparts at in-improvement and no designation schools

Fault tolerant and integrated token ring network

This thesis is a study of communication protocols (token ring, FDDI, and ISDN), microcontrollers (68HC 1EVB), and fault tolerance schemes. One of the major weaknesses of the token ring network is that if a single station fails, the entire system fails. A scheme involving a combination of hardware and timer interrupts in the software has been designed and implemented which deals with this risk. Software and protocols have been designed and applied to the network to reduce the chance of bit faults in communications. ISDN frame format proved to be exceptional in its capacity to carry echoed data and a large variety of tokens which could be used by the stations to test the data. By its very nature, the token ring supplied another major fault detection device by allowing the data to be returned and tested at its source. The resulting network was successful

Deciding Together?:Best Interests and Shared Decision-Making in Paediatric Intensive Care

In the western healthcare, shared decision making has become the orthodox approach to making healthcare choices as a way of promoting patient autonomy. Despite the fact that the autonomy paradigm is poorly suited to paediatric decision making, such an approach is enshrined in English common law. When reaching moral decisions, for instance when it is unclear whether treatment or non-treatment will serve a child’s best interests, shared decision making is particularly questionable because agreement does not ensure moral validity. With reference to current common law and focusing on intensive care practice, this paper investigates what claims shared decision making may have to legitimacy in a paediatric intensive care setting. Drawing on key texts, I suggest these identify advantages to parents and clinicians but not to the child who is the subject of the decision. Without evidence that shared decision making increases the quality of the decision that is being made, it appears that a focus on the shared nature of a decision does not cohere with the principle that the best interests of the child should remain paramount. In the face of significant pressures toward the displacement of the child’s interests in a shared decision, advantages of a shared decision to decisional quality require elucidation. Although a number of arguments of this nature may have potential, should no such advantages be demonstrable we have cause to revise our commitment to either shared decision making or the paramountcy of the child in these circumstances

Exploring Gender-Based Toxic Speech on Twitter in Context of the #MeToo movement: A Mixed Methods Approach

The #MeToo movement has catalyzed widespread public discourse surrounding sexual harassment and assault, empowering survivors to share their stories and holding perpetrators accountable. While the movement has had a substantial and largely positive influence, this study aims to examine the potential negative consequences in the form of increased hostility against women and men on the social media platform Twitter. By analyzing tweets shared between October 2017 and January 2020 by more than 47.1k individuals who had either disclosed their own sexual abuse experiences on Twitter or engaged in discussions about the movement, we identify the overall increase in gender-based hostility towards both women and men since the start of the movement. We also monitor 16 pivotal real-life events that shaped the #MeToo movement to identify how these events may have amplified negative discussions targeting the opposite gender on Twitter. Furthermore, we conduct a thematic content analysis of a subset of gender-based hostile tweets, which helps us identify recurring themes and underlying motivations driving the expressions of anger and resentment from both men and women concerning the #MeToo movement. This study highlights the need for a nuanced understanding of the impact of social movements on online discourse and underscores the importance of addressing gender-based hostility in the digital sphere

Witnessing Parental Violence and Cyber IPV Perpetration in Hispanic Emerging Adults: The Mediating Role of Attitudes Toward IPV

Recent studies indicate that the perpetration of intimate partner violence via cyberspaces (cyber IPV), namely, psychological aggression, sexual aggression, and cyberstalking is high among emerging adults. However, little is known of the risk factors that lead to cyber IPV and far lesser within Hispanic adults. Based on the intergenerational transmission of violence hypothesis, the present study examined the indirect effect of witnessing parental violence during childhood on the three types of cyber IPV through attitudes condoning IPV in Hispanic men and women, separately. Participants were 1,136 Hispanic emerging adults in the age range of 18-29 years (M = 20.53 years, SD = 2.42; 72.5% women, 88% Mexican descent). Over half of the participants (54.2%) witnessed at least one instance of parental violence during childhood. In contrast to women, men were more likely to hold attitudes accepting of IPV and perpetrate cyber sexual IPV, whereas women were more likely to report cyberstalking perpetration. Men and women with exposure to mother-to-father violence held attitudes justifying IPV that was associated with perpetrating the three cyber IPV types in adulthood (women: Brange = .016-.036; men: Brange = .016-.024). No significant gender differences were found in the associations of mother-to-father WPV and father-to-mother WPV on the three types of cyber IPV perpetration. These findings are discussed in the context of Hispanic culture, which has specific implications for cyber IPV intervention strategies

Meta-Analysis of Cyber Intimate Partner Violence Perpetration and Victimization: Different Types and their Associations with Face-to-Face IPV among Men and Women

Cyber intimate partner violence (C-IPV) is a technology-mediated form of violence. It has been examined only in the last 10 years as a form of violence that can cause psychological damage to its victims. How this phenomenon connects to and differs from face-to-face IPV (F2F-IPV) has been, as yet, little studied. Research has not made clear whether sex differences may impact its use, particularly in light of the fact that no physical coercion is used in C-IPV. Thus, the current research aimed to investigate through a meta-analysis: differences between the average levels of different types of C-IPV victimization and perpetration; the association between C-IPV and F2F-IPV victimization and perpetration; and whether the answers to these questions were dependent on sex. The current meta-analysis drew on 46 studies, within 44 papers, with a total sample of 27,491 participants. Findings from 22 of these studies showed no significant sex differences between the average levels of different types of C-IPV victimization and between different types of C-IPV perpetration. These 22 studies showed positive large effect sizes for the correlation between C-IPV and F2F-IPV perpetration and victimization. Moreover, in both perpetration and victimization, sex did not impact the level of association. The findings suggested that C-IPV and F2F-IPV are highly correlated, and though not the same, they may share similar characteristics. Additionally, the results suggested that sex differences do not impact non-physical aggression, such as C-IPV. The implications for preventive strategies include that IPV interventions should also focus on alleviating instances of C-IPV

Limitations and pitfalls of using family letters to communicate genetic risk: a qualitative study with patients and healthcare professionals

European genetic testing guidelines recommend that healthcare professionals (HCPs) discuss the familial implications of any test with a patient and offer written material to help them share the information with family members. Giving patients these “family letters” to alert any relatives of their risk has become part of standard practice and has gone relatively unquestioned over the years. Communication with at-risk relatives will become an increasingly pressing issue as mainstream and routine practice incorporates broad genome tests and as the number of findings potentially relevant to relatives increases. This study therefore explores problems around the use of family letters to communicate about genetic risk. We conducted 16 focus groups with 80 HCPs, and 35 interviews with patients, recruited from across the UK. Data were analyzed thematically and we constructed four themes: 1) HCPs writing family letters: how to write them and why?, 2) Patients’ issues with handing out family letters, 3) Dissemination becomes an uncontrolled form of communication, and 4) When the relative has the letter, is the patient’s and HCP’s duty discharged? We conclude by suggesting alternative and supplementary methods of communication, for example through digital tools, and propose that in comparison to communication by family letter, direct contact by HCPs might be a more appropriate and successful option