Roturas agudas de L.C.A. de la rodilla: refuerzo con cordón RD.S

Se presenta la técnica de reconstrucción en las roturas agudas del L.C.A. mediante reparación con cordón de P.D.S., así como los criterios seguidos por los autores ante las roturas agudas de dicho ligamento. Expone una casuística de 24 intervenciones, con un seguimiento de 1.5 años, sin haber encontrado complicaciones destacables y con un 75% de Muy Buenos Resultados y un 25% de Buenos Resultados.The technique used in the repair of acute rupture of the ACL with a band of PDS, together with the criteria followed by our department in such cases both acute are decribed. The describe 24 operations performed by them, with a follow-up of 1.5 years, with no major complications, 75% excellent results and 25% good results

Determinism and causative factors for morphological anomalies in reared European fishes

The presence of sublethal morphological deformities represents one of the main bottleneck of the industrial finfish hatchery production, resulting in major economic loss due to reduced growth and marketing ability of the final product, that has to be transformed (filets) or sold for fish flour. Furthermore, the elimination of deformed fishes from the productive cycle needs for periodic selections at present carried out by manual sorting. This represents an additional economic cost, and a stress for fishes

Oral chondroitin sulfate and prebiotics for the treatment of canine Inflammatory Bowel Disease: a randomized, controlled clinical trial

BACKGROUND Canine inflammatory bowel disease (IBD) is a chronic enteropathy of unknown etiology, although microbiome dysbiosis, genetic susceptibility, and dietary and/or environmental factors are hypothesized to be involved in its pathogenesis. Since some of the current therapies are associated with severe side effects, novel therapeutic modalities are needed. A new oral supplement for long-term management of canine IBD containing chondroitin sulfate (CS) and prebiotics (resistant starch, β-glucans and mannaoligosaccharides) was developed to target intestinal inflammation and oxidative stress, and restore normobiosis, without exhibiting any side effects. This double-blinded, randomized, placebo-controlled trial in dogs with IBD aims to evaluate the effects of 180 days administration of this supplement together with a hydrolyzed diet on clinical signs, intestinal histology, gut microbiota, and serum biomarkers of inflammation and oxidative stress. RESULTS Twenty-seven client-owned biopsy-confirmed IBD dogs were included in the study, switched to the same hydrolyzed diet and classified into one of two groups: supplement and placebo. Initially, there were no significant differences between groups (p > 0.05) for any of the studied parameters. Final data analysis (supplement: n = 9; placebo: n = 10) showed a significant decrease in canine IBD activity index (CIBDAI) score in both groups after treatment (p < 0.001). After treatment, a significant decrease (1.53-fold; p < 0.01) in histologic score was seen only in the supplement group. When groups were compared, the supplement group showed significantly higher serum cholesterol (p < 0.05) and paraoxonase-1 (PON1) levels after 60 days of treatment (p < 0.01), and the placebo group showed significantly reduced serum total antioxidant capacity (TAC) levels after 120 days (p < 0.05). No significant differences were found between groups at any time point for CIBDAI, WSAVA histologic score and fecal microbiota evaluated by PCR-restriction fragment length polymorphism (PCR-RFLP). No side effects were reported in any group. CONCLUSIONS The combined administration of the supplement with hydrolyzed diet over 180 days was safe and induced improvements in selected serum biomarkers, possibly suggesting a reduction in disease activity. This study was likely underpowered, therefore larger studies are warranted in order to demonstrate a supplemental effect to dietary treatment of this supplement on intestinal histology and CIBDAI

Feeding regimes affected the circadian rhythms of pancreatic digestive enzymes and somatic growth in flathead grey mullet (Mugil cephalus) fry

The effect of different feeding regimes on the circadian rhythms of pancreatic digestive enzyme activities was evaluated in Mugil cephalus fry weighting 0.34 ± 0.01 g. Feeding regimes (feeding ration = 3% stocked biomass) differed on the number of meals offered per day: one, two and ten meals per day (R1, R2 and R3, respectively). The number of meals per day affected somatic growth; in particular, fry from the R3 group (0.80 ± 0.01 g) grew better than their congeners from R2 (0.70 ± 0.01 g) and R1 (0.63 ± 0.01 g) groups (P < 0.05). Feeding behaviour was modulated by the feeding regime, being the maximal gut fullness values found just after meal distribution in R1 and R2 groups, whereas this trend was not observed when feed was offered continuously during light hours (R3). Fry from R1 and R2 groups showed hyperphagia as they tended to store in their gut as much as possible feed particles to be later digested due to the limited daily meals. This strategy negatively affected feed digestion due to inappropriate enzyme to substrate ratio, changes in digestive enzyme activities and chyme transit times, which ultimately impaired growth performance. Enzyme activities were modulated by the number of meals, the more frequent the meals offered, the lower enzyme activities, supporting the hypothesis that digestive function is adapted to obtain a maximum benefit of the ingested nutrients. Present results showed that feeding grey mullet fry continuously during day light hours optimized feed digestion and promoted fry growth.info:eu-repo/semantics/acceptedVersio

Improving the managed introduction of new medicines : sharing experiences to aid authorities across Europe

The 3-day course on the managed introduction of new drugs was organised by the Piperska group together with the Agency for Health Technology Assessment and Tariff System (AOTMiT) and WHO Europe to share experiences and case histories among health authority and health insurance company personnel, academics and those from commercial organisations from across Europe on potential ways to optimise the managed entry of new medicines. This starts pre-launch with horizon scanning and budgeting, then peri-launch including critical drug evaluation, and finally post launch including monitoring prescribing of new medicines against agreed guidance and indicators. There were also discussions on issues regarding managed entry schemes and procurement strategies including biosimilars

Estrategias de conservación para Cotoneaster granatensis (Rosaceae), especie catalogada En Peligro de Extinción en la Comunitat Valenciana (España)

Cotoneaster granatensis (Rosaceae) is an endangered species in the Valencian Community with two natural populations known and 37 wild plants located in Alicante province. The strategy applied for conservation of this species comprises three steps in a cyclical method: in situ (first step) - ex situ - in situ (second step). Current conservation status for this species has been evaluated as a part of the first step in situ actions. Ex situ conservation activities consisted of germplasm conservation on seed banks, creation and maintenance of collections of livings plants and production of new plants in order to develop reintroductions (in situ actions: second step) in natural populations. The seed germination is a complex issue, but an effective protocol has been established reaching values over 60% of germination. The plant propagation by cuttings has not been successful. In situ actions such as reducing the threat of herbivory has been also essential to enhance natural populations. The initial results on plantations in the natural habitat show high survival rates of specimens

Transiting exoplanets from the CoRoT space mission VIII. CoRoT-7b: the first Super-Earth with measured radius

We report the discovery of very shallow (DF/F = 3.4 10-4), periodic dips in the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite, which we interpret as due to the presence of a transiting companion. We describe the 3-colour CoRoT data and complementary ground-based observations that support the planetary nature of the companion. Methods. We use CoRoT color information, good angular resolution ground-based photometric observations in- and out- of transit, adaptive optics imaging, near-infrared spectroscopy and preliminary results from Radial Velocity measurements, to test the diluted eclipsing binary scenarios. The parameters of the host star are derived from optical spectra, which were then combined with the CoRoT light curve to derive parameters of the companion. We examine carefully all conceivable cases of false positives, and all tests performed support the planetary hypothesis. Blends with separation larger than 0.40 arcsec or triple systems are almost excluded with a 8 10-4 risk left. We conclude that, as far as we have been exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which we derive a period of 0.853 59 +/- 3 10-5 day and a radius of Rp = 1.68 +/- 0.09 REarth. Analysis of preliminary radial velocity data yields an upper limit of 21 MEarth for the companion mass, supporting the finding. CoRoT-7b is very likely the first Super-Earth with a measured radius.Comment: Accepted in Astronomy and Astrophysics; typos and language corrections; version sent to the printer w few upgrade

Editorial: Physiological Impacts of Global Warming in Aquatic Organisms

Climate change is reshaping our planet.Warming surface waters, acidification, and deoxygenation are the most critical effects of climate change in aquatic environments. Increasing mean water temperatures modify species distribution, alters their basal metabolic rates, the occurrence and intensity of marine diseases, and the timing of pivotal biological events, among others. Ocean acidification results in physiological stress and inhibits the growth and calcification of endo- and exo-skeletons, while ocean deoxygenation, and particularly hypoxic events, may alter the distribution, aerobic scope, and survival of organisms (Reid et al., 2019). As climate change is projected to continue over this century and beyond, it is expected that the above-mentioned stressors will be intensified, further altering the structure, and functioning of marine ecosystems (Benedetti et al., 2021). Understanding and predicting the effects of climate change is one of the most pressing challenges in marine science, since this knowledge has an impact on fisheries, aquaculture, conservation, and applied ecology. Under this scenario, this Research Topic was conceived for updating and increasing the knowledge of ocean water rise on the biology and physiology of aquatic species, resulting in a Research Topic of four works on crustaceans, fish, and phytoplankton.Versión del edito