Process Evaluation of Community Energy Development Programme Projects

This report sets out the findings, conclusions and recommendations of a Process Evaluation, conducted between January and March 2015, of the Community Energy Development Programme (CEDP) projects as part of the Malawi Renewable Energy Acceleration Programme (MREAP). It was commissioned by the Scottish Government (SG) as a product of the Institutional Support Programme Component (ISP) of MREAP. Its main purpose is to assess what has been delivered, how this has been achieved and to compile learning from the process for policy and future projects. The agreed scope for the process evaluation was the portfolio of 46 CEDP projects implemented across the 3 regions of Malawi and the relevant processes and systems in place to design, implement and manage these projects. Due consideration was also given to framing the scope of the evaluation through the choice of evaluation questions and the feasibility of what was possible

Data Reduction Pipeline for the CHARIS Integral-Field Spectrograph I: Detector Readout Calibration and Data Cube Extraction

We present the data reduction pipeline for CHARIS, a high-contrast integral-field spectrograph for the Subaru Telescope. The pipeline constructs a ramp from the raw reads using the measured nonlinear pixel response, and reconstructs the data cube using one of three extraction algorithms: aperture photometry, optimal extraction, or $\chi^2$ fitting. We measure and apply both a detector flatfield and a lenslet flatfield and reconstruct the wavelength- and position-dependent lenslet point-spread function (PSF) from images taken with a tunable laser. We use these measured PSFs to implement a $\chi^2$-based extraction of the data cube, with typical residuals of ~5% due to imperfect models of the undersampled lenslet PSFs. The full two-dimensional residual of the $\chi^2$ extraction allows us to model and remove correlated read noise, dramatically improving CHARIS' performance. The $\chi^2$ extraction produces a data cube that has been deconvolved with the line-spread function, and never performs any interpolations of either the data or the individual lenslet spectra. The extracted data cube also includes uncertainties for each spatial and spectral measurement. CHARIS' software is parallelized, written in Python and Cython, and freely available on github with a separate documentation page. Astrometric and spectrophotometric calibrations of the data cubes and PSF subtraction will be treated in a forthcoming paper.Comment: 18 pages, 15 figures, 3 tables, replaced with JATIS accepted version (emulateapj formatted here). Software at https://github.com/PrincetonUniversity/charis-dep and documentation at http://princetonuniversity.github.io/charis-de

The value of qualitative longitudinal research for researchers and policy makers : lessons learnt from exploring long-term impacts of flooding

ACKNOWLEDGEMENTS Research reported in this paper was funded by an award from Scotland’s Centre of Expertise for Waters. For the purposes of open access, the author has applied a Creative Commons Attribution (CC BY) [or other appropriate licence] licence to any Author Accepted Manuscript version arising from this submission.Peer reviewedPublisher PD

Novel analgesic interventions in cancer-induced bone pain

Cancer-induced bone pain (CIBP), due to bony metastases, is a major clinical problem, significantly reducing quality of life in cancer patients. Current therapies often provide inadequate analgesia or unacceptable side effects. The aim of this thesis was to characterise behaviours of a preclinical model of CIBP and test novel analgesic interventions in this model. A secondary aim was to investigate the involvement of the N-methyl-D-Aspartate (NMDA) receptors and TRP channels (TRPM8, TRPV1 and TRPV4) in CIBP. Investigation of CIBP in a preclinical model may lead to better pain management in CIBP patients. The results presented here demonstrate that this model of CIBP develops behaviours that may be indicative of mechanical allodynia, thermal sensitivity, movement-evoked pain, ongoing pain and spontaneous pain. This suggests that this model reflects the clinical condition of CIBP, where patients suffer from constant background pain with spontaneous and movement-related breakthrough pain. In this study it was found that radiotherapy significantly attenuated movement-evoked pain and thermal sensitivity to 20°C and 40°C. XRT also significantly reduced anxiety and risk assessment behaviours (grooming behaviour and number of protected stretch attends) compared to untreated CIBP. Duloxetine attenuated CIBP-induced mechanical allodynia, thermal sensitivity to 40°C and movement-evoked pain, whereas S,S-reboxetine attenuated thermal sensitivity to 40°C but did not effect CIBP-induced mechanical allodynia or movement-evoked pain. In addition, CB 65 attenuated movement-evoked pain and thermal sensitivity to 40°C. A single dose of gabapentin did not attenuate CIBP-induced mechanical allodynia, thermal sensitivity to 40°C or movement-evoked pain. These studies confirm that the CIBP model shows characteristics and pharmacological sensitivities consistent with known and predicted mechanisms and validate it as a useful model for assessing potential new treatments proposed for use in patients. Behavioural results suggest that NMDA receptors containing the NR2A subunit are involved in CIBP-induced movement-evoked pain. This suggests that NR2A antagonists may be useful for treating CIBP-induced movement-evoked pain. Additionally, results show that there is increased expression of NR2A in the laminae I, II and III in the dorsal horn of the spinal cord. XRT treated animals also showed increased expression of NR2A in laminae I and II. The selective involvement of NR2A in CIBP is different to other chronic pain states, for example, neuropathic pain states that appear to involve the NR2B subunit. The TRPV1 antagonist AMG 9810 did not attenuate mechanical allodynia, thermal sensitivity to 40°C or movement-evoked pain. Interestingly, the TRPM8 agonist icilin attenuated movement-evoked pain, which suggests that icilin might be useful in the treatment of movement-evoked pain. The TRPV4 antagonist RN 1734 attenuated mechanical allodynia, thermal sensitivity to 40°C and movement-evoked pain in CIBP. This suggests RN 1734 may be useful in the treatment of mechanical allodynia, thermal sensitivity to 40°C and movement-evoked pain in CIBP. Results show that the expression of TRPV4 is increased in DRG ipsilateral to the cancerbearing tibia. In conclusion, these results show that the preclinical model of CIBP investigated in this thesis is suitable for testing novel analgesic interventions. This thesis identified some useful targets for the analgesic treatment of CIBP and results suggest that many different mechanisms contribute to CIBP. A point to consider is that any robust effective treatment may need to target all (or at least several) of these mechanisms

First light of the CHARIS high-contrast integral-field spectrograph

One of the leading direct Imaging techniques, particularly in ground-based imaging, uses a coronagraphic system and integral field spectrograph (IFS). The Coronagraphic High Angular Resolution Imaging Spectrograph (CHARIS) is an IFS that has been built for the Subaru telescope. CHARIS has been delivered to the observatory and now sits behind the Subaru Coronagraphic Extreme Adaptive Optics (SCExAO) system. CHARIS has ‘high’ and ‘low’ resolution operating modes. The high-resolution mode is used to characterize targets in J, H, and K bands at R70. The low-resolution prism is meant for discovery and spans J+H+K bands (1.15-2.37 microns) with a spectral resolution of R18. This discovery mode has already proven better than 15-sigma detections of HR8799c,d,e when combining ADI+SDI. Using SDI alone, planets c and d have been detected in a single 24 second image. The CHARIS team is optimizing instrument performance and refining ADI+SDI recombination to maximize our contrast detection limit. In addition to the new observing modes, CHARIS has demonstrated a design with high robustness to spectral crosstalk. CHARIS has completed commissioning and is open for science observations

Remodelling of human atrial K+ currents but not ion channel expression by chronic β-blockade

Chronic β-adrenoceptor antagonist (β-blocker) treatment in patients is associated with a potentially anti-arrhythmic prolongation of the atrial action potential duration (APD), which may involve remodelling of repolarising K+ currents. The aim of this study was to investigate the effects of chronic β-blockade on transient outward, sustained and inward rectifier K+ currents (ITO, IKSUS and IK1) in human atrial myocytes and on the expression of underlying ion channel subunits. Ion currents were recorded from human right atrial isolated myocytes using the whole-cell-patch clamp technique. Tissue mRNA and protein levels were measured using real time RT-PCR and Western blotting. Chronic β-blockade was associated with a 41% reduction in ITO density: 9.3 ± 0.8 (30 myocytes, 15 patients) vs 15.7 ± 1.1 pA/pF (32, 14), p < 0.05; without affecting its voltage-, time- or rate dependence. IK1 was reduced by 34% at −120 mV (p < 0.05). Neither IKSUS, nor its increase by acute β-stimulation with isoprenaline, was affected by chronic β-blockade. Mathematical modelling suggested that the combination of ITO- and IK1-decrease could result in a 28% increase in APD90. Chronic β-blockade did not alter mRNA or protein expression of the ITO pore-forming subunit, Kv4.3, or mRNA expression of the accessory subunits KChIP2, KChAP, Kvβ1, Kvβ2 or frequenin. There was no reduction in mRNA expression of Kir2.1 or TWIK to account for the reduction in IK1. A reduction in atrial ITO and IK1 associated with chronic β-blocker treatment in patients may contribute to the associated action potential prolongation, and this cannot be explained by a reduction in expression of associated ion channel subunits

Direct Imaging Search for Extrasolar Planets in the Pleiades

We carried out an imaging survey for extrasolar planets around stars in the Pleiades (125 Myr, 135 pc) in the $H$ and $K_{S}$ bands using HiCIAO combined with the adaptive optics, AO188, on the Subaru telescope. We found 13 companion candidates fainter than 14.5 mag in the $H$ band around 9 stars. Five of these 13 were confirmed to be background stars by measurement of their proper motion. One was not found in the second epoch observation, and thus was not a background or companion object. One had multi-epoch image, but the precision of its proper motion was not sufficient to conclude whether it was background object. Four other candidates are waiting for second epoch observations to determine their proper motion. Finally, the remaining 2 were confirmed to be 60 $M_{J}$ brown dwarf companions orbiting around HD 23514 (G0) and HII 1348 (K5) respectively, as had been reported in previous studies. In our observations, the average detection limit for a point source was 20.3 mag in the $H$ band beyond 1''.5 from the central star. On the basis of this detection limit, we calculated the detection efficiency to be 90% for a planet with 6 to 12 Jovian masses and a semi-major axis of 50--1000 AU. For this we extrapolated the distribution of planet mass and semi-major axis derived from RV observations and adopted the planet evolution model of Baraffe et al. (2003). As there was no detection of a planet, we estimated the frequency of such planets to be less than 17.9% ($2\sigma$) around one star of the Pleiades cluster.Comment: 30 pages, 5 figures, accepted for publication in PAS